Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) rlegTA/AbiEii-AbiEi
Location 2807761..2809217 Replicon chromosome
Accession NZ_CP011105
Organism Legionella pneumophila strain L10-023 isolate Ulm

Toxin (Protein)


Gene name rlegT Uniprot ID -
Locus tag ULM_RS12685 Protein ID WP_014842352.1
Coordinates 2807761..2808612 (-) Length 284 a.a.

Antitoxin (Protein)


Gene name rlegA Uniprot ID -
Locus tag ULM_RS12690 Protein ID WP_027265135.1
Coordinates 2808609..2809217 (-) Length 203 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ULM_RS12650 2802952..2803305 - 354 WP_014842347.1 conjugal transfer transcriptional regulator TraJ -
ULM_RS12655 2803720..2804064 + 345 WP_014842348.1 TraK family protein -
ULM_RS12660 2804064..2804789 + 726 WP_014842349.1 conjugal transfer protein TraL -
ULM_RS12665 2804789..2805229 + 441 WP_042754801.1 conjugal transfer protein TraM -
ULM_RS12670 2805394..2806428 + 1035 WP_027265137.1 putative DNA binding domain-containing protein -
ULM_RS17990 2807172..2807252 - 81 WP_152027460.1 transposase -
ULM_RS17590 2807261..2807680 + 420 Protein_2499 DUF2779 domain-containing protein -
ULM_RS12685 2807761..2808612 - 852 WP_014842352.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
ULM_RS12690 2808609..2809217 - 609 WP_027265135.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
ULM_RS12695 2809460..2809723 + 264 WP_014842354.1 hypothetical protein -
ULM_RS12700 2809723..2810484 + 762 WP_042754800.1 DUF3800 domain-containing protein -
ULM_RS12705 2810892..2812040 + 1149 WP_014842362.1 outer membrane beta-barrel protein -
ULM_RS12710 2812070..2813188 + 1119 WP_014842363.1 DUF3494 domain-containing protein -
ULM_RS17995 2813492..2813650 + 159 WP_154080660.1 hypothetical protein -
ULM_RS12715 2813698..2814039 + 342 WP_027265134.1 IS630 transposase-related protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(35-262)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(9-56)


Sequences

Toxin        


Download         Length: 284 a.a.        Molecular weight: 31702.65 Da        Isoelectric Point: 6.2785

>T53376 WP_014842352.1 NZ_CP011105:c2808612-2807761 [Legionella pneumophila]
MIKNIGESVRSRLKNIAVKEGSDFNAVLTRYGLERLLYRIGESEYSNQFLLKGALLFNLWYDMPHRPTKDIDLLGFGDND
LAYIKQTFSKICSIFADDGISFLSESVTVDTIKKDGGYTGARVELFGELAKAKIKIQIDIGYGDAVTPGPIDAHYPVLLS
DLPAPKIRTYPIYTVIAEKLHAIALLGMANGRLKDYLDLYVLLGNEQIDNQILAKAIQATFNRRGMDLPEALPIGLTDEF
ANDPSRESMWKAFLRKNELEQKPLTEVIAVIRNLIQVPYSLAK

Download         Length: 852 bp

>T53376 NZ_CP011105:c2808612-2807761 [Legionella pneumophila]
ATGATCAAAAATATTGGTGAGTCCGTACGCTCACGTTTGAAGAATATAGCTGTTAAAGAAGGTTCTGATTTTAATGCGGT
ATTGACTCGTTATGGTCTAGAGCGTTTGTTGTATCGAATTGGAGAATCAGAATATTCTAACCAGTTTTTGTTGAAAGGTG
CCTTACTGTTTAACCTATGGTACGACATGCCCCATCGCCCAACTAAAGATATTGATTTATTGGGATTTGGTGATAACGAT
CTGGCGTATATTAAGCAAACGTTCAGTAAAATTTGCAGCATCTTTGCAGATGATGGAATAAGTTTTCTGTCTGAATCAGT
GACGGTTGACACTATCAAAAAAGATGGAGGTTATACTGGAGCAAGAGTTGAGTTATTTGGGGAATTGGCGAAAGCAAAGA
TTAAAATACAAATTGATATAGGTTATGGTGATGCAGTTACGCCTGGGCCAATAGATGCCCATTATCCCGTACTTCTTAGT
GATCTTCCTGCCCCTAAAATCCGTACTTATCCAATTTATACGGTAATTGCAGAAAAGCTGCACGCAATTGCATTATTGGG
CATGGCGAATGGTCGATTAAAAGACTACTTGGATCTTTATGTATTATTAGGTAATGAACAGATAGATAATCAAATCTTGG
CTAAAGCTATACAAGCCACATTTAATCGTCGAGGTATGGATCTTCCTGAAGCACTGCCTATTGGCCTGACCGATGAGTTT
GCTAACGACCCAAGCAGGGAGTCAATGTGGAAAGCCTTTTTGAGAAAAAATGAACTAGAGCAGAAACCATTAACTGAAGT
CATTGCTGTGATCAGAAATTTGATTCAAGTGCCATATTCTTTGGCAAAGTAA

Antitoxin


Download         Length: 203 a.a.        Molecular weight: 22977.01 Da        Isoelectric Point: 9.6557

>AT53376 WP_027265135.1 NZ_CP011105:c2809217-2808609 [Legionella pneumophila]
MKTEVNNKQKVLQMASKTGVIRMSDLTKKGITRATISRLVSENKLEKLAPGLYCLPETEFSEKESLVIIASRVPQAVFCL
LTALQIHDLTTQLPRKVWIAMPKGSHAPKMDYPPLKMVQYSDEAFSEGIEIIESDNIKLRVYNRAKTIADCFKHRNKIGL
DVAIEALKEAYTKNKVIVDELWHYAKICRVANVMRPYIEAIQ

Download         Length: 609 bp

>AT53376 NZ_CP011105:c2809217-2808609 [Legionella pneumophila]
ATGAAGACAGAGGTCAACAATAAACAAAAAGTTCTCCAGATGGCTAGTAAAACGGGCGTTATTAGAATGTCCGATCTGAC
CAAGAAGGGGATCACTAGAGCGACCATTTCAAGGCTTGTTAGCGAAAACAAACTTGAAAAACTCGCTCCTGGACTCTATT
GCCTGCCCGAGACTGAGTTTTCAGAAAAGGAAAGCCTGGTTATTATAGCAAGTCGAGTACCTCAAGCAGTGTTTTGCCTG
CTAACTGCTTTGCAGATTCATGATCTAACAACACAGCTACCTCGAAAAGTATGGATAGCTATGCCAAAAGGGAGTCATGC
GCCAAAAATGGATTATCCTCCGCTAAAAATGGTGCAATATTCAGATGAAGCCTTTAGTGAAGGAATTGAAATTATAGAAT
CAGATAATATTAAACTAAGGGTGTATAACCGTGCCAAGACAATTGCAGATTGTTTCAAACATCGCAATAAAATTGGACTT
GATGTGGCCATTGAAGCGCTCAAAGAGGCTTATACAAAAAATAAAGTCATAGTTGATGAACTATGGCATTATGCGAAAAT
TTGTCGCGTTGCAAACGTAATGCGTCCTTATATTGAGGCAATTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References