Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 308688..309277 Replicon chromosome
Accession NZ_CP011098
Organism Mannheimia haemolytica strain 89010807N isolate laboratory frozen stock

Toxin (Protein)


Gene name pemK Uniprot ID A0A248ZY19
Locus tag WC39_RS01575 Protein ID WP_006248516.1
Coordinates 308688..309020 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A248ZX26
Locus tag WC39_RS01580 Protein ID WP_006248517.1
Coordinates 309017..309277 (-) Length 87 a.a.

Genomic Context

WC39_RS01560WC39_RS01565WC39_RS01605WC39_RS01535WC39_RS01540WC39_RS01570WC39_RS01575WC39_RS01580WC39_RS01585WC39_RS01590WC39_RS01595WC39_RS01600
Location: 306128..306655 (528 bp)
Type: Others
Protein ID: WP_006248512.1
Location: 306711..307466 (756 bp)
Type: Others
Protein ID: WP_006248513.1
Location: 312953..314098 (1146 bp)
Type: Others
Protein ID: WP_006248526.1
Location: 303883..304503 (621 bp)
Type: Others
Protein ID: WP_006248508.1
Location: 304514..305548 (1035 bp)
Type: Others
Protein ID: WP_006248509.1
Location: 307530..308561 (1032 bp)
Type: Others
Protein ID: WP_006248514.1
Location: 308688..309020 (333 bp)
Type: Toxin
Protein ID: WP_006248516.1
Location: 309017..309277 (261 bp)
Type: Antitoxin
Protein ID: WP_006248517.1
Location: 309347..310015 (669 bp)
Type: Others
Protein ID: WP_006248518.1
Location: 310102..310899 (798 bp)
Type: Others
Protein ID: WP_006248519.1
Location: 310907..311695 (789 bp)
Type: Others
Protein ID: WP_006248520.1
Location: 311697..312341 (645 bp)
Type: Others
Protein ID: WP_006248521.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
WC39_RS01535303883..304503-621WP_006248508.1dTMP kinase-
WC39_RS01540304514..305548-1035WP_006248509.1endolytic transglycosylase MltG-
WC39_RS01560306128..306655+528WP_006248512.1inorganic diphosphatase-
WC39_RS01565306711..307466+756WP_006248513.1M48 family metallopeptidase-
WC39_RS01570307530..308561-1032WP_006248514.1tryptophan--tRNA ligase-
WC39_RS01575308688..309020-333WP_006248516.1type II toxin-antitoxin system PemK/MazF family toxinToxin
WC39_RS01580309017..309277-261WP_006248517.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
WC39_RS01585309347..310015-669WP_006248518.1phosphoglycolate phosphatase-
WC39_RS01590310102..310899-798WP_006248519.1prolipoprotein diacylglyceryl transferase-
WC39_RS01595310907..311695-789WP_006248520.1sulfite exporter TauE/SafE family protein-
WC39_RS01600311697..312341-645WP_006248521.1RNA pyrophosphohydrolase-
WC39_RS01605312953..314098+1146WP_006248526.1FMN-dependent L-lactate dehydrogenase LldD-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-109)

Antitoxin

SpoVT-AbrB domain

(7-48)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12007.94 Da        Isoelectric Point: 6.4597

>T53326 WP_006248516.1 NZ_CP011098:c309020-308688 [Mannheimia haemolytica]
MKRGDIYWLDLDPTLGHEQSGFRPVVIVSATAFNLASKLPVVVPITNGGAFAERLGFAVSLKDAGLKTTGIIRCDQPRTV
DIAQRHGKFIEALPESLLDEIMARVSVIFE

Download         Length: 333 bp

>T53326 NZ_CP011098:c309020-308688 [Mannheimia haemolytica]
ATGAAACGTGGCGATATTTACTGGCTCGATCTTGATCCAACCTTAGGACACGAACAATCAGGCTTCCGCCCCGTTGTAAT
TGTTTCCGCAACTGCATTTAATCTAGCCAGTAAACTGCCTGTGGTTGTGCCGATTACTAACGGTGGAGCTTTTGCTGAAA
GACTGGGCTTTGCCGTTTCATTAAAAGATGCCGGCTTAAAAACAACAGGGATTATTCGATGCGATCAACCTCGCACAGTC
GATATTGCACAACGCCATGGAAAATTTATCGAAGCCTTACCCGAAAGCCTACTTGATGAAATTATGGCAAGGGTTTCAGT
GATTTTTGAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9418.88 Da        Isoelectric Point: 4.7228

>AT53326 WP_006248517.1 NZ_CP011098:c309277-309017 [Mannheimia haemolytica]
MPTIALRQVGGSVAMVIPPAFLEALKLSVGSKVDLSLNDNQLVINPARPKVKYSLEELLRQSDFEAARNEESQSWLSEPA
IGKEIL

Download         Length: 261 bp

>AT53326 NZ_CP011098:c309277-309017 [Mannheimia haemolytica]
ATGCCAACAATCGCATTACGTCAGGTCGGTGGCTCGGTTGCAATGGTGATTCCGCCTGCTTTTTTAGAGGCACTCAAGCT
CTCCGTCGGTAGCAAAGTGGATTTGTCTTTAAACGACAACCAACTCGTGATTAATCCTGCCCGCCCAAAAGTGAAATACA
GCTTAGAGGAATTATTAAGACAATCCGATTTTGAGGCAGCAAGGAATGAAGAAAGCCAATCGTGGTTATCCGAGCCGGCA
ATAGGAAAAGAAATTTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A248ZY19

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A248ZX26

References