Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 2037458..2038147 Replicon chromosome
Accession NZ_CP011104
Organism Photorhabdus thracensis strain DSM 15199

Toxin (Protein)


Gene name ykfI Uniprot ID A0A0F7LJV5
Locus tag VY86_RS08685 Protein ID WP_046974663.1
Coordinates 2037809..2038147 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A0F7LN01
Locus tag VY86_RS08680 Protein ID WP_046974662.1
Coordinates 2037458..2037784 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VY86_RS08655 2033478..2034386 + 909 WP_046974658.1 hypothetical protein -
VY86_RS08660 2034465..2034824 - 360 Protein_1695 IS630 family transposase -
VY86_RS08665 2034963..2036000 - 1038 WP_046976644.1 IS5 family transposase -
VY86_RS08670 2036083..2036766 - 684 Protein_1697 IS630-like element ISPlu16 family transposase -
VY86_RS08675 2036942..2037415 + 474 WP_046974661.1 DNA repair protein RadC -
VY86_RS08680 2037458..2037784 + 327 WP_046974662.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
VY86_RS08685 2037809..2038147 + 339 WP_046974663.1 TA system toxin CbtA family protein Toxin
VY86_RS24050 2039049..2039397 + 349 Protein_1701 winged helix-turn-helix domain-containing protein -
VY86_RS08695 2039668..2040672 - 1005 WP_046973747.1 IS110 family transposase -
VY86_RS08700 2040743..2041378 + 636 Protein_1703 IS630 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 2034465..2041378 6913


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-107)

Antitoxin

Antitoxin CbeA

(7-107)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12910.80 Da        Isoelectric Point: 8.9452

>T53358 WP_046974663.1 NZ_CP011104:2037809-2038147 [Photorhabdus thracensis]
MTTFPANQRVAKPCPPPVLVWQTLLTRLLEQHYGLTLNDTPFSDETVIQEHINAGITLADAVNFLVEKYELVRIDRRGFS
WQEQSPYLRAVDILRARQATGLLRQSYNLSKR

Download         Length: 339 bp

>T53358 NZ_CP011104:2037809-2038147 [Photorhabdus thracensis]
ATGACAACTTTTCCTGCAAATCAGCGGGTGGCGAAGCCATGCCCGCCGCCTGTGCTTGTCTGGCAAACTCTACTTACACG
CCTGCTGGAGCAACACTATGGCCTGACGCTGAACGACACGCCTTTCAGTGATGAAACCGTTATTCAGGAGCATATCAACG
CCGGTATTACATTGGCTGATGCCGTTAACTTTCTGGTGGAAAAATACGAACTGGTTCGTATCGATCGCAGGGGATTTAGC
TGGCAGGAACAATCGCCTTATCTTCGGGCTGTAGACATTTTGCGGGCACGACAGGCAACGGGTCTGTTACGACAAAGCTA
TAATCTTTCGAAACGCTGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12569.27 Da        Isoelectric Point: 6.7444

>AT53358 WP_046974662.1 NZ_CP011104:2037458-2037784 [Photorhabdus thracensis]
MEKHDNPEWGLRCDVMPRFTARLVQEGNRLHYLADRAGISGTFNEEKCHQLNAAFPHFIKQMELMLLSGELNPRHAHRIT
LYNNELTCEADTLSSYGYVYIAIYPTQR

Download         Length: 327 bp

>AT53358 NZ_CP011104:2037458-2037784 [Photorhabdus thracensis]
ATGGAAAAACACGATAACCCTGAATGGGGGCTTCGGTGCGATGTAATGCCTCGCTTTACCGCAAGGTTAGTACAGGAAGG
CAATCGACTACATTATTTAGCTGACCGCGCCGGGATAAGTGGCACTTTCAATGAGGAAAAGTGCCACCAACTGAATGCCG
CATTTCCACACTTTATTAAACAGATGGAGCTGATGCTGCTCTCTGGTGAGCTTAACCCTCGCCATGCACACCGTATAACG
CTGTACAACAACGAACTGACCTGTGAAGCGGATACGCTCAGTAGCTATGGCTACGTTTATATCGCTATCTATCCCACTCA
ACGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F7LJV5

Antitoxin

Source ID Structure
AlphaFold DB A0A0F7LN01

References