Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4306994..4307613 Replicon chromosome
Accession NZ_CP011110
Organism Pseudomonas chlororaphis strain PCL1606

Toxin (Protein)


Gene name hicA Uniprot ID A0A0D5Y303
Locus tag PCL1606_RS19040 Protein ID WP_045886891.1
Coordinates 4306994..4307176 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0D5Y203
Locus tag PCL1606_RS19045 Protein ID WP_045884264.1
Coordinates 4307212..4307613 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PCL1606_RS30410 4302498..4304375 - 1878 WP_080925991.1 caspase family protein -
PCL1606_RS30985 4304372..4305010 - 639 WP_148558671.1 hypothetical protein -
PCL1606_RS19030 4305404..4305910 - 507 WP_045884260.1 hypothetical protein -
PCL1606_RS19035 4306554..4306835 + 282 WP_045884262.1 hypothetical protein -
PCL1606_RS19040 4306994..4307176 + 183 WP_045886891.1 type II toxin-antitoxin system HicA family toxin Toxin
PCL1606_RS19045 4307212..4307613 + 402 WP_045884264.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PCL1606_RS19050 4308217..4308975 - 759 WP_045884267.1 hypothetical protein -
PCL1606_RS19055 4309213..4309836 + 624 WP_045884270.1 HAD family phosphatase -
PCL1606_RS19060 4309861..4310874 - 1014 WP_045884271.1 AraC family transcriptional regulator -
PCL1606_RS19065 4311046..4311897 + 852 WP_045884272.1 3-hydroxybutyryl-CoA dehydrogenase -
PCL1606_RS19070 4311890..4312486 + 597 WP_044462352.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6785.01 Da        Isoelectric Point: 11.3631

>T53388 WP_045886891.1 NZ_CP011110:4306994-4307176 [Pseudomonas chlororaphis]
VQSRQLIKELEAAGWVLDRVTGSHHLFKHPYRPKTVPVPHPKKDLPRGTVRAIQKLAGLI

Download         Length: 183 bp

>T53388 NZ_CP011110:4306994-4307176 [Pseudomonas chlororaphis]
GTGCAAAGCAGACAGTTGATCAAGGAGCTTGAAGCCGCAGGCTGGGTGCTGGATCGCGTTACCGGCAGCCATCATCTGTT
CAAGCATCCCTACCGGCCCAAGACCGTTCCGGTGCCTCACCCGAAGAAGGATCTGCCACGGGGGACGGTCAGGGCCATCC
AGAAACTGGCCGGGCTGATATAG

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14587.61 Da        Isoelectric Point: 4.9136

>AT53388 WP_045884264.1 NZ_CP011110:4307212-4307613 [Pseudomonas chlororaphis]
VQYPICIEWGNEHTATGIQIPDIPGAITAGDSFEAAYGAAIEIAHLMLEELAREGHAIPLPTSIGTHRANPDFEGMGWGM
LDIDITPYLGKTEKVNVTLPGYVIQRIDRFVREHNIKSRSSFLADAAMEKLGR

Download         Length: 402 bp

>AT53388 NZ_CP011110:4307212-4307613 [Pseudomonas chlororaphis]
GTGCAATATCCCATCTGCATCGAGTGGGGCAACGAACACACGGCCACCGGCATCCAGATTCCCGACATTCCCGGAGCGAT
CACCGCCGGCGACAGCTTCGAGGCCGCCTATGGCGCCGCCATCGAGATCGCCCACCTCATGCTCGAAGAGCTGGCCCGCG
AGGGGCATGCCATTCCCCTGCCCACCTCCATCGGCACGCACCGCGCCAACCCCGATTTCGAGGGCATGGGCTGGGGCATG
CTGGATATCGACATCACGCCTTACCTGGGCAAGACCGAGAAGGTCAACGTGACCCTGCCGGGCTACGTGATCCAGCGGAT
CGACCGCTTTGTCCGGGAGCACAACATCAAGAGCCGGTCGTCGTTCCTGGCGGATGCGGCGATGGAAAAGCTGGGGCGTT
AA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D5Y303

Antitoxin

Source ID Structure
AlphaFold DB A0A0D5Y203

References