Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3297241..3297895 Replicon chromosome
Accession NZ_CP011104
Organism Photorhabdus thracensis strain DSM 15199

Toxin (Protein)


Gene name cptA Uniprot ID A0A0F7LQQ1
Locus tag VY86_RS14205 Protein ID WP_046975420.1
Coordinates 3297241..3297648 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0F7LM53
Locus tag VY86_RS14210 Protein ID WP_046975421.1
Coordinates 3297629..3297895 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VY86_RS14185 3293218..3294951 - 1734 WP_046975418.1 single-stranded-DNA-specific exonuclease RecJ -
VY86_RS14190 3294957..3295658 - 702 WP_046975419.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
VY86_RS14195 3295682..3296572 - 891 WP_031281031.1 site-specific tyrosine recombinase XerD -
VY86_RS14200 3296702..3297220 + 519 WP_021326192.1 flavodoxin FldB -
VY86_RS14205 3297241..3297648 - 408 WP_046975420.1 protein YgfX Toxin
VY86_RS14210 3297629..3297895 - 267 WP_046975421.1 FAD assembly factor SdhE Antitoxin
VY86_RS14215 3298072..3299061 + 990 WP_046975422.1 tRNA-modifying protein YgfZ -
VY86_RS14220 3299076..3299681 + 606 WP_046975423.1 HD domain-containing protein -
VY86_RS22640 3299777..3301051 - 1275 WP_052760849.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15981.84 Da        Isoelectric Point: 10.3447

>T53363 WP_046975420.1 NZ_CP011104:c3297648-3297241 [Photorhabdus thracensis]
VVLWKCDLRVSWNTQLISTCVHGAIAFIVLLAPWPADDSIFWLPLVLLVIASWGRSQKNIRKLQGPLVLLNNNKLQWKKH
EWQIIRQPWMCRYGVLITAQSFYNRKKIRLWIASDSMPQDEWRNINQLLLQYPDT

Download         Length: 408 bp

>T53363 NZ_CP011104:c3297648-3297241 [Photorhabdus thracensis]
GTGGTCCTGTGGAAATGTGATCTCAGGGTATCCTGGAATACCCAGCTTATTTCCACCTGCGTTCATGGTGCGATAGCGTT
TATCGTATTGTTGGCTCCGTGGCCGGCGGATGACTCTATTTTCTGGCTTCCTTTGGTACTGTTGGTTATTGCCAGTTGGG
GGCGTAGTCAGAAAAATATCCGTAAATTACAAGGGCCTTTGGTTCTACTCAATAACAATAAGTTGCAATGGAAAAAACAT
GAGTGGCAAATTATCCGCCAGCCGTGGATGTGCCGCTATGGTGTGCTGATCACAGCGCAATCTTTTTATAACCGGAAAAA
AATCCGTTTATGGATAGCATCTGATAGTATGCCACAGGATGAGTGGAGGAATATCAACCAACTGTTATTGCAATATCCTG
ATACCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10578.22 Da        Isoelectric Point: 6.7106

>AT53363 WP_046975421.1 NZ_CP011104:c3297895-3297629 [Photorhabdus thracensis]
MDINNKARIHWACRRGMRELDISIMPFFKHEYDSLSDDDKQLFIRLLECADPDLFNWLMNHGRPEDEALFRMIKLIQNRN
KARGPVEM

Download         Length: 267 bp

>AT53363 NZ_CP011104:c3297895-3297629 [Photorhabdus thracensis]
ATGGATATTAATAATAAAGCACGTATACATTGGGCATGTCGGCGTGGAATGCGTGAGTTGGATATTTCAATTATGCCGTT
TTTTAAGCATGAATATGACTCACTGAGTGATGATGATAAACAACTTTTTATTCGCTTACTTGAATGTGCTGATCCTGATC
TGTTCAACTGGTTGATGAATCATGGACGTCCGGAAGATGAGGCGCTATTCCGCATGATTAAACTTATTCAGAATAGAAAT
AAAGCTCGTGGTCCTGTGGAAATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F7LQQ1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F7LM53

References