Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 1385176..1385811 Replicon chromosome
Accession NZ_CP011104
Organism Photorhabdus thracensis strain DSM 15199

Toxin (Protein)


Gene name hicA Uniprot ID U7R1C4
Locus tag VY86_RS05495 Protein ID WP_023044500.1
Coordinates 1385635..1385811 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0F7LLF5
Locus tag VY86_RS05490 Protein ID WP_046974212.1
Coordinates 1385176..1385583 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VY86_RS05465 1380394..1381473 + 1080 WP_046974207.1 alanine racemase -
VY86_RS05470 1381527..1382723 + 1197 WP_046974208.1 aspartate/tyrosine/aromatic aminotransferase -
VY86_RS05475 1383061..1383621 + 561 WP_046974209.1 hypothetical protein -
VY86_RS05480 1383602..1384843 + 1242 WP_046974210.1 hypothetical protein -
VY86_RS05485 1384852..1385106 + 255 WP_046974211.1 cloacin immunity family protein -
VY86_RS05490 1385176..1385583 - 408 WP_046974212.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
VY86_RS05495 1385635..1385811 - 177 WP_023044500.1 type II toxin-antitoxin system HicA family toxin Toxin
VY86_RS05500 1386376..1387467 + 1092 WP_046974213.1 winged helix-turn-helix transcriptional regulator -
VY86_RS05505 1387464..1388402 + 939 WP_046974214.1 pseudouridine-5'-phosphate glycosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-60)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6725.91 Da        Isoelectric Point: 11.2826

>T53354 WP_023044500.1 NZ_CP011104:c1385811-1385635 [Photorhabdus thracensis]
VKQSEFRRWLKAQGAEFKDGTNHLKVFLNGKQTTMPRHPSKEIPEPLRKAILKQLGIK

Download         Length: 177 bp

>T53354 NZ_CP011104:c1385811-1385635 [Photorhabdus thracensis]
GTGAAGCAAAGCGAGTTTCGCCGGTGGCTTAAAGCTCAAGGAGCAGAATTTAAAGATGGGACTAATCATCTGAAAGTTTT
CTTGAACGGTAAGCAAACCACGATGCCAAGGCACCCTAGTAAAGAAATCCCAGAACCACTAAGGAAAGCAATATTAAAAC
AGCTAGGCATCAAATAA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14920.16 Da        Isoelectric Point: 4.9535

>AT53354 WP_046974212.1 NZ_CP011104:c1385583-1385176 [Photorhabdus thracensis]
MRYPVKFEHDETGWAVMFPDIPEALTGGDTREEALAMARDALVTAFDFYFEDRRKIPAPSLEGEAFVEVPASIAAKVLLL
NTMLQTRTSNAELARLLGTRPQEIQRIVSLGHSTKIDTIANALNALGKHLELIAI

Download         Length: 408 bp

>AT53354 NZ_CP011104:c1385583-1385176 [Photorhabdus thracensis]
ATGCGATACCCAGTAAAATTCGAACATGACGAAACAGGTTGGGCTGTGATGTTCCCAGATATCCCTGAAGCCTTAACAGG
TGGAGATACCAGAGAAGAAGCGTTAGCTATGGCGCGGGATGCTCTGGTTACTGCATTTGATTTCTACTTTGAAGACCGGC
GCAAAATACCAGCACCGTCGCTTGAAGGAGAAGCTTTTGTCGAAGTACCGGCTAGTATAGCGGCTAAAGTTTTGCTGTTG
AATACGATGCTTCAAACAAGAACAAGCAATGCGGAGCTTGCACGGTTACTAGGCACCCGACCGCAAGAAATCCAACGTAT
AGTGTCATTAGGTCATAGTACTAAAATTGACACTATAGCGAATGCGTTAAATGCCTTAGGAAAGCATCTGGAACTTATTG
CCATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U7R1C4

Antitoxin

Source ID Structure
AlphaFold DB A0A0F7LLF5

References