Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 67802..69339 Replicon chromosome
Accession NZ_CP011105
Organism Legionella pneumophila strain L10-023 isolate Ulm

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag ULM_RS00325 Protein ID WP_042755327.1
Coordinates 67802..69106 (-) Length 435 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag ULM_RS00330 Protein ID WP_014840730.1
Coordinates 69100..69339 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ULM_RS00300 63348..64595 + 1248 WP_061363827.1 hypothetical protein -
ULM_RS17910 64715..64870 + 156 WP_154694746.1 hypothetical protein -
ULM_RS00305 64892..65296 - 405 WP_011945253.1 MerR family transcriptional regulator -
ULM_RS00310 65366..66118 + 753 WP_042755325.1 glutaredoxin family protein -
ULM_RS00315 66308..67411 + 1104 WP_042755326.1 hypothetical protein -
ULM_RS00320 67453..67771 + 319 Protein_64 integrase -
ULM_RS00325 67802..69106 - 1305 WP_042755327.1 type II toxin-antitoxin system HipA family toxin Toxin
ULM_RS00330 69100..69339 - 240 WP_014840730.1 helix-turn-helix domain-containing protein Antitoxin
ULM_RS00335 69433..69663 + 231 Protein_67 hypothetical protein -
ULM_RS00340 69991..70356 + 366 WP_042755329.1 hypothetical protein -
ULM_RS00345 70357..70578 + 222 WP_042755330.1 hypothetical protein -
ULM_RS00350 70844..71938 + 1095 WP_062896145.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 435 a.a.        Molecular weight: 49644.97 Da        Isoelectric Point: 7.7618

>T53373 WP_042755327.1 NZ_CP011105:c69106-67802 [Legionella pneumophila]
MVMRKLYILMNNELVGELTQDNAGGLSFSYVADWISKPHSRPVSLSLPLINQRISGEVVYNFFDNLLPDNPQIRARIQAR
FQAKSSRPFDLLALIGSDCVGAIQIVERIPQTQRLSIESHVVSEAEIARTLRSYQTSPLGMDKEDDEFRISIAGAQEKTA
FLYYQNEWHKPFGPTPTTHIFKLPIGYLPHQGIDLSESCENEHLCLLLASKFGLEVAKSKILQFEDEKVLVVERFDRKWS
RDNRYILRLPQEDLCQALGYSPNLKYQSDGGPGIKEIMQLLNGSQQPQKDRDEFFRAQVVYWCLGAIDAHAKNFSISIQP
QGGYQLTPLYDIISAYPIVEQKQLSFKKLKMAMALYGKNSHYKIDGIQKRHFIETAKYVQYSKIKAAQIFEQVIDRIDSA
IDEVSTQLPNHFPEKIADPIFKGMRAFKERMIST

Download         Length: 1305 bp

>T53373 NZ_CP011105:c69106-67802 [Legionella pneumophila]
ATGGTAATGCGTAAATTATACATATTGATGAACAATGAGCTCGTGGGGGAGCTTACCCAGGATAATGCAGGTGGTTTGAG
TTTTTCCTACGTTGCTGACTGGATTTCCAAGCCGCATTCACGCCCAGTTTCTTTATCGTTACCGTTAATAAATCAAAGGA
TTTCAGGAGAAGTTGTTTATAACTTTTTTGATAATTTACTTCCCGATAATCCACAGATAAGAGCGAGAATTCAAGCTCGT
TTTCAGGCAAAATCATCGCGACCGTTTGATTTATTGGCGTTAATTGGCAGTGATTGTGTTGGTGCAATACAAATTGTTGA
ACGTATTCCTCAGACACAGCGTCTAAGCATTGAAAGTCACGTTGTCAGTGAGGCCGAGATAGCTCGTACTTTACGTTCTT
ACCAAACCTCACCACTGGGAATGGATAAAGAGGATGATGAGTTTAGAATCTCAATAGCCGGTGCTCAGGAAAAAACGGCT
TTTCTATATTACCAAAATGAATGGCATAAACCATTTGGACCTACACCAACAACTCACATATTCAAATTACCTATTGGATA
TTTACCACATCAAGGAATTGATTTAAGTGAGAGTTGTGAAAATGAGCATCTCTGTTTACTACTAGCCAGCAAATTTGGTT
TAGAGGTTGCAAAATCAAAAATCTTACAATTCGAAGATGAAAAGGTGCTGGTTGTCGAAAGATTTGATAGAAAATGGAGT
CGAGATAACCGTTATATACTCAGGTTACCGCAAGAAGACCTATGCCAAGCGTTGGGTTATTCACCAAATTTAAAATATCA
GTCAGATGGTGGCCCCGGTATTAAAGAAATTATGCAGCTACTTAATGGCTCACAGCAGCCTCAAAAAGATAGAGATGAAT
TTTTCAGAGCACAGGTTGTTTACTGGTGCCTTGGTGCTATTGATGCGCATGCCAAAAATTTCAGTATAAGTATACAACCA
CAAGGCGGTTACCAGCTCACCCCCTTATACGACATCATTTCAGCCTATCCTATCGTGGAACAAAAACAGCTATCCTTTAA
GAAATTGAAAATGGCAATGGCTTTATATGGTAAAAATAGTCATTACAAGATTGACGGTATTCAAAAAAGACACTTTATTG
AAACAGCAAAATACGTTCAATATTCTAAAATTAAAGCAGCTCAGATTTTTGAACAAGTGATTGACCGTATTGATTCTGCT
ATCGATGAGGTCTCAACACAATTACCAAACCACTTCCCAGAAAAGATTGCAGATCCAATCTTCAAAGGGATGAGAGCTTT
TAAGGAGCGAATGATATCCACATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9096.40 Da        Isoelectric Point: 5.0774

>AT53373 WP_014840730.1 NZ_CP011105:c69339-69100 [Legionella pneumophila]
MIISSAKDLALYLNDKRKQLKMSQSEVADLVGLKQDTISKFENSPDNSRIDTLFRILSALNLNMSLVEKDQKTHEEIEW

Download         Length: 240 bp

>AT53373 NZ_CP011105:c69339-69100 [Legionella pneumophila]
ATGATCATTAGCTCAGCAAAAGATTTAGCATTATATTTAAATGACAAGCGCAAACAACTCAAAATGAGTCAATCTGAAGT
TGCCGATTTAGTCGGCTTAAAACAGGATACCATATCAAAGTTTGAAAATAGCCCTGATAATAGTCGAATTGATACCTTAT
TTAGAATATTGTCCGCCCTAAATTTAAATATGAGCCTTGTTGAAAAAGATCAAAAAACTCATGAAGAGATAGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References