Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 4671317..4671878 Replicon chromosome
Accession NZ_CP011112
Organism Luteipulveratus mongoliensis strain MN07-A0370

Toxin (Protein)


Gene name mazF Uniprot ID A0A0K1JML0
Locus tag VV02_RS22180 Protein ID WP_052595168.1
Coordinates 4671528..4671878 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A0K1JMZ4
Locus tag VV02_RS22175 Protein ID WP_052595166.1
Coordinates 4671317..4671544 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VV02_RS22155 4666642..4667592 - 951 WP_052595161.1 hydroxymethylglutaryl-CoA lyase -
VV02_RS22160 4667717..4669360 + 1644 WP_052595163.1 DEAD/DEAH box helicase -
VV02_RS22165 4669365..4670822 - 1458 WP_052597413.1 MFS transporter -
VV02_RS22170 4670933..4671247 + 315 WP_052597415.1 ArsR family transcriptional regulator -
VV02_RS22175 4671317..4671544 + 228 WP_052595166.1 ribbon-helix-helix domain-containing protein Antitoxin
VV02_RS22180 4671528..4671878 + 351 WP_052595168.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
VV02_RS22185 4671890..4672534 - 645 WP_052595170.1 response regulator transcription factor -
VV02_RS22190 4672566..4673918 - 1353 WP_169787736.1 sensor histidine kinase -
VV02_RS22195 4673999..4674562 - 564 WP_052595175.1 dihydrofolate reductase family protein -
VV02_RS22200 4674559..4674921 - 363 WP_052595178.1 hypothetical protein -
VV02_RS22205 4674983..4675405 - 423 WP_083450355.1 response regulator transcription factor -
VV02_RS22210 4675516..4675986 - 471 WP_052595182.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12452.28 Da        Isoelectric Point: 10.6531

>T53396 WP_052595168.1 NZ_CP011112:4671528-4671878 [Luteipulveratus mongoliensis]
MILRGEVWLADLDPHRGSDAAKQRPVVIVSNDGANAAASRLETGVVTVVPVTSNVARVLPFQVALTPPDSGLRRESKAQA
EQVRSIDVGRLGSRLGRLSPTALWQVDEALRLHLAL

Download         Length: 351 bp

>T53396 NZ_CP011112:4671528-4671878 [Luteipulveratus mongoliensis]
ATGATCCTGCGCGGTGAGGTCTGGCTCGCGGATCTGGATCCACACCGAGGATCTGACGCAGCCAAGCAGCGCCCCGTCGT
GATCGTGAGCAACGACGGCGCGAATGCCGCCGCGAGCCGTCTTGAGACCGGGGTTGTCACGGTCGTACCAGTGACCTCCA
ACGTGGCCCGCGTCCTGCCCTTTCAGGTCGCGCTGACACCGCCGGACTCGGGTCTACGGCGCGAGTCCAAGGCGCAGGCC
GAGCAGGTTCGCTCGATCGACGTCGGGCGACTCGGCAGTCGGCTCGGACGGCTCAGCCCCACAGCGCTGTGGCAGGTGGA
CGAGGCGTTGCGCCTCCACCTCGCGCTCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8418.27 Da        Isoelectric Point: 4.1421

>AT53396 WP_052595166.1 NZ_CP011112:4671317-4671544 [Luteipulveratus mongoliensis]
MKLSVSLPDPDVEFLDAFARERAETRSAALLQAVRLLRARELEGAYEEAFGEWHDSGERELWAAATEDGLDDPAR

Download         Length: 228 bp

>AT53396 NZ_CP011112:4671317-4671544 [Luteipulveratus mongoliensis]
ATGAAGCTGAGCGTGAGCCTCCCGGACCCTGACGTCGAGTTCCTCGACGCGTTCGCGCGAGAACGCGCTGAGACTCGCTC
TGCCGCGCTACTCCAGGCCGTGCGCCTCCTGCGCGCCCGCGAGCTCGAGGGGGCGTACGAAGAGGCGTTCGGCGAGTGGC
ACGACTCGGGTGAGCGCGAGCTGTGGGCCGCAGCGACGGAGGACGGCCTGGATGATCCTGCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K1JML0

Antitoxin

Source ID Structure
AlphaFold DB A0A0K1JMZ4

References