Detailed information of TA system TA053361

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 2604201..2605114
• Replicon: chromosome
• Accession: NZ_CP011104
• Organism: Photorhabdus thracensis strain DSM 15199

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A0F7LPM0
• Locus tag: VY86_RS11230
• Protein ID: WP_046975009.1
• Coordinates: 2604644..2605114 (+)
• Length: 157 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A0F7LMM8
• Locus tag: VY86_RS11225
• Protein ID: WP_046975008.1
• Coordinates: 2604201..2604647 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
VY86_RS11205	2600215..2601420	+	1206	WP_046975005.1	MFS transporter	-
VY86_RS11210	2601687..2602121	+	435	WP_046975006.1	hypothetical protein	-
VY86_RS11215	2602494..2602757	+	264	Protein_2199	type VI secretion system tube protein Hcp	-
VY86_RS11220	2602854..2603852	+	999	WP_046975007.1	dienelactone hydrolase	-
VY86_RS11225	2604201..2604647	+	447	WP_046975008.1	DUF2384 domain-containing protein	Antitoxin
VY86_RS11230	2604644..2605114	+	471	WP_046975009.1	RES domain-containing protein	Toxin
VY86_RS11235	2605486..2606262	+	777	WP_046975010.1	SDR family oxidoreductase	-
VY86_RS11240	2606265..2606978	+	714	WP_046975011.1	hypothetical protein	-
VY86_RS11245	2606971..2607798	+	828	WP_046975012.1	cyclase family protein	-
VY86_RS11250	2608237..2609601	+	1365	WP_052760818.1	beta-ketoacyl-[acyl-carrier-protein] synthase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-133)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (30-90)

Sequences

Toxin

Protein

• Length: 157 a.a.
• Molecular weight: 17754.44 Da
• Isoelectric Point: 4.9285

>T53361 WP_046975009.1 NZ_CP011104:2604644-2605114 [Photorhabdus thracensis]
MIAYRIIKKKYKASAWTGYGAQMHGGRWNPKGCPMLYLATSISLAMLETLVHFENGALLEEYLLLSIEIDDEEIIILDRE
YLPSNWNERVIPDDTRALGNNWLNSCDSIGLIVPSVVVPQENNLLVNPQHPGFRPFLNSVIITDHLFDPRLDNMSK

Nucleotide

• Length: 471 bp

>T53361 NZ_CP011104:2604644-2605114 [Photorhabdus thracensis]
ATGATTGCGTATCGGATTATTAAGAAGAAATATAAGGCTTCAGCTTGGACAGGCTACGGGGCTCAGATGCACGGAGGCCG
TTGGAATCCAAAGGGATGCCCTATGTTATATCTTGCTACATCTATTTCTCTCGCCATGTTGGAAACGCTTGTACATTTTG
AAAATGGTGCTTTACTCGAAGAGTACCTTCTCCTAAGCATTGAGATTGATGATGAAGAAATAATCATCTTGGATAGGGAA
TATTTGCCATCAAATTGGAACGAGAGAGTTATACCTGATGATACTCGGGCGTTGGGGAATAATTGGCTGAATTCCTGTGA
TTCTATAGGTCTTATTGTGCCTTCTGTTGTCGTTCCGCAAGAGAATAACCTACTTGTTAATCCGCAGCATCCTGGTTTTC
GACCTTTCTTAAATAGTGTGATTATCACTGACCATTTATTTGATCCTCGATTAGATAACATGTCTAAGTAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16193.48 Da
• Isoelectric Point: 9.9587

>AT53361 WP_046975008.1 NZ_CP011104:2604201-2604647 [Photorhabdus thracensis]
MRTYTPSYKPVSDQLWRIVGFNASSGPNLVAQLRKGLPTSVIDEIHVWSGFKKSDILKMAGISTRNVSRRKSGPQTLSPD
QSERIARLVRVTDAAVALFEGDKDKAVNWMSKPVRGLGGETPESIIDSESGALEVLDLIGRLEHGVFS

Nucleotide

• Length: 447 bp

>AT53361 NZ_CP011104:2604201-2604647 [Photorhabdus thracensis]
ATGCGTACATATACACCATCATATAAACCGGTAAGCGATCAACTTTGGCGCATTGTTGGTTTTAATGCGAGCAGTGGGCC
GAATCTTGTCGCTCAACTCAGAAAAGGGTTGCCAACGTCTGTTATTGATGAAATTCATGTATGGTCTGGTTTTAAGAAAT
CTGACATCCTCAAGATGGCGGGAATTAGTACCAGAAATGTGTCTCGCCGAAAATCTGGGCCACAGACACTATCCCCAGAT
CAAAGCGAACGCATTGCACGCTTGGTTCGTGTGACTGATGCCGCAGTTGCCTTGTTTGAGGGTGATAAAGATAAAGCAGT
TAATTGGATGAGTAAGCCTGTCCGAGGTCTCGGCGGTGAAACACCAGAAAGTATAATTGATTCTGAAAGCGGTGCATTGG
AAGTGTTGGATCTTATTGGCCGACTGGAGCATGGCGTTTTCTCATGA

Structures

Toxin

• AlphaFold DB: A0A0F7LPM0

Antitoxin

• AlphaFold DB: A0A0F7LMM8