Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 4261017..4261621 Replicon chromosome
Accession NZ_CP011072
Organism Azoarcus sp. CIB

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag AzCIB_RS19075 Protein ID WP_050417348.1
Coordinates 4261017..4261412 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag AzCIB_RS19080 Protein ID WP_050417349.1
Coordinates 4261412..4261621 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AzCIB_RS19045 4256999..4257391 + 393 WP_050417343.1 diacylglycerol kinase -
AzCIB_RS19050 4257428..4257904 - 477 WP_050417344.1 glycine zipper 2TM domain-containing protein -
AzCIB_RS19055 4257898..4258833 - 936 WP_050417345.1 carbohydrate kinase family protein -
AzCIB_RS19060 4258889..4259299 - 411 WP_050417346.1 HIT family protein -
AzCIB_RS19065 4259418..4260176 + 759 WP_050417347.1 GNAT family N-acetyltransferase -
AzCIB_RS19070 4260272..4261063 + 792 WP_083447074.1 1-acyl-sn-glycerol-3-phosphate acyltransferase -
AzCIB_RS19075 4261017..4261412 - 396 WP_050417348.1 PIN domain nuclease Toxin
AzCIB_RS19080 4261412..4261621 - 210 WP_050417349.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
AzCIB_RS19085 4261692..4262489 - 798 WP_050417350.1 symmetrical bis(5'-nucleosyl)-tetraphosphatase -
AzCIB_RS19090 4262618..4264507 - 1890 WP_050417351.1 polysaccharide biosynthesis protein -
AzCIB_RS19095 4264650..4265684 - 1035 WP_050417352.1 glycosyltransferase family 4 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-121)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-44)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14506.76 Da        Isoelectric Point: 4.2964

>T53297 WP_050417348.1 NZ_CP011072:c4261412-4261017 [Azoarcus sp. CIB]
MLVDTSVWIDFFNGYDSRASMRLADAIAEGESIAVPGIVLTEILLGLRDDAEAARIADLLGAFEEIADPTRADYAEAARI
YRVCRLRGFTIRSTIDCLIAQLCLRDGIPLLTKDRDFKAIAQCLPLQLFEP

Download         Length: 396 bp

>T53297 NZ_CP011072:c4261412-4261017 [Azoarcus sp. CIB]
ATGTTGGTGGATACGTCGGTCTGGATCGACTTCTTCAATGGGTACGACTCCCGTGCGTCAATGCGATTGGCCGATGCCAT
CGCCGAGGGGGAGTCGATCGCTGTTCCGGGCATTGTGCTTACGGAGATTTTGCTCGGGCTCAGGGACGACGCGGAGGCGG
CGCGCATCGCGGATCTGCTGGGCGCATTCGAGGAGATCGCCGATCCCACGAGGGCGGATTACGCCGAGGCCGCGCGGATT
TACCGCGTTTGTCGCCTACGGGGCTTCACCATCCGTTCGACGATAGATTGCCTGATTGCTCAGTTGTGCCTGCGGGATGG
CATTCCTCTGCTCACCAAGGATCGCGATTTCAAGGCAATTGCGCAGTGCCTGCCTCTACAGTTGTTTGAGCCCTGA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7897.11 Da        Isoelectric Point: 11.0968

>AT53297 WP_050417349.1 NZ_CP011072:c4261621-4261412 [Azoarcus sp. CIB]
MRTHVELDDQLLTQVVQLGHFPTKKAAINAALFEFARTLKRRELLALRGKVDWRGNLDDLRSPRAGADR

Download         Length: 210 bp

>AT53297 NZ_CP011072:c4261621-4261412 [Azoarcus sp. CIB]
ATGAGAACTCATGTAGAGCTCGACGATCAGCTTTTGACCCAAGTCGTTCAACTTGGGCATTTCCCGACGAAGAAAGCGGC
GATCAATGCAGCCTTGTTCGAATTCGCAAGAACGCTCAAGCGAAGGGAGTTGCTCGCCTTGCGGGGGAAGGTCGACTGGC
GCGGGAATCTTGACGATTTGCGCTCGCCGCGCGCGGGCGCAGACCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References