Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 2201906..2202556 Replicon chromosome
Accession NZ_CP011098
Organism Mannheimia haemolytica strain 89010807N isolate laboratory frozen stock

Toxin (Protein)


Gene name vapC Uniprot ID A0A547EDJ6
Locus tag WC39_RS11210 Protein ID WP_006249411.1
Coordinates 2201906..2202295 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A547EDM1
Locus tag WC39_RS11215 Protein ID WP_006249412.1
Coordinates 2202296..2202556 (-) Length 87 a.a.

Genomic Context

WC39_RS11155WC39_RS11160WC39_RS11165WC39_RS11205WC39_RS11210WC39_RS11215WC39_RS11220WC39_RS11225WC39_RS11230
Location: 2197177..2197986 (810 bp)
Type: Others
Protein ID: WP_006250123.1
Location: 2197979..2198839 (861 bp)
Type: Others
Protein ID: WP_006250124.1
Location: 2198913..2199698 (786 bp)
Type: Others
Protein ID: WP_006251768.1
Location: 2200648..2201886 (1239 bp)
Type: Others
Protein ID: WP_006253630.1
Location: 2201906..2202295 (390 bp)
Type: Toxin
Protein ID: WP_006249411.1
Location: 2202296..2202556 (261 bp)
Type: Antitoxin
Protein ID: WP_006249412.1
Location: 2202672..2202884 (213 bp)
Type: Others
Protein ID: WP_006251765.1
Location: 2202885..2203172 (288 bp)
Type: Others
Protein ID: WP_006251764.1
Location: 2203335..2206868 (3534 bp)
Type: Others
Protein ID: WP_006253629.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
WC39_RS111552197177..2197986-810WP_006250123.1metal ABC transporter permease-
WC39_RS111602197979..2198839-861WP_006250124.1metal ABC transporter permease-
WC39_RS111652198913..2199698-786WP_006251768.1hypothetical protein-
WC39_RS112052200648..2201886-1239WP_006253630.1peptidase T-
WC39_RS112102201906..2202295-390WP_006249411.1type II toxin-antitoxin system VapC family toxinToxin
WC39_RS112152202296..2202556-261WP_006249412.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
WC39_RS112202202672..2202884-213WP_006251765.1BrnA antitoxin family protein-
WC39_RS112252202885..2203172-288WP_006251764.1BrnT family toxin-
WC39_RS112302203335..2206868-3534WP_006253629.1transcription-repair coupling factor-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14633.91 Da        Isoelectric Point: 7.1041

>T53332 WP_006249411.1 NZ_CP011098:c2202295-2201906 [Mannheimia haemolytica]
MYMLDTNTVSYFFRGNANVVAKLKSINPERLCISSVTAAELVYGVAKRNNGQLSQFLDYFLSSVKVLDWNYRCAELYGKL
RAEMEKNGKVMGVQDQMIASHALAEECILVSSDQAFKMVPDLKLENWLH

Download         Length: 390 bp

>T53332 NZ_CP011098:c2202295-2201906 [Mannheimia haemolytica]
ATGTATATGTTAGATACGAATACTGTAAGCTATTTTTTTCGTGGAAATGCAAATGTGGTGGCGAAATTGAAGTCCATTAA
TCCTGAGAGGCTTTGTATTTCATCTGTAACTGCTGCTGAATTGGTTTATGGTGTGGCGAAAAGAAATAATGGGCAGCTTT
CTCAATTTTTAGATTATTTTTTATCGAGTGTAAAGGTTTTAGATTGGAATTATCGTTGTGCTGAACTTTATGGAAAGTTA
CGGGCAGAGATGGAGAAAAATGGCAAAGTAATGGGCGTGCAGGATCAAATGATTGCTAGTCACGCTCTTGCTGAAGAGTG
TATTTTAGTTTCTAGTGATCAGGCATTTAAAATGGTACCTGATCTGAAATTGGAGAATTGGTTACACTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10245.54 Da        Isoelectric Point: 4.8951

>AT53332 WP_006249412.1 NZ_CP011098:c2202556-2202296 [Mannheimia haemolytica]
MEKIARLFRNGRNQAVRLPVEFEFDAEQVYVSKKENGDILLSLRSRNTEHWQRLFELLPAVVCDETFLDTKERNQSFEQR
DPFEVA

Download         Length: 261 bp

>AT53332 NZ_CP011098:c2202556-2202296 [Mannheimia haemolytica]
ATGGAAAAAATTGCGAGATTATTCCGTAACGGGCGGAACCAAGCAGTGCGTTTACCGGTTGAATTTGAGTTTGATGCAGA
GCAAGTCTATGTTTCTAAAAAAGAAAATGGCGATATTTTATTATCATTGAGATCGAGAAATACCGAGCATTGGCAACGAT
TGTTTGAGCTATTGCCTGCTGTTGTATGTGATGAAACATTTTTAGATACAAAAGAGAGAAACCAATCCTTTGAGCAACGG
GATCCTTTTGAGGTAGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A547EDJ6

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A547EDM1

References