53382

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 624836..625476 Replicon chromosome
Accession NZ_CP011110
Organism Pseudomonas chlororaphis strain PCL1606

Toxin (Protein)


Gene name hicA Uniprot ID A0A0D5XSI4
Locus tag PCL1606_RS02875 Protein ID WP_045886686.1
Coordinates 625294..625476 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0D5XTH8
Locus tag PCL1606_RS02870 Protein ID WP_045881020.1
Coordinates 624836..625261 (-) Length 142 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PCL1606_RS02850 622147..622785 - 639 WP_080926027.1 lipopolysaccharide biosynthesis protein -
PCL1606_RS02855 623392..623637 - 246 WP_045881016.1 hypothetical protein -
PCL1606_RS30055 624220..624462 + 243 WP_080925908.1 hypothetical protein -
PCL1606_RS02870 624836..625261 - 426 WP_045881020.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PCL1606_RS02875 625294..625476 - 183 WP_045886686.1 type II toxin-antitoxin system HicA family toxin Toxin
PCL1606_RS02880 625701..626333 + 633 WP_171820025.1 hypothetical protein -
PCL1606_RS02885 626330..627301 - 972 WP_045881022.1 hypothetical protein -
PCL1606_RS02890 627274..627978 - 705 WP_045881023.1 hypothetical protein -
PCL1606_RS02895 627975..628520 - 546 WP_045881024.1 hypothetical protein -
PCL1606_RS02900 628517..629440 - 924 WP_045886688.1 hypothetical protein -
PCL1606_RS02905 629437..630144 - 708 WP_045881025.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 624836..673977 49141


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-58)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6754.79 Da        Isoelectric Point: 10.7304

>T53382 WP_045886686.1 NZ_CP011110:c625476-625294 [Pseudomonas chlororaphis]
MKYSEFRRWLKAQGAEFQSGKGSHFKVTLNGKSTVFPDHGAKEMGEGLRKSIIKQLGLKD

Download         Length: 183 bp

>T53382 NZ_CP011110:c625476-625294 [Pseudomonas chlororaphis]
ATGAAGTACAGCGAGTTTCGGCGATGGTTGAAGGCCCAAGGCGCAGAGTTCCAAAGCGGCAAGGGCAGTCACTTCAAGGT
CACCTTGAATGGCAAGTCAACTGTGTTTCCTGACCACGGAGCCAAGGAAATGGGCGAAGGGTTGAGGAAGTCGATAATCA
AACAGTTGGGCCTCAAGGATTGA

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15513.59 Da        Isoelectric Point: 4.3768

>AT53382 WP_045881020.1 NZ_CP011110:c625261-624836 [Pseudomonas chlororaphis]
MFKYALEIHEEPGTVWLSCEEIPEFHAAGDTVGEALESALDALETALSIYVDERRPIPSGNAEAQAGDVLLRLPALTAAK
VALWNAVLDEGTPKTELARRLGIQRPQVDRLLDFLHDSKIENVERALQELGRRISITVEAA

Download         Length: 426 bp

>AT53382 NZ_CP011110:c625261-624836 [Pseudomonas chlororaphis]
ATGTTCAAGTACGCATTGGAAATTCACGAAGAGCCCGGCACCGTGTGGCTTTCGTGTGAAGAGATTCCAGAGTTTCACGC
TGCCGGCGACACTGTAGGCGAGGCCCTGGAAAGCGCTTTGGATGCGCTCGAAACGGCTCTGTCTATCTATGTTGATGAAC
GCCGCCCGATTCCATCTGGTAACGCTGAGGCTCAGGCAGGGGACGTTCTGCTGCGCCTTCCAGCCCTCACCGCGGCAAAA
GTCGCACTGTGGAACGCGGTATTGGATGAAGGCACCCCCAAGACAGAGCTGGCGCGCCGCCTGGGGATTCAGCGGCCGCA
GGTGGACCGCTTGCTGGACTTCCTGCATGACTCGAAAATCGAGAACGTCGAGCGCGCCCTGCAGGAACTCGGCCGGCGGA
TCTCTATCACCGTCGAGGCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D5XSI4

Antitoxin

Source ID Structure
AlphaFold DB A0A0D5XTH8

References