Detailed information of TA system TA053389

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 5116270..5116892
• Replicon: chromosome
• Accession: NZ_CP011110
• Organism: Pseudomonas chlororaphis strain PCL1606

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A0D5Y4A2
• Locus tag: PCL1606_RS22865
• Protein ID: WP_045885147.1
• Coordinates: 5116270..5116452 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: PCL1606_RS22870
• Protein ID: WP_045886931.1
• Coordinates: 5116485..5116892 (+)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PCL1606_RS22850	5112839..5114158	+	1320	WP_148558681.1	MFS transporter	-
PCL1606_RS22855	5114183..5114935	+	753	WP_045885144.1	Asp/Glu racemase	-
PCL1606_RS22860	5114957..5115874	+	918	WP_171820073.1	LysR family transcriptional regulator	-
PCL1606_RS22865	5116270..5116452	+	183	WP_045885147.1	type II toxin-antitoxin system HicA family toxin	Toxin
PCL1606_RS22870	5116485..5116892	+	408	WP_045886931.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
PCL1606_RS22875	5117095..5117562	+	468	WP_045885150.1	GAF domain-containing protein	-
PCL1606_RS22880	5117692..5118606	+	915	WP_045885153.1	SGNH/GDSL hydrolase family protein	-
PCL1606_RS22885	5118636..5120414	-	1779	WP_045885156.1	sensor domain-containing phosphodiesterase	-
PCL1606_RS22890	5120652..5121542	-	891	WP_045886933.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-57)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6881.12 Da
• Isoelectric Point: 11.2176

>T53389 WP_045885147.1 NZ_CP011110:5116270-5116452 [Pseudomonas chlororaphis]
VDSRYLISQIVADGWYLVRVRGSHHHFRHPSKPGLVTVPHPQKDLLRKTAISILKQALLM

Nucleotide

• Length: 183 bp

>T53389 NZ_CP011110:5116270-5116452 [Pseudomonas chlororaphis]
GTGGACAGTCGGTATTTGATCAGCCAAATCGTCGCAGACGGTTGGTATCTGGTCAGGGTCAGAGGCAGTCACCACCATTT
CCGCCACCCCAGCAAACCGGGGCTGGTGACTGTCCCGCATCCGCAAAAGGACCTGCTGAGAAAAACCGCCATCAGCATTC
TGAAACAGGCGCTGCTCATGTGA

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 14696.68 Da
• Isoelectric Point: 4.4893

>AT53389 WP_045886931.1 NZ_CP011110:5116485-5116892 [Pseudomonas chlororaphis]
MLYPIAISMGDDEHAWGVEVPDIPGCFSAGDDLDDALAMAREAIEGHFELLAEEGAAIPHANKLTLHAANPQYAGCTWAL
VDIDITRYLGKAQKLNITLPGYLLNRIDEYVLHHPEAKSRSGFLASAALKVLQQE

Nucleotide

• Length: 408 bp

>AT53389 NZ_CP011110:5116485-5116892 [Pseudomonas chlororaphis]
ATGCTTTACCCAATTGCCATTTCAATGGGCGATGACGAACACGCCTGGGGCGTGGAAGTCCCGGATATTCCTGGCTGCTT
CTCGGCCGGCGACGACCTCGACGATGCCCTGGCCATGGCCCGCGAAGCCATCGAAGGGCACTTCGAGCTTCTCGCCGAAG
AAGGTGCCGCCATCCCGCACGCCAACAAGCTCACCTTGCACGCAGCCAACCCGCAGTACGCAGGCTGCACCTGGGCGCTG
GTCGACATCGACATCACCCGCTACCTGGGCAAGGCGCAAAAGCTCAACATCACCCTGCCCGGCTACCTGCTGAACCGTAT
CGACGAATACGTACTGCATCACCCGGAAGCGAAGAGCCGCTCGGGTTTTCTCGCTTCGGCTGCCTTGAAGGTATTGCAGC
AAGAATGA

Structures

Toxin

• AlphaFold DB: A0A0D5Y4A2