Detailed information of TA system TA053349

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 2222322..2222814
• Replicon: chromosome
• Accession: NZ_CP011102
• Organism: Listeria weihenstephanensis strain WS 4560

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: UE46_RS10800
• Protein ID: WP_051493052.1
• Coordinates: 2222596..2222814 (+)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: W7CFX1
• Locus tag: UE46_RS10795
• Protein ID: WP_036062806.1
• Coordinates: 2222322..2222543 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
UE46_RS10775	2218784..2219677	+	894	WP_036062800.1	LysR family transcriptional regulator	-
UE46_RS10780	2219688..2220248	-	561	WP_051493051.1	TetR/AcrR family transcriptional regulator	-
UE46_RS10785	2220386..2221222	+	837	WP_036062802.1	alpha/beta hydrolase	-
UE46_RS10790	2221238..2222182	+	945	WP_036062804.1	amidohydrolase family protein	-
UE46_RS10795	2222322..2222543	+	222	WP_036062806.1	toxin-antitoxin system antitoxin subunit	Antitoxin
UE46_RS10800	2222596..2222814	+	219	WP_051493052.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
UE46_RS10805	2222981..2223610	-	630	WP_036062808.1	plasmid pRiA4b ORF-3 family protein	-
UE46_RS10810	2223733..2224167	-	435	WP_036062812.1	hypothetical protein	-
UE46_RS10815	2224333..2224860	-	528	WP_036062815.1	hypothetical protein	-
UE46_RS10820	2224899..2225297	-	399	WP_036062817.1	DUF4279 domain-containing protein	-
UE46_RS10825	2225325..2225663	-	339	WP_036062819.1	hypothetical protein	-
UE46_RS10830	2225676..2226170	-	495	WP_036062823.1	hypothetical protein	-
UE46_RS10835	2226155..2226415	-	261	WP_036062872.1	hypothetical protein	-
UE46_RS10840	2226595..2227107	-	513	WP_143812882.1	hypothetical protein	-
UE46_RS10845	2227230..2227709	-	480	WP_036062829.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-70)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8559.96 Da
• Isoelectric Point: 10.6599

>T53349 WP_051493052.1 NZ_CP011102:2222596-2222814 [Listeria weihenstephanensis]
MDRFQAKLLVSWIEKHLEGTKNPRVHGKSRVGNRGGQWRYRVGDYRLIAEIKDDEIVILILNIGHRRMIYDK

Nucleotide

• Length: 219 bp

>T53349 NZ_CP011102:2222596-2222814 [Listeria weihenstephanensis]
ATGGATCGTTTTCAGGCAAAGCTCCTTGTTTCATGGATTGAAAAACATTTAGAGGGAACAAAAAATCCACGTGTGCACGG
AAAGAGCCGTGTTGGAAATCGCGGTGGACAATGGCGGTATCGAGTTGGTGATTATCGATTAATCGCGGAAATTAAAGATG
ATGAAATCGTTATTTTGATTCTAAACATCGGGCATCGTCGCATGATCTATGACAAATAG

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8400.49 Da
• Isoelectric Point: 4.4475

>AT53349 WP_036062806.1 NZ_CP011102:2222322-2222543 [Listeria weihenstephanensis]
MTTITFRVSDEEKEFIQKMAEFNGISVSELSRNQILESLENQIDLDLYKSALQAHHAKDESLSLQEMKKALDL

Nucleotide

• Length: 222 bp

>AT53349 NZ_CP011102:2222322-2222543 [Listeria weihenstephanensis]
ATGACAACTATCACATTCCGCGTTTCTGATGAAGAAAAAGAATTCATCCAAAAAATGGCCGAGTTTAATGGAATTTCTGT
ATCTGAACTCAGTCGAAATCAAATTCTTGAAAGCTTAGAAAATCAAATCGACTTAGACCTATACAAAAGCGCACTGCAAG
CCCATCATGCGAAAGATGAAAGCCTCTCTCTTCAAGAGATGAAAAAGGCACTTGATTTATGA

Structures

Antitoxin

• AlphaFold DB: A0A1S7FVR7