Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4879944..4880560 Replicon chromosome
Accession NZ_CP011077
Organism Klebsiella michiganensis strain RC10

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag VW41_RS22715 Protein ID WP_045784322.1
Coordinates 4879944..4880321 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag VW41_RS22720 Protein ID WP_045784323.1
Coordinates 4880321..4880560 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VW41_RS22690 4875257..4876057 - 801 WP_045784318.1 DeoR/GlpR family DNA-binding transcription regulator -
VW41_RS22695 4876457..4877170 + 714 WP_045784319.1 deoxyribose-phosphate aldolase -
VW41_RS22700 4877218..4878747 + 1530 WP_045784320.1 pentose kinase -
VW41_RS22705 4878803..4879564 + 762 WP_045784321.1 DeoR/GlpR family DNA-binding transcription regulator -
VW41_RS22710 4879617..4879820 - 204 WP_045784750.1 YgdI/YgdR family lipoprotein -
VW41_RS22715 4879944..4880321 - 378 WP_045784322.1 type II toxin-antitoxin system VapC family toxin Toxin
VW41_RS22720 4880321..4880560 - 240 WP_045784323.1 ribbon-helix-helix domain-containing protein Antitoxin
VW41_RS22725 4880848..4881183 + 336 WP_045784324.1 nuclear transport factor 2 family protein -
VW41_RS22730 4881617..4882720 + 1104 WP_045784325.1 DUF262 domain-containing protein -
VW41_RS22735 4882722..4883825 + 1104 WP_045784326.1 DUF3696 domain-containing protein -
VW41_RS22740 4883846..4884697 + 852 WP_148674351.1 hypothetical protein -
VW41_RS22745 4884706..4884897 - 192 WP_045784751.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(15-49)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14273.43 Da        Isoelectric Point: 8.5039

>T53310 WP_045784322.1 NZ_CP011077:c4880321-4879944 [Klebsiella michiganensis]
MEKQSSVFDTNVLIDFLSGRPEAQEMMEKYNVGRSISVVTWMEVLVGVRDSRQEAQTRQFLSHFDVLPVTQSVSERAVEL
RRQYKMKLPDAIILASTHVAQKTLLTRNTKDFKDIPGVIVPYSLS

Download         Length: 378 bp

>T53310 NZ_CP011077:c4880321-4879944 [Klebsiella michiganensis]
ATGGAAAAGCAATCTTCTGTCTTTGATACCAATGTATTAATTGATTTTCTGAGTGGCCGACCTGAGGCTCAAGAAATGAT
GGAGAAGTACAACGTCGGACGTTCAATAAGCGTTGTTACGTGGATGGAGGTGTTGGTTGGGGTGAGGGATAGTCGGCAGG
AAGCCCAGACTCGACAGTTTCTCTCTCATTTTGATGTATTGCCTGTCACTCAATCTGTTTCGGAAAGAGCGGTTGAACTC
AGAAGGCAATATAAGATGAAACTTCCTGACGCGATCATTCTGGCCTCTACTCATGTTGCTCAAAAAACACTGCTTACTCG
TAATACTAAGGACTTTAAAGATATTCCAGGCGTGATTGTGCCTTACTCACTCTCATAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9089.23 Da        Isoelectric Point: 4.3775

>AT53310 WP_045784323.1 NZ_CP011077:c4880560-4880321 [Klebsiella michiganensis]
MATVIGEGMGRILLDLSDEAIRQLDGLKQKRNLPRAELLREAVDQYLARQQSDINDAFGLWGESTPDGLEYERKLREEW

Download         Length: 240 bp

>AT53310 NZ_CP011077:c4880560-4880321 [Klebsiella michiganensis]
ATGGCTACCGTTATTGGAGAAGGTATGGGACGCATTCTTCTGGATCTCTCGGATGAGGCGATCAGACAGCTTGATGGCCT
AAAGCAAAAGCGCAATTTGCCCAGAGCCGAGCTTCTCAGAGAGGCTGTTGATCAATATCTGGCGCGGCAGCAGTCCGATA
TCAATGATGCATTTGGGCTTTGGGGAGAGAGTACCCCCGATGGGCTGGAGTATGAGAGAAAGCTGCGTGAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References