Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 1109054..1109694 Replicon chromosome
Accession NZ_CP011098
Organism Mannheimia haemolytica strain 89010807N isolate laboratory frozen stock

Toxin (Protein)


Gene name hicA Uniprot ID A0A378NFX7
Locus tag WC39_RS05665 Protein ID WP_006250075.1
Coordinates 1109054..1109236 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A378NFW9
Locus tag WC39_RS05670 Protein ID WP_006250074.1
Coordinates 1109275..1109694 (+) Length 140 a.a.

Genomic Context

WC39_RS05630WC39_RS05635WC39_RS05650WC39_RS05655WC39_RS05660WC39_RS05665WC39_RS05670WC39_RS05675WC39_RS05680WC39_RS05625WC39_RS14430WC39_RS14550WC39_RS05645WC39_RS05685WC39_RS05690
Location: 1105038..1105427 (390 bp)
Type: Others
Protein ID: WP_015484247.1
Location: 1105399..1105698 (300 bp)
Type: Others
Protein ID: WP_006247810.1
Location: 1107294..1107977 (684 bp)
Type: Others
Protein ID: WP_006248824.1
Location: 1108052..1108432 (381 bp)
Type: Others
Protein ID: WP_006248823.1
Location: 1108437..1108922 (486 bp)
Type: Others
Protein ID: WP_015484250.1
Location: 1109054..1109236 (183 bp)
Type: Toxin
Protein ID: WP_006250075.1
Location: 1109275..1109694 (420 bp)
Type: Antitoxin
Protein ID: WP_006250074.1
Location: 1110030..1110674 (645 bp)
Type: Others
Protein ID: WP_006253274.1
Location: 1110812..1111852 (1041 bp)
Type: Others
Protein ID: WP_015586960.1
Location: 1104601..1104894 (294 bp)
Type: Others
Protein ID: WP_006247812.1
Location: 1105707..1105865 (159 bp)
Type: Others
Protein ID: WP_006247809.1
Location: 1105875..1106942 (1068 bp)
Type: Others
Protein ID: WP_006253284.1
Location: 1106963..1107163 (201 bp)
Type: Others
Protein ID: WP_006248825.1
Location: 1111919..1113325 (1407 bp)
Type: Others
Protein ID: WP_006253513.1
Location: 1113375..1114181 (807 bp)
Type: Others
Protein ID: WP_006248821.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
WC39_RS056251104601..1104894-294WP_006247812.1hypothetical protein-
WC39_RS056301105038..1105427+390WP_015484247.1type II toxin-antitoxin system RelE/ParE family toxin-
WC39_RS056351105399..1105698+300WP_006247810.1XRE family transcriptional regulator-
WC39_RS144301105707..1105865-159WP_006247809.1hypothetical protein-
WC39_RS145501105875..1106942-1068WP_006253284.1hypothetical protein-
WC39_RS056451106963..1107163-201WP_006248825.1helix-turn-helix domain-containing protein-
WC39_RS056501107294..1107977+684WP_006248824.1helix-turn-helix transcriptional regulator-
WC39_RS056551108052..1108432+381WP_006248823.1hypothetical protein-
WC39_RS056601108437..1108922+486WP_015484250.1hypothetical protein-
WC39_RS056651109054..1109236+183WP_006250075.1type II toxin-antitoxin system HicA family toxinToxin
WC39_RS056701109275..1109694+420WP_006250074.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
WC39_RS056751110030..1110674+645WP_006253274.1tyrosine-type recombinase/integrase-
WC39_RS056801110812..1111852+1041WP_015586960.1IS481 family transposase-
WC39_RS056851111919..1113325-1407WP_006253513.1YdgA family protein-
WC39_RS056901113375..1114181-807WP_006248821.1tryptophan synthase subunit alpha-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-flankIS/Tn--1110812..11118521040


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-96)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6933.03 Da        Isoelectric Point: 10.3446

>T53330 WP_006250075.1 NZ_CP011098:1109054-1109236 [Mannheimia haemolytica]
MKYSEFLRYLLAQGCEIENHRRGSHRKVTLNGKQSVFPYHGSKEIGTGLVNKIKKDLDLK

Download         Length: 183 bp

>T53330 NZ_CP011098:1109054-1109236 [Mannheimia haemolytica]
ATGAAATACAGCGAGTTCCTGAGGTACTTACTTGCTCAAGGTTGCGAAATTGAAAACCATAGGCGAGGCAGTCATCGAAA
GGTAACACTAAACGGAAAACAATCGGTTTTTCCTTATCACGGGAGCAAAGAGATTGGTACAGGTTTAGTAAATAAGATTA
AGAAAGACTTAGATCTTAAATAA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15938.30 Da        Isoelectric Point: 4.6963

>AT53330 WP_006250074.1 NZ_CP011098:1109275-1109694 [Mannheimia haemolytica]
MLRYPVEITPDDNGTYLVTCPDIPEMASVGEDLEEALLEAQDGLATALEFYFDDRREIPMPSPIKEGQHTVNLTVLQSMK
VFLLNEMIKQGVRKAEMARRLDVHLPQIDRLLDFNHSTKVEFVEKAYGKLNQHFTILPH

Download         Length: 420 bp

>AT53330 NZ_CP011098:1109275-1109694 [Mannheimia haemolytica]
ATGTTACGCTACCCAGTTGAAATTACCCCTGATGATAACGGCACATATCTTGTGACTTGCCCTGATATTCCTGAAATGGC
AAGCGTAGGTGAGGACTTAGAAGAAGCCCTATTAGAAGCACAAGATGGCTTAGCCACAGCCCTTGAATTCTATTTTGATG
ATAGACGAGAAATACCAATGCCAAGCCCAATTAAAGAGGGACAACATACGGTTAATCTTACCGTGCTGCAATCAATGAAA
GTATTTCTCTTAAATGAAATGATTAAACAAGGTGTACGCAAAGCAGAAATGGCAAGACGATTAGATGTACACTTACCACA
GATAGATCGCCTATTAGATTTTAATCATTCCACAAAAGTAGAATTTGTTGAGAAAGCCTATGGTAAGCTAAATCAACACT
TTACTATTCTCCCTCACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A378NFX7

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A378NFW9

References