Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 885827..886366 Replicon chromosome
Accession NZ_CP011098
Organism Mannheimia haemolytica strain 89010807N isolate laboratory frozen stock

Toxin (Protein)


Gene name relE Uniprot ID A0A248ZYA9
Locus tag WC39_RS04470 Protein ID WP_006247804.1
Coordinates 885827..886096 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A547E920
Locus tag WC39_RS04475 Protein ID WP_006247803.1
Coordinates 886100..886366 (-) Length 89 a.a.

Genomic Context

WC39_RS04425WC39_RS04500WC39_RS04505WC39_RS13860WC39_RS04510WC39_RS04515WC39_RS14415WC39_RS04430WC39_RS04435WC39_RS04440WC39_RS04450WC39_RS04455WC39_RS04460WC39_RS04465WC39_RS04470WC39_RS04475WC39_RS04480WC39_RS04485WC39_RS04490WC39_RS04495WC39_RS13855
Location: 880961..881260 (300 bp)
Type: Others
Protein ID: WP_006247810.1
Location: 888663..889037 (375 bp)
Type: Others
Protein ID: WP_006247798.1
Location: 889045..889212 (168 bp)
Type: Others
Protein ID: WP_006253314.1
Location: 889293..889616 (324 bp)
Type: Others
Protein ID: WP_006253316.1
Location: 889520..890230 (711 bp)
Type: Others
Protein ID: Protein_852
Location: 890331..890966 (636 bp)
Type: Others
Protein ID: Protein_853
Location: 881269..881427 (159 bp)
Type: Others
Protein ID: WP_006247809.1
Location: 881437..882123 (687 bp)
Type: Others
Protein ID: WP_006247808.1
Location: 882234..882845 (612 bp)
Type: Others
Protein ID: WP_006253310.1
Location: 882894..883520 (627 bp)
Type: Others
Protein ID: WP_006247807.1
Location: 883742..884461 (720 bp)
Type: Others
Protein ID: WP_006247806.1
Location: 884451..884741 (291 bp)
Type: Others
Protein ID: Protein_839
Location: 884719..885429 (711 bp)
Type: Others
Protein ID: WP_006253312.1
Location: 885489..885752 (264 bp)
Type: Others
Protein ID: WP_006247805.1
Location: 885827..886096 (270 bp)
Type: Toxin
Protein ID: WP_006247804.1
Location: 886100..886366 (267 bp)
Type: Antitoxin
Protein ID: WP_006247803.1
Location: 886434..886664 (231 bp)
Type: Others
Protein ID: WP_006247802.1
Location: 886709..887110 (402 bp)
Type: Others
Protein ID: WP_006247801.1
Location: 887193..887834 (642 bp)
Type: Others
Protein ID: WP_006247800.1
Location: 887866..888261 (396 bp)
Type: Others
Protein ID: WP_006247799.1
Location: 888286..888513 (228 bp)
Type: Others
Protein ID: Protein_848
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
WC39_RS04425880961..881260+300WP_006247810.1XRE family transcriptional regulator-
WC39_RS14415881269..881427-159WP_006247809.1hypothetical protein-
WC39_RS04430881437..882123-687WP_006247808.1hypothetical protein-
WC39_RS04435882234..882845-612WP_006253310.1hypothetical protein-
WC39_RS04440882894..883520-627WP_006247807.1tail assembly protein-
WC39_RS04450883742..884461-720WP_006247806.1preprotein translocase subunit YajC-
WC39_RS04455884451..884741-291Protein_839C40 family peptidase-
WC39_RS04460884719..885429-711WP_006253312.1tape measure protein-
WC39_RS04465885489..885752-264WP_006247805.1hypothetical protein-
WC39_RS04470885827..886096-270WP_006247804.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
WC39_RS04475886100..886366-267WP_006247803.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
WC39_RS04480886434..886664-231WP_006247802.1DUF4035 domain-containing protein-
WC39_RS04485886709..887110-402WP_006247801.1hypothetical protein-
WC39_RS04490887193..887834-642WP_006247800.1hypothetical protein-
WC39_RS04495887866..888261-396WP_006247799.1phage tail protein-
WC39_RS13855888286..888513-228Protein_848phage terminase large subunit family protein-
WC39_RS04500888663..889037+375WP_006247798.1hypothetical protein-
WC39_RS04505889045..889212+168WP_006253314.1DNA cytosine methyltransferase-
WC39_RS13860889293..889616+324WP_006253316.1helix-turn-helix domain-containing protein-
WC39_RS04510889520..890230+711Protein_852tyrosine-type recombinase/integrase-
WC39_RS04515890331..890966+636Protein_853transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--874773..89897924206
-flankIS/Tn--890331..891023692


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-75)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10278.90 Da        Isoelectric Point: 6.2121

>T53329 WP_006247804.1 NZ_CP011098:c886096-885827 [Mannheimia haemolytica]
MLQISPTNAYKRDFKKIAAELVGSSEYVEVMYCLINQLPLAEKYRDHPLQGEWQGFRDCHIKPDLVLIYAVEDNLLRLVR
LGSHAELFG

Download         Length: 270 bp

>T53329 NZ_CP011098:c886096-885827 [Mannheimia haemolytica]
ATGCTACAAATTTCGCCGACAAACGCATATAAAAGAGACTTTAAAAAGATTGCAGCCGAATTAGTCGGTAGTTCGGAATA
TGTGGAAGTAATGTATTGCCTAATAAACCAATTACCATTGGCGGAAAAATATAGAGATCACCCACTACAAGGTGAATGGC
AAGGCTTTAGAGATTGCCATATTAAGCCTGATTTAGTGTTGATTTACGCTGTTGAAGATAATCTGCTCCGCCTTGTTCGT
TTAGGATCGCACGCTGAATTATTTGGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9913.38 Da        Isoelectric Point: 7.0082

>AT53329 WP_006247803.1 NZ_CP011098:c886366-886100 [Mannheimia haemolytica]
MATINDAFSFRTNTEIKNTAFDVIKNYGMTPSQVFNMFLTEIAKTKTIPLSLNYQPNLETKLAMQEAKSGKNEVYASLEA
FHKAMLAE

Download         Length: 267 bp

>AT53329 NZ_CP011098:c886366-886100 [Mannheimia haemolytica]
ATGGCGACTATCAATGATGCTTTCAGTTTTAGAACAAATACCGAAATAAAAAATACCGCATTTGATGTAATTAAAAACTA
TGGAATGACACCCTCTCAGGTGTTTAATATGTTTTTAACCGAGATTGCAAAAACGAAAACTATTCCGTTAAGTTTGAATT
ATCAACCCAATCTTGAAACAAAATTGGCAATGCAAGAAGCAAAATCAGGTAAAAATGAAGTTTATGCCTCACTTGAAGCA
TTTCATAAAGCAATGTTAGCGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A248ZYA9

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A547E920

References