Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 4289396..4289982 Replicon chromosome
Accession NZ_CP011110
Organism Pseudomonas chlororaphis strain PCL1606

Toxin (Protein)


Gene name PumA Uniprot ID A0A0C5E2U7
Locus tag PCL1606_RS18970 Protein ID WP_044462369.1
Coordinates 4289396..4289689 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A0C5E757
Locus tag PCL1606_RS18975 Protein ID WP_044462368.1
Coordinates 4289692..4289982 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PCL1606_RS18955 4285061..4286305 - 1245 WP_044462372.1 M20/M25/M40 family metallo-hydrolase -
PCL1606_RS18960 4286398..4287522 - 1125 WP_045884236.1 diguanylate cyclase -
PCL1606_RS18965 4287766..4289160 + 1395 WP_045884239.1 VOC family protein -
PCL1606_RS18970 4289396..4289689 + 294 WP_044462369.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PCL1606_RS18975 4289692..4289982 + 291 WP_044462368.1 putative addiction module antidote protein Antitoxin
PCL1606_RS18980 4290365..4290952 - 588 WP_045884242.1 hypothetical protein -
PCL1606_RS18985 4291072..4292454 - 1383 WP_045884245.1 efflux transporter outer membrane subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Uncharacterized protein HI1420

(8-91)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10756.43 Da        Isoelectric Point: 9.9430

>T53387 WP_044462369.1 NZ_CP011110:4289396-4289689 [Pseudomonas chlororaphis]
MDYEILQTTAFARWHTTLRDLRARIAIARRLERAAAGNLGDVKNLGGGLMEMRVNTGAGYRLYFTLRGCTLIVLLLGGDK
STQPADIDQARALAKEY

Download         Length: 294 bp

>T53387 NZ_CP011110:4289396-4289689 [Pseudomonas chlororaphis]
ATGGATTACGAGATCCTGCAAACCACCGCCTTTGCCCGGTGGCACACCACGCTACGGGACCTGCGCGCCAGGATCGCCAT
CGCTCGGCGCCTGGAGCGGGCCGCGGCGGGCAACCTGGGCGATGTGAAGAACCTGGGTGGTGGTCTCATGGAAATGCGCG
TGAATACCGGCGCCGGCTACCGCCTCTATTTCACGCTTCGCGGGTGCACCCTCATCGTCCTGTTGCTGGGCGGCGACAAG
TCCACCCAGCCAGCCGATATCGACCAGGCCCGTGCCCTGGCCAAGGAGTATTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10285.85 Da        Isoelectric Point: 8.0389

>AT53387 WP_044462368.1 NZ_CP011110:4289692-4289982 [Pseudomonas chlororaphis]
MSDTLVPFDIAALLDSDQAISEYLSQVLADGDTDELIRALGHVARARGMTQIAKHTGQGRASLYKAFAPGAKPRFDTVVK
VMRALGLQLCTTVPRG

Download         Length: 291 bp

>AT53387 NZ_CP011110:4289692-4289982 [Pseudomonas chlororaphis]
ATGTCCGACACACTGGTTCCCTTCGACATTGCCGCCCTGCTCGACAGCGACCAGGCGATCAGCGAGTACCTGTCCCAGGT
CCTCGCCGACGGCGATACCGACGAGCTGATCCGCGCCCTGGGCCATGTCGCCCGGGCCCGCGGCATGACGCAGATCGCCA
AGCACACCGGCCAGGGCCGGGCCAGCCTCTACAAGGCGTTTGCCCCCGGCGCCAAGCCGCGCTTCGATACGGTGGTCAAG
GTCATGCGCGCCCTTGGCCTGCAGTTGTGCACGACCGTGCCGCGCGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C5E2U7

Antitoxin

Source ID Structure
AlphaFold DB A0A0C5E757

References