Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 4440962..4441722 Replicon chromosome
Accession NZ_CP011104
Organism Photorhabdus thracensis strain DSM 15199

Toxin (Protein)


Gene name ataT Uniprot ID A0A0F7LRE2
Locus tag VY86_RS19390 Protein ID WP_046976182.1
Coordinates 4440962..4441459 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID T0P817
Locus tag VY86_RS19395 Protein ID WP_021324395.1
Coordinates 4441450..4441722 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VY86_RS19365 4436029..4436469 - 441 WP_046976179.1 DUF2569 domain-containing protein -
VY86_RS19370 4436631..4437668 + 1038 WP_046976180.1 oxidoreductase -
VY86_RS19375 4437665..4438319 + 655 Protein_3846 Qnr family pentapeptide repeat protein -
VY86_RS19380 4438320..4439450 - 1131 WP_046973755.1 ISAs1 family transposase -
VY86_RS19385 4439671..4440648 + 978 WP_046976181.1 bile acid:sodium symporter -
VY86_RS19390 4440962..4441459 - 498 WP_046976182.1 GNAT family N-acetyltransferase Toxin
VY86_RS19395 4441450..4441722 - 273 WP_021324395.1 DUF1778 domain-containing protein Antitoxin
VY86_RS19400 4441848..4442816 - 969 WP_046976183.1 ExeA family protein -
VY86_RS19405 4442806..4444467 - 1662 WP_046976184.1 IS481 family transposase -
VY86_RS19410 4444451..4445011 - 561 WP_021325843.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4438320..4439450 1130


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(46-145)

Antitoxin

Vibrio phage ICP1, Orf50

(10-83)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18217.26 Da        Isoelectric Point: 9.8070

>T53369 WP_046976182.1 NZ_CP011104:c4441459-4440962 [Photorhabdus thracensis]
VGISAPEILTAEHNINNFYCQHETLNEWLLRRALKNNKLGASRTFVICKKGTKDVIGYYCLSAGSINHIESTPSLKRNMP
DPIPVVLLGRLAVDVKYQGKKLGALLLQDAWKRVASTAEQVGISAIIVHAIDESARSFYTRLGFTQSPLEPYTLMLPLGP
VKAKL

Download         Length: 498 bp

>T53369 NZ_CP011104:c4441459-4440962 [Photorhabdus thracensis]
GTGGGAATAAGCGCACCTGAAATATTAACGGCTGAACATAATATCAATAATTTTTATTGCCAGCATGAAACATTAAACGA
ATGGCTTTTGCGCCGGGCTTTAAAAAATAATAAGCTTGGCGCGAGCCGCACATTTGTTATTTGCAAAAAAGGCACAAAAG
ACGTTATTGGTTATTATTGTCTAAGCGCTGGCTCAATTAATCATATTGAATCTACACCATCACTTAAACGCAATATGCCA
GATCCTATCCCTGTGGTGCTTCTCGGTCGTCTGGCTGTCGATGTGAAGTATCAGGGGAAGAAACTAGGCGCGCTGCTTCT
CCAGGATGCCTGGAAGCGTGTCGCCAGCACGGCGGAACAAGTGGGCATTTCAGCTATAATCGTCCACGCAATTGATGAAA
GCGCCCGATCGTTCTATACGCGTCTTGGCTTCACCCAGTCACCGTTAGAGCCATATACACTGATGCTTCCATTAGGCCCA
GTGAAAGCGAAGCTATAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10521.03 Da        Isoelectric Point: 7.3586

>AT53369 WP_021324395.1 NZ_CP011104:c4441722-4441450 [Photorhabdus thracensis]
MRTQPKETPINIRAKAFQRELIDHAANLHSKTRTDFILDAACRAAEEAILDQRHFFVNEEKYHAFMQMLEQPLSDNAGFK
KLMGYKAPWE

Download         Length: 273 bp

>AT53369 NZ_CP011104:c4441722-4441450 [Photorhabdus thracensis]
ATGAGAACACAACCTAAAGAAACTCCAATTAACATCCGGGCGAAAGCCTTTCAGCGGGAGCTTATTGACCATGCGGCAAA
CCTGCATTCAAAGACCCGCACTGATTTCATTTTGGACGCTGCCTGCCGTGCAGCCGAAGAGGCCATACTCGATCAGCGTC
ACTTTTTCGTTAATGAGGAAAAATATCATGCGTTCATGCAGATGCTGGAGCAACCGCTTTCTGATAATGCAGGTTTTAAA
AAACTCATGGGATATAAAGCACCGTGGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F7LRE2

Antitoxin

Source ID Structure
AlphaFold DB T0P817

References