Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) rlegTA/AbiEii-AbiEi
Location 2757219..2758675 Replicon chromosome
Accession NZ_CP011105
Organism Legionella pneumophila strain L10-023 isolate Ulm

Toxin (Protein)


Gene name rlegT Uniprot ID -
Locus tag ULM_RS12420 Protein ID WP_062725383.1
Coordinates 2757219..2758070 (-) Length 284 a.a.

Antitoxin (Protein)


Gene name rlegA Uniprot ID -
Locus tag ULM_RS12425 Protein ID WP_062725381.1
Coordinates 2758067..2758675 (-) Length 203 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ULM_RS17985 2754517..2754678 + 162 WP_154699017.1 hypothetical protein -
ULM_RS12410 2755026..2756264 - 1239 WP_062724776.1 IS256 family transposase -
ULM_RS12415 2756382..2757086 + 705 WP_062740838.1 GGDEF domain-containing protein -
ULM_RS12420 2757219..2758070 - 852 WP_062725383.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
ULM_RS12425 2758067..2758675 - 609 WP_062725381.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
ULM_RS12430 2759115..2759990 + 876 WP_014842379.1 hypothetical protein -
ULM_RS12435 2760122..2761626 - 1505 Protein_2452 cytidine deaminase -
ULM_RS12445 2762024..2762554 + 531 WP_027220509.1 hypothetical protein -
ULM_RS12450 2762771..2763136 - 366 WP_014842383.1 TraK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(35-259)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(9-56)


Sequences

Toxin        


Download         Length: 284 a.a.        Molecular weight: 31902.98 Da        Isoelectric Point: 7.9767

>T53375 WP_062725383.1 NZ_CP011105:c2758070-2757219 [Legionella pneumophila]
MTKNIGESLRSRLKNIAVKEGSDFNAVLTRYGLERMLYRIGESEYSNQFLLKGALLFNLWYDMPHRPTKDIDLLGFGDND
MAYIKQTFSKICSISADDGISFLSESVTVNTIKKDGGYTGARVELFGELAKAKIKIQIDIGYGDAVTPRPIDAHYPVLLS
DLPAPKIRTYPIYTVIAEKLHAIAFLGMANSRLKDYLDLYVLLNNEQLDNQILAKAIQATFNRRGMTLPEALPIGLTDEF
ANDPTRESMWKAFLRKNELEQKSLTEVIVVIRNLILMPFALAK

Download         Length: 852 bp

>T53375 NZ_CP011105:c2758070-2757219 [Legionella pneumophila]
ATGACAAAAAATATTGGTGAATCCTTACGCTCACGTTTGAAAAATATAGCCGTTAAAGAAGGTTCTGACTTTAATGCAGT
CTTAACCCGTTATGGTCTAGAGCGCATGTTATATAGAATTGGGGAATCAGAATATTCTAATCAGTTTTTGTTAAAAGGTG
CTTTATTGTTTAACCTATGGTACGACATGCCCCATCGTCCAACTAAAGATATTGATTTATTGGGGTTTGGTGATAATGAT
ATGGCGTATATTAAACAAACGTTCAGTAAAATTTGTAGCATCTCAGCAGATGATGGAATAAGTTTTCTGTCTGAATCAGT
GACGGTAAACACTATAAAAAAAGATGGTGGTTACACGGGAGCAAGAGTTGAGTTATTTGGGGAATTGGCGAAGGCAAAAA
TTAAAATACAAATTGATATTGGTTATGGTGATGCAGTTACTCCCCGGCCAATAGACGCTCATTATCCTGTACTTCTTAGT
GATCTTCCTGCCCCTAAAATTCGCACTTATCCAATTTATACGGTAATTGCAGAAAAGCTGCACGCAATTGCATTCTTGGG
CATGGCGAATAGCCGATTAAAAGACTATTTGGATCTTTATGTATTATTAAATAACGAGCAGTTGGATAATCAAATCTTGG
CTAAAGCCATACAGGCTACGTTTAATCGCCGAGGGATGACTCTCCCTGAAGCGCTGCCTATTGGCCTGACTGATGAATTC
GCCAATGACCCAACCAGAGAATCAATGTGGAAAGCATTTTTGAGAAAGAATGAACTAGAGCAGAAGTCATTAACAGAAGT
TATTGTTGTGATCAGAAATTTGATCCTAATGCCATTTGCTTTGGCAAAGTAA

Antitoxin


Download         Length: 203 a.a.        Molecular weight: 22947.90 Da        Isoelectric Point: 9.7451

>AT53375 WP_062725381.1 NZ_CP011105:c2758675-2758067 [Legionella pneumophila]
MKTEATYKQKVLQMASKTGIVRMSDLTKRGITRATISRLVSENKLEKLASGLYCLPETEFSEKESLIIIASRVPKAVFCL
LTALQIHELTTQLPRKVWIAMPKGSHTPKMDYPPVKMVQYSDEAFSEGIEIIDSDNIKLRVYNLAKTIADSFKHRNKIGL
DVAIEALKEAYSKNKVTVDELWHYAKICRVANVMRPYIEAIQ

Download         Length: 609 bp

>AT53375 NZ_CP011105:c2758675-2758067 [Legionella pneumophila]
ATGAAGACTGAAGCTACCTATAAACAAAAAGTACTCCAGATGGCTAGTAAAACGGGCATTGTTAGAATGTCCGATCTAAC
CAAAAGAGGGATCACTAGAGCGACCATATCAAGGCTTGTTAGCGAAAACAAACTTGAAAAACTCGCTTCTGGGCTCTATT
GCTTGCCGGAGACTGAGTTTTCAGAAAAAGAAAGCCTGATTATTATAGCAAGCCGAGTACCTAAAGCAGTGTTTTGCCTA
CTAACTGCTTTGCAGATACATGAGCTAACAACACAGCTACCACGAAAAGTATGGATAGCTATGCCAAAAGGCAGTCATAC
GCCAAAAATGGATTATCCACCGGTAAAAATGGTGCAATATTCAGATGAAGCCTTTAGCGAAGGAATTGAAATTATAGACT
CAGATAATATTAAACTAAGGGTGTATAATCTGGCCAAGACAATTGCAGATTCTTTCAAACACCGCAATAAAATTGGCCTT
GACGTGGCCATTGAAGCGCTCAAAGAAGCTTATTCAAAAAATAAAGTAACAGTTGATGAACTATGGCATTATGCGAAAAT
TTGTCGCGTTGCAAACGTAATGCGTCCTTATATTGAGGCAATTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References