53324

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3248141..3248764 Replicon chromosome
Accession NZ_CP011078
Organism Yersinia ruckeri strain Big Creek 74

Toxin (Protein)


Gene name Hha Uniprot ID A0A085U5C4
Locus tag UGYR_RS14625 Protein ID WP_038243726.1
Coordinates 3248141..3248344 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A085U5C5
Locus tag UGYR_RS14630 Protein ID WP_004718732.1
Coordinates 3248396..3248764 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
UGYR_RS14605 3243996..3244334 + 339 WP_007886947.1 P-II family nitrogen regulator -
UGYR_RS14610 3244373..3245662 + 1290 WP_004718723.1 ammonium transporter AmtB -
UGYR_RS14615 3245777..3246640 - 864 WP_004718726.1 acyl-CoA thioesterase II -
UGYR_RS14620 3247018..3247332 - 315 WP_004718728.1 MGMT family protein -
UGYR_RS14625 3248141..3248344 - 204 WP_038243726.1 expression modulating protein YmoA Toxin
UGYR_RS14630 3248396..3248764 - 369 WP_004718732.1 Hha toxicity modulator TomB Antitoxin
UGYR_RS17545 3249837..3249974 + 138 WP_155274690.1 hypothetical protein -
UGYR_RS17170 3250093..3250236 - 144 WP_004718738.1 type B 50S ribosomal protein L36 -
UGYR_RS14640 3250256..3250510 - 255 WP_038243728.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8037.27 Da        Isoelectric Point: 6.4573

>T53324 WP_038243726.1 NZ_CP011078:c3248344-3248141 [Yersinia ruckeri]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPATVWQHVK

Download         Length: 204 bp

>T53324 NZ_CP011078:c3248344-3248141 [Yersinia ruckeri]
ATGACCAAAACTGACTACCTAATGCGTTTAAGAAAATGCACAACAATTGACACACTAGAGCGTGTTATTGAAAAAAATAA
GTATGAGCTATCTGATGATGAACTAGAATTATTCTATTCTGCTGCGGATCATCGTCTAGCTGAACTTACCATGAATAAGT
TATACGATAAAATTCCTGCAACTGTCTGGCAACATGTGAAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14277.08 Da        Isoelectric Point: 4.4225

>AT53324 WP_004718732.1 NZ_CP011078:c3248764-3248396 [Yersinia ruckeri]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYADEIDLCELVEEYL
DDTYTLFSSYGINDPDLRRWQKTKDRLFRLFSGEYLCALMKN

Download         Length: 369 bp

>AT53324 NZ_CP011078:c3248764-3248396 [Yersinia ruckeri]
ATGGATGAGTACTCACCTAAGCGACATGATATTGCTCAGTTGAAATTCTTATGTGAGAATTTGTATGATGAAGGTATCGC
CACATTGGGCGATAGCCACCACGGCTGGGTTAATGATCCAACCTCCGCGGTAAATCTCCAACTGAATGATTTAATCGAAC
ACATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACGCAGACGAAATCGATCTCTGCGAGTTGGTGGAGGAATATCTA
GACGATACATATACCTTGTTCAGCAGTTACGGAATCAATGATCCTGATTTACGCCGCTGGCAGAAAACAAAAGACCGATT
ATTCAGACTATTTTCAGGGGAATACCTATGTGCCCTGATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085U5C4

Antitoxin

Source ID Structure
AlphaFold DB A0A085U5C5

References