Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-RelB
Location 1458751..1459256 Replicon chromosome
Accession NZ_CP011104
Organism Photorhabdus thracensis strain DSM 15199

Toxin (Protein)


Gene name relB Uniprot ID A0A0F7LM01
Locus tag VY86_RS05785 Protein ID WP_046974257.1
Coordinates 1458751..1459005 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relE Uniprot ID A0A0F7LM75
Locus tag VY86_RS05790 Protein ID WP_046974258.1
Coordinates 1459002..1459256 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VY86_RS05775 1454045..1456453 + 2409 WP_046974255.1 maltodextrin phosphorylase -
VY86_RS05780 1456463..1458550 + 2088 WP_046974256.1 4-alpha-glucanotransferase -
VY86_RS05785 1458751..1459005 - 255 WP_046974257.1 Txe/YoeB family addiction module toxin Toxin
VY86_RS05790 1459002..1459256 - 255 WP_046974258.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
VY86_RS05795 1460415..1462430 + 2016 WP_046974259.1 alkaline phosphatase family protein -
VY86_RS05800 1462608..1463323 - 716 Protein_1137 transposase -
VY86_RS05805 1463401..1463607 - 207 WP_046974260.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1462608..1463003 395


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10314.89 Da        Isoelectric Point: 9.4097

>T53355 WP_046974257.1 NZ_CP011104:c1459005-1458751 [Photorhabdus thracensis]
MILSWAEMAWEDYLHWQQTDKKILKRVNTLIKDIKRQPFGGLGDPEPLKHNWSGYWSRRIDREHRLVYKVTDETIIIVQC
RYHY

Download         Length: 255 bp

>T53355 NZ_CP011104:c1459005-1458751 [Photorhabdus thracensis]
ATGATTTTATCTTGGGCGGAAATGGCATGGGAGGATTATCTGCATTGGCAACAGACCGATAAAAAAATCTTAAAGCGCGT
AAATACGTTAATTAAAGATATTAAACGGCAGCCCTTTGGTGGGCTTGGTGATCCAGAGCCACTAAAGCATAATTGGTCGG
GATATTGGTCCAGGCGGATTGATCGAGAACATCGCCTAGTTTACAAGGTGACAGACGAAACAATCATTATTGTGCAATGC
CGTTACCACTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9317.53 Da        Isoelectric Point: 5.0790

>AT53355 WP_046974258.1 NZ_CP011104:c1459256-1459002 [Photorhabdus thracensis]
MNTMSYSAFRANLARTLDKVNDDHKPVIITRQNGKPAVVISLEDFQSYEETAYLMASTKNAARLNQAIAEVEAGKTVEKG
LLEE

Download         Length: 255 bp

>AT53355 NZ_CP011104:c1459256-1459002 [Photorhabdus thracensis]
ATGAATACGATGAGTTATTCAGCATTCCGGGCTAACTTGGCTAGAACCCTGGATAAAGTGAATGATGACCACAAGCCCGT
TATCATCACTCGCCAGAACGGTAAACCAGCTGTCGTTATTAGCCTGGAAGATTTCCAGTCTTACGAAGAGACGGCCTACT
TGATGGCCAGCACCAAAAATGCTGCTCGTTTGAACCAGGCTATCGCGGAAGTGGAGGCCGGTAAAACCGTTGAGAAAGGA
TTATTGGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F7LM01

Antitoxin

Source ID Structure
AlphaFold DB A0A0F7LM75

References