Detailed information of TA system TA053357

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-dinJ/YafQ-RelB
• Location: 1830194..1830648
• Replicon: chromosome
• Accession: NZ_CP011104
• Organism: Photorhabdus thracensis strain DSM 15199

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: VY86_RS07695
• Protein ID: WP_082111195.1
• Coordinates: 1830194..1830397 (-)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: A0A0F7LMF6
• Locus tag: VY86_RS07700
• Protein ID: WP_046974526.1
• Coordinates: 1830391..1830648 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
VY86_RS07680	1826418..1827455	-	1038	WP_046976644.1	IS5 family transposase	-
VY86_RS07685	1827655..1828647	+	993	WP_046974525.1	acyltransferase family protein	-
VY86_RS07690	1829132..1830151	+	1020	WP_046976757.1	UDP-glucose 4-epimerase GalE	-
VY86_RS07695	1830194..1830397	-	204	WP_082111195.1	type II toxin-antitoxin system YafQ family toxin	Toxin
VY86_RS07700	1830391..1830648	-	258	WP_046974526.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
VY86_RS07705	1830826..1831314	+	489	WP_046974527.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
VY86_RS07710	1831424..1832245	-	822	WP_046974528.1	serine O-acetyltransferase	-
VY86_RS07715	1832298..1833320	-	1023	WP_046974529.1	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase	-
VY86_RS07720	1833320..1833796	-	477	WP_021324088.1	protein-export chaperone SecB	-
VY86_RS07725	1833866..1834303	-	438	WP_036845497.1	rhodanese-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	bplB / neuD / neuB / rfaD	1697422..1932158	234736

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-67)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-78)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 7759.93 Da
• Isoelectric Point: 7.2738

>T53357 WP_082111195.1 NZ_CP011104:c1830397-1830194 [Photorhabdus thracensis]
MVNKAQLKTIELLQTGEPLPERYREHSLAGQYIGYLECHGAPDILLIYQRKNTELKLYRVGSHSDLF

Nucleotide

• Length: 204 bp

>T53357 NZ_CP011104:c1830397-1830194 [Photorhabdus thracensis]
ATGGTAAATAAAGCTCAATTGAAAACCATTGAGCTTTTACAGACTGGTGAACCTTTACCAGAGCGTTACCGTGAACATTC
ATTAGCAGGCCAATATATTGGCTACCTTGAATGCCACGGAGCGCCTGATATTTTGCTTATTTATCAGCGTAAAAATACTG
AATTGAAACTATATCGAGTAGGTAGTCATTCAGATTTATTCTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9418.92 Da
• Isoelectric Point: 5.8152

>AT53357 WP_046974526.1 NZ_CP011104:c1830648-1830391 [Photorhabdus thracensis]
MADTVVRARINPKSKAAAMANAKAMGLNLSTIIRMVVNRLAVEPELPDELLQLNQETLQAIRDLENGVGVHRVDTIDELK
RDLGW

Nucleotide

• Length: 258 bp

>AT53357 NZ_CP011104:c1830648-1830391 [Photorhabdus thracensis]
ATGGCTGATACCGTTGTACGTGCCCGTATTAATCCTAAATCCAAAGCGGCGGCGATGGCTAATGCGAAAGCGATGGGGCT
GAATCTTTCCACTATAATTCGTATGGTGGTTAATCGTTTGGCTGTTGAGCCAGAATTACCTGATGAGTTGTTGCAACTTA
ATCAGGAGACATTACAGGCTATTCGAGATCTGGAAAATGGCGTAGGTGTTCACCGAGTTGATACGATAGATGAACTAAAG
CGTGATCTTGGATGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0F7LMF6