Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 2496763..2497556 Replicon chromosome
Accession NZ_CP011104
Organism Photorhabdus thracensis strain DSM 15199

Toxin (Protein)


Gene name - Uniprot ID A0A0F7LPI8
Locus tag VY86_RS10780 Protein ID WP_046974941.1
Coordinates 2496763..2497290 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0F7LNY4
Locus tag VY86_RS10785 Protein ID WP_046974942.1
Coordinates 2497287..2497556 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VY86_RS10765 2492503..2492925 + 423 WP_046974938.1 cupin domain-containing protein -
VY86_RS10770 2494188..2495000 - 813 WP_046974939.1 nucleotidyltransferase domain-containing protein -
VY86_RS10775 2495006..2495524 - 519 WP_082111308.1 RtcB family protein -
VY86_RS10780 2496763..2497290 - 528 WP_046974941.1 GNAT family N-acetyltransferase Toxin
VY86_RS10785 2497287..2497556 - 270 WP_046974942.1 DUF1778 domain-containing protein Antitoxin
VY86_RS10790 2497670..2499424 - 1755 WP_046976817.1 biotin/lipoyl-binding protein -
VY86_RS10795 2499460..2501073 - 1614 WP_046974943.1 5-oxoprolinase/urea amidolyase family protein -
VY86_RS10800 2501126..2501896 - 771 WP_046974944.1 LamB/YcsF family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(5-81)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 20089.39 Da        Isoelectric Point: 8.5945

>T53360 WP_046974941.1 NZ_CP011104:c2497290-2496763 [Photorhabdus thracensis]
VSWSKSFIELNKKTHDRLAFDCSEYELNTFIKTQAAKHMQAGISRTMVLPATTTLPNQLYPICSFYCVAPSSIERDTLPK
EQAKKLPHYPILVFLLAQLAVHKTYHGQGLGKITLIKSLEYLWEINHHMPAYAVIVDCLNDADQTFYSQYGFELLCNQKN
KARLFLPMKTISQIF

Download         Length: 528 bp

>T53360 NZ_CP011104:c2497290-2496763 [Photorhabdus thracensis]
GTGAGCTGGTCTAAGTCATTCATTGAGCTAAATAAAAAAACGCATGATCGTTTAGCCTTTGATTGTAGCGAGTATGAACT
CAACACTTTCATTAAAACTCAGGCAGCAAAGCACATGCAGGCAGGTATCAGCCGTACAATGGTTTTACCTGCCACGACAA
CTTTACCAAATCAGCTTTATCCCATTTGTTCATTTTATTGTGTAGCGCCAAGTTCTATTGAAAGAGATACGCTTCCGAAG
GAACAAGCAAAGAAACTACCACACTACCCCATACTTGTATTTTTGTTAGCTCAATTAGCTGTACATAAAACTTATCATGG
TCAGGGATTAGGGAAAATTACTCTTATAAAATCACTCGAATACCTTTGGGAAATTAATCATCATATGCCTGCGTATGCGG
TAATTGTTGACTGCCTAAATGATGCTGATCAGACATTTTATTCTCAATATGGTTTTGAACTCTTATGCAATCAAAAGAAT
AAAGCTCGTTTATTCTTACCCATGAAAACGATTTCTCAAATTTTTTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10123.80 Da        Isoelectric Point: 8.9642

>AT53360 WP_046974942.1 NZ_CP011104:c2497556-2497287 [Photorhabdus thracensis]
MVTARLDLRLDEEIKAKAEKASALLGMKSLTEYVVHLMQRDANQVISEYERMTIKGDIFDHFVNACKQAKKPNKALLNAV
AFTKEQEVK

Download         Length: 270 bp

>AT53360 NZ_CP011104:c2497556-2497287 [Photorhabdus thracensis]
ATGGTTACAGCAAGATTAGATTTGCGCCTGGATGAAGAGATTAAAGCGAAAGCAGAGAAAGCATCTGCACTATTAGGTAT
GAAAAGCCTGACAGAGTATGTTGTACATCTGATGCAAAGAGATGCTAATCAAGTCATTTCTGAATACGAAAGAATGACTA
TTAAAGGTGATATTTTTGATCATTTCGTCAATGCCTGCAAACAGGCTAAAAAACCGAATAAAGCATTATTAAACGCGGTT
GCCTTTACTAAAGAGCAGGAAGTCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F7LPI8

Antitoxin

Source ID Structure
AlphaFold DB A0A0F7LNY4

References