53306

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3641975..3642592 Replicon chromosome
Accession NZ_CP011077
Organism Klebsiella michiganensis strain RC10

Toxin (Protein)


Gene name Hha Uniprot ID S3J5Z6
Locus tag VW41_RS16770 Protein ID WP_008460299.1
Coordinates 3642377..3642592 (+) Length 72 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A1X7LVC3
Locus tag VW41_RS16765 Protein ID WP_008460297.1
Coordinates 3641975..3642349 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VW41_RS16755 3637038..3638237 + 1200 WP_039295998.1 efflux RND transporter periplasmic adaptor subunit -
VW41_RS16760 3638260..3641409 + 3150 WP_045783475.1 multidrug efflux RND transporter permease subunit -
VW41_RS16765 3641975..3642349 + 375 WP_008460297.1 Hha toxicity modulator TomB Antitoxin
VW41_RS16770 3642377..3642592 + 216 WP_008460299.1 hemolysin expression modulator Hha Toxin
VW41_RS16775 3642846..3643397 + 552 WP_045783476.1 maltose O-acetyltransferase -
VW41_RS16780 3643523..3643999 + 477 WP_045783477.1 YlaC family protein -
VW41_RS16785 3644003..3644143 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
VW41_RS16790 3644147..3644407 - 261 WP_045783478.1 type B 50S ribosomal protein L31 -
VW41_RS16795 3644532..3646436 - 1905 WP_045783479.1 methyl-accepting chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(12-68)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 72 a.a.        Molecular weight: 8526.94 Da        Isoelectric Point: 9.4828

>T53306 WP_008460299.1 NZ_CP011077:3642377-3642592 [Klebsiella michiganensis]
MTTKLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPPSVWKFIR

Download         Length: 216 bp

>T53306 NZ_CP011077:3642377-3642592 [Klebsiella michiganensis]
ATGACTACCAAGCTCACCAAGACCGATTATTTGATGCGTCTTCGACGTTGTCAGACAATTGATACGCTGGAACGCGTAAT
AGAAAAAAATAAATATGAATTATCAGATAATGAGCTGGCGGTGTTTTATTCAGCAGCCGATCACCGCCTTGCAGAACTGA
CGATGAATAAACTGTATGACAAAATCCCACCTTCAGTGTGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14459.17 Da        Isoelectric Point: 5.1574

>AT53306 WP_008460297.1 NZ_CP011077:3641975-3642349 [Klebsiella michiganensis]
MDEYSPKRHDIAQLKFLCESLYHDCLTNLGESNHGWVNDPTSAINLQLNELIEHIAASALNYKIKYPDESKLIEQIDEYL
DDTFMLFSNYGINAQDLQRWRKSGNRLFRCFISESRANPVSHSF

Download         Length: 375 bp

>AT53306 NZ_CP011077:3641975-3642349 [Klebsiella michiganensis]
ATGGACGAATACTCACCAAAGCGGCATGATATCGCGCAGCTTAAGTTCCTCTGTGAGAGTCTGTATCACGATTGTCTGAC
CAATCTTGGTGAGAGCAATCATGGATGGGTTAATGATCCTACATCGGCCATTAATCTACAGTTGAATGAATTGATTGAGC
ACATTGCCGCATCTGCGCTTAATTATAAGATTAAGTATCCAGATGAGAGCAAATTGATTGAACAGATTGATGAATACCTG
GACGATACTTTCATGCTATTTAGCAATTACGGCATTAATGCACAAGATTTGCAGCGGTGGCGTAAATCGGGGAATCGCTT
GTTCAGATGTTTCATCAGTGAGAGTCGCGCTAACCCAGTAAGCCACTCGTTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X7LUT2

Antitoxin

Source ID Structure
AlphaFold DB A0A1X7LVC3

References