Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 4760099..4760634 Replicon chromosome
Accession NZ_CP011104
Organism Photorhabdus thracensis strain DSM 15199

Toxin (Protein)


Gene name relE Uniprot ID A0A0F7LU16
Locus tag VY86_RS20725 Protein ID WP_046976388.1
Coordinates 4760347..4760634 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0F7LUB0
Locus tag VY86_RS20720 Protein ID WP_046976387.1
Coordinates 4760099..4760350 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VY86_RS20705 4756404..4757411 + 1008 WP_046976384.1 cytochrome d ubiquinol oxidase subunit II -
VY86_RS23770 4757392..4757550 + 159 WP_071881058.1 DUF2474 domain-containing protein -
VY86_RS20710 4757618..4758847 + 1230 WP_046976385.1 two-component sensor histidine kinase -
VY86_RS20715 4758899..4759822 + 924 WP_082111276.1 siderophore-interacting protein -
VY86_RS20720 4760099..4760350 + 252 WP_046976387.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
VY86_RS20725 4760347..4760634 + 288 WP_046976388.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
VY86_RS20730 4760631..4762232 - 1602 WP_046976389.1 APC family permease -
VY86_RS20735 4762340..4763923 - 1584 WP_046976390.1 aldehyde dehydrogenase (NADP(+)) -
VY86_RS20740 4763950..4764870 - 921 WP_046976391.1 dihydrodipicolinate synthase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11113.11 Da        Isoelectric Point: 10.2867

>T53371 WP_046976388.1 NZ_CP011104:4760347-4760634 [Photorhabdus thracensis]
MSYRVKFRAEAAKEWEKLDRAIQQQFAKKLKKCCDNPHIPSAKLRAMPNCYKIKLRTSGFRLVYEVIDDCLIIAVVAVGK
RERSDVYHLASERLR

Download         Length: 288 bp

>T53371 NZ_CP011104:4760347-4760634 [Photorhabdus thracensis]
ATGAGTTACCGTGTGAAGTTCAGAGCGGAAGCGGCGAAAGAATGGGAAAAACTAGATAGGGCAATACAACAGCAGTTCGC
AAAAAAACTTAAAAAATGCTGTGATAACCCGCACATACCATCAGCAAAACTTCGGGCAATGCCTAACTGTTATAAAATAA
AGTTGCGCACTTCGGGTTTCCGTCTGGTGTATGAAGTTATTGATGACTGTCTTATCATTGCCGTTGTTGCCGTGGGTAAA
CGCGAACGGAGTGATGTTTATCATCTTGCCAGCGAACGCCTGCGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9290.63 Da        Isoelectric Point: 4.5238

>AT53371 WP_046976387.1 NZ_CP011104:4760099-4760350 [Photorhabdus thracensis]
MANIILSDTSASVSELKKNPMATVKAGDGYPVAILNRNQPAFYCVPAELYEKLLDALDDQELSRLVKERQHQPLVDVDLD
KYL

Download         Length: 252 bp

>AT53371 NZ_CP011104:4760099-4760350 [Photorhabdus thracensis]
ATGGCAAACATTATTCTAAGCGACACAAGCGCAAGTGTTAGTGAATTAAAGAAAAATCCAATGGCTACTGTAAAGGCGGG
CGATGGTTATCCCGTCGCTATCCTGAACCGCAATCAGCCGGCCTTTTACTGTGTTCCAGCTGAATTATACGAAAAACTGC
TTGATGCCCTGGACGATCAGGAGTTATCGCGCCTTGTCAAAGAGCGCCAACATCAGCCATTAGTGGACGTAGATCTGGAT
AAGTACTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F7LU16

Antitoxin

Source ID Structure
AlphaFold DB A0A0F7LUB0

References