Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4752745..4753376 Replicon chromosome
Accession NZ_CP011104
Organism Photorhabdus thracensis strain DSM 15199

Toxin (Protein)


Gene name vapC Uniprot ID A0A0F7LRT9
Locus tag VY86_RS20685 Protein ID WP_046976380.1
Coordinates 4752745..4753146 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0F7LU53
Locus tag VY86_RS20690 Protein ID WP_046976381.1
Coordinates 4753146..4753376 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VY86_RS20665 4748334..4748924 + 591 WP_046976377.1 aminoacyl-tRNA hydrolase -
VY86_RS20670 4749061..4750152 + 1092 WP_046976378.1 redox-regulated ATPase YchF -
VY86_RS20675 4750854..4751660 + 807 WP_046976379.1 hypothetical protein -
VY86_RS20680 4751785..4752600 + 816 WP_158020000.1 hypothetical protein -
VY86_RS20685 4752745..4753146 - 402 WP_046976380.1 tRNA(fMet)-specific endonuclease VapC Toxin
VY86_RS20690 4753146..4753376 - 231 WP_046976381.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
VY86_RS20695 4753524..4754945 - 1422 WP_046976382.1 PLP-dependent aminotransferase family protein -
VY86_RS20700 4755077..4756414 + 1338 WP_046976383.1 cytochrome ubiquinol oxidase subunit I -
VY86_RS20705 4756404..4757411 + 1008 WP_046976384.1 cytochrome d ubiquinol oxidase subunit II -
VY86_RS23770 4757392..4757550 + 159 WP_071881058.1 DUF2474 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-33)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15056.36 Da        Isoelectric Point: 8.2877

>T53370 WP_046976380.1 NZ_CP011104:c4753146-4752745 [Photorhabdus thracensis]
MLKYMLDTCICIYTLKNRPQKVREAFLRHHGQLCISTVTLMELVKGAEKSGNPEANMKVIEEFAARLEVLNFDNRAAMHS
GQVIAELERNGLRIGAYDNQIAGHARSQGLIIVTNNVREFERVSGLRVENWAN

Download         Length: 402 bp

>T53370 NZ_CP011104:c4753146-4752745 [Photorhabdus thracensis]
ATGCTGAAATACATGCTTGATACTTGTATCTGTATCTACACTCTCAAGAACCGGCCCCAGAAGGTGCGTGAAGCTTTTCT
GCGTCATCACGGCCAATTGTGTATCAGCACGGTGACATTAATGGAACTGGTGAAAGGGGCGGAGAAATCAGGAAATCCAG
AGGCTAATATGAAGGTAATTGAGGAATTCGCTGCCAGGTTGGAAGTGTTGAATTTCGATAATAGGGCTGCTATGCACTCT
GGCCAAGTCATTGCAGAGCTTGAGCGGAACGGTTTGCGCATTGGGGCTTATGACAACCAGATAGCAGGACATGCTAGAAG
TCAAGGACTGATTATCGTTACCAACAATGTGCGTGAATTTGAGCGAGTTTCTGGTCTTCGCGTGGAGAACTGGGCCAACT
AA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8467.58 Da        Isoelectric Point: 5.0668

>AT53370 WP_046976381.1 NZ_CP011104:c4753376-4753146 [Photorhabdus thracensis]
MEQTTVFKSNRSQAVRLPKAVALPEEVKRVDVVAVGRTRIITPAGESWNSWFDGPGVTADFMAEREQPPVQEREGL

Download         Length: 231 bp

>AT53370 NZ_CP011104:c4753376-4753146 [Photorhabdus thracensis]
ATGGAGCAAACAACAGTATTTAAAAGTAACCGTTCTCAAGCAGTCAGACTTCCCAAAGCTGTAGCCCTGCCGGAAGAAGT
GAAACGCGTTGATGTGGTTGCTGTGGGTCGTACTCGTATCATTACACCAGCGGGTGAGTCTTGGAACAGCTGGTTTGATG
GTCCAGGTGTGACTGCCGATTTCATGGCAGAACGTGAACAGCCGCCAGTGCAAGAGCGTGAGGGGCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F7LRT9

Antitoxin

Source ID Structure
AlphaFold DB A0A0F7LU53

References