53390

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 5140440..5140953 Replicon chromosome
Accession NZ_CP011110
Organism Pseudomonas chlororaphis strain PCL1606

Toxin (Protein)


Gene name relE Uniprot ID A0A0C5DT10
Locus tag PCL1606_RS23000 Protein ID WP_044461640.1
Coordinates 5140669..5140953 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0C5DY45
Locus tag PCL1606_RS22995 Protein ID WP_044461641.1
Coordinates 5140440..5140679 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PCL1606_RS22965 5135879..5136412 + 534 WP_045885187.1 hypothetical protein -
PCL1606_RS22970 5136532..5136936 + 405 WP_044461646.1 low affinity iron permease family protein -
PCL1606_RS22975 5137008..5137532 - 525 WP_044461645.1 DUF4142 domain-containing protein -
PCL1606_RS22980 5137670..5139010 - 1341 WP_045885189.1 sensor domain-containing diguanylate cyclase -
PCL1606_RS22985 5139119..5139760 - 642 WP_044461643.1 LysE family translocator -
PCL1606_RS22990 5139888..5140304 - 417 WP_044461642.1 fosfomycin resistance glutathione transferase -
PCL1606_RS22995 5140440..5140679 + 240 WP_044461641.1 CopG family ribbon-helix-helix protein Antitoxin
PCL1606_RS23000 5140669..5140953 + 285 WP_044461640.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PCL1606_RS23005 5141085..5142233 - 1149 WP_045885192.1 L-threonine dehydrogenase -
PCL1606_RS23010 5142391..5143410 + 1020 WP_045885194.1 DUF4917 family protein -
PCL1606_RS23015 5143732..5144274 - 543 WP_044461637.1 XRE family transcriptional regulator -
PCL1606_RS23020 5144435..5145217 + 783 WP_045885196.1 aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-89)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-41)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10796.42 Da        Isoelectric Point: 10.6946

>T53390 WP_044461640.1 NZ_CP011110:5140669-5140953 [Pseudomonas chlororaphis]
MHVEWLRTALKNLDDEAAYIAQDSPQAAAEFVTAILSSIQHLAHFPASGREGRLPGTREWVVPNRPYLIPYRVRQGRLQI
LRIFHTRRLPPAGW

Download         Length: 285 bp

>T53390 NZ_CP011110:5140669-5140953 [Pseudomonas chlororaphis]
ATGCACGTTGAGTGGCTGCGTACCGCCCTCAAGAACCTCGATGACGAAGCCGCCTACATTGCACAAGACAGTCCTCAGGC
CGCCGCGGAATTCGTCACAGCCATCCTGAGCAGTATTCAACACCTGGCCCATTTTCCTGCCAGTGGGCGCGAAGGTCGCC
TGCCCGGTACCCGAGAGTGGGTGGTCCCCAATCGTCCTTACCTGATCCCCTACCGCGTACGTCAGGGACGCCTGCAGATA
CTGCGGATTTTCCATACCCGGCGCTTGCCGCCTGCCGGATGGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8677.76 Da        Isoelectric Point: 4.4217

>AT53390 WP_044461641.1 NZ_CP011110:5140440-5140679 [Pseudomonas chlororaphis]
MSVMSLRLPDDVADTLAHLAKATGRSKSFLAVDALREYLAREAWQIDEIQKALTEAEAGDFVSAEELDGVLNKWTGNAR

Download         Length: 240 bp

>AT53390 NZ_CP011110:5140440-5140679 [Pseudomonas chlororaphis]
ATGTCCGTCATGTCCTTGCGCCTGCCCGATGATGTTGCCGATACCCTGGCTCACTTGGCCAAGGCGACAGGCCGCAGCAA
GTCATTCCTCGCTGTGGATGCCCTGAGAGAATATCTGGCCCGTGAAGCCTGGCAAATCGACGAGATTCAGAAAGCCCTGA
CCGAAGCAGAAGCAGGCGACTTCGTCAGCGCCGAAGAGCTGGATGGCGTACTCAACAAATGGACTGGCAATGCACGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C5DT10

Antitoxin

Source ID Structure
AlphaFold DB A0A0C5DY45

References