Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE(toxin)
Location 4876042..4876604 Replicon chromosome
Accession NZ_CP011104
Organism Photorhabdus thracensis strain DSM 15199

Toxin (Protein)


Gene name parE Uniprot ID A0A0F7LUE3
Locus tag VY86_RS21290 Protein ID WP_046976470.1
Coordinates 4876326..4876604 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID T0P8Z0
Locus tag VY86_RS21285 Protein ID WP_021324083.1
Coordinates 4876042..4876326 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VY86_RS21250 4871146..4871565 + 420 WP_046976466.1 flagellar motor switch protein FliN -
VY86_RS21255 4871567..4872019 + 453 WP_046976467.1 flagellar biosynthetic protein FliO -
VY86_RS21260 4872069..4872785 + 717 WP_158020045.1 flagellar type III secretion system pore protein FliP -
VY86_RS21265 4872806..4873075 + 270 WP_021324077.1 flagellar biosynthesis protein FliQ -
VY86_RS21270 4873078..4873860 + 783 WP_046976468.1 flagellar type III secretion system protein FliR -
VY86_RS21275 4874178..4875287 - 1110 WP_046974065.1 ISAs1 family transposase -
VY86_RS21280 4875328..4875732 + 405 WP_046976469.1 cytidine deaminase -
VY86_RS21285 4876042..4876326 + 285 WP_021324083.1 hypothetical protein Antitoxin
VY86_RS21290 4876326..4876604 + 279 WP_046976470.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
VY86_RS21295 4876697..4876903 - 207 WP_046976471.1 hypothetical protein -
VY86_RS21300 4876973..4877893 - 921 WP_046976472.1 hypothetical protein -
VY86_RS21305 4877890..4879485 - 1596 WP_046976473.1 hypothetical protein -
VY86_RS21310 4879556..4880479 - 924 WP_046976474.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4874178..4875287 1109


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10705.21 Da        Isoelectric Point: 5.5949

>T53372 WP_046976470.1 NZ_CP011104:4876326-4876604 [Photorhabdus thracensis]
MQLFWTPEAIQDREEIYDYIEINNPLAALALDELFSKKANCLTDHPDAGRPGRVNSTRELVIHQNYILIYDIAGETIRIL
RILHTARQWPKS

Download         Length: 279 bp

>T53372 NZ_CP011104:4876326-4876604 [Photorhabdus thracensis]
ATGCAATTATTCTGGACACCGGAGGCCATTCAAGACCGTGAAGAAATCTATGACTATATTGAGATAAATAACCCTTTAGC
AGCATTGGCTCTTGATGAACTCTTTTCAAAAAAAGCTAATTGTCTGACTGATCACCCCGATGCTGGTCGACCAGGCAGAG
TTAACAGCACCCGCGAGTTAGTAATTCACCAAAATTACATCCTAATCTATGACATTGCTGGTGAAACAATACGTATTCTC
CGTATCCTACATACCGCTAGGCAATGGCCCAAATCATAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10751.03 Da        Isoelectric Point: 9.7283

>AT53372 WP_021324083.1 NZ_CP011104:4876042-4876326 [Photorhabdus thracensis]
MSETTFTFRVDDALKNDFAAAAKSLDRKGAQLLRDFMRDFVRQQQEASAYDAWYRRQIEIGQASANAGNLVSADQVEAKF
LARREATLRRFEAK

Download         Length: 285 bp

>AT53372 NZ_CP011104:4876042-4876326 [Photorhabdus thracensis]
ATGAGCGAAACTACTTTTACCTTTCGGGTTGATGATGCTCTAAAAAATGATTTCGCCGCAGCTGCGAAATCGCTTGATCG
CAAAGGCGCACAGCTACTACGTGACTTCATGCGCGACTTTGTGCGCCAGCAACAAGAAGCGAGCGCTTATGATGCCTGGT
ACCGCAGACAAATAGAAATAGGTCAAGCTTCTGCCAATGCCGGTAATCTAGTGTCAGCTGATCAGGTTGAGGCTAAATTT
TTGGCTCGTCGTGAAGCCACACTCCGCCGTTTTGAAGCCAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F7LUE3

Antitoxin

Source ID Structure
AlphaFold DB T0P8Z0

References