Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 2994544..2995142 Replicon chromosome
Accession NZ_CP011072
Organism Azoarcus sp. CIB

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag AzCIB_RS13225 Protein ID WP_050416321.1
Coordinates 2994544..2994834 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag AzCIB_RS13230 Protein ID WP_198149532.1
Coordinates 2994831..2995142 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AzCIB_RS13205 2989742..2990557 + 816 WP_050416317.1 septum site-determining protein MinD -
AzCIB_RS13210 2990559..2990819 + 261 WP_050416318.1 cell division topological specificity factor MinE -
AzCIB_RS13215 2990882..2992681 - 1800 WP_050416319.1 methyl-accepting chemotaxis protein -
AzCIB_RS13220 2992890..2994398 + 1509 WP_050416320.1 lysine--tRNA ligase -
AzCIB_RS13225 2994544..2994834 + 291 WP_050416321.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AzCIB_RS13230 2994831..2995142 + 312 WP_198149532.1 putative addiction module antidote protein Antitoxin
AzCIB_RS13235 2995209..2997116 + 1908 WP_050416323.1 bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC -
AzCIB_RS13240 2997592..2999142 + 1551 WP_050416324.1 PAS domain-containing protein -
AzCIB_RS13245 2999139..2999795 + 657 WP_050416325.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-91)

Antitoxin

Uncharacterized protein HI1420

(6-96)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10944.54 Da        Isoelectric Point: 10.7653

>T53296 WP_050416321.1 NZ_CP011072:2994544-2994834 [Azoarcus sp. CIB]
MYLIRQTETFVEWLRNLRDTRAKARIAARLRMAGEGNLGDNKSVSNGVSEMRIDVGPGYRLYYTRRGDVVIVLLVGGDKS
SQARDIERARRMAQEV

Download         Length: 291 bp

>T53296 NZ_CP011072:2994544-2994834 [Azoarcus sp. CIB]
ATGTACCTGATCCGCCAGACCGAGACCTTCGTCGAATGGCTGCGCAATCTGCGCGACACGCGCGCCAAGGCACGCATCGC
CGCCCGACTGCGCATGGCCGGCGAAGGCAACCTGGGTGACAACAAGAGTGTCAGCAACGGCGTCTCCGAGATGCGGATCG
ACGTGGGACCAGGCTACCGGCTCTACTACACCCGGCGGGGCGACGTCGTCATCGTGCTCTTGGTCGGTGGCGACAAGTCT
TCGCAGGCACGCGACATCGAGCGAGCCCGAAGGATGGCGCAGGAGGTATGA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11186.77 Da        Isoelectric Point: 4.6672

>AT53296 WP_198149532.1 NZ_CP011072:2994831-2995142 [Azoarcus sp. CIB]
MNMTERLIDFDAADYLDSDEAIAEYLTAILEQDDGDLTLKALGDIAKARGMAEISRATGLGRESLYKAFRPGAHPRFDTV
MKVMKALGVKMTAVPVEHGSQPG

Download         Length: 312 bp

>AT53296 NZ_CP011072:2994831-2995142 [Azoarcus sp. CIB]
ATGAACATGACCGAACGACTGATCGACTTCGACGCGGCCGACTACCTCGACAGTGACGAGGCCATCGCGGAGTACCTGAC
TGCGATCCTCGAACAGGACGATGGCGATCTGACCCTGAAGGCGCTGGGGGATATCGCCAAGGCGCGCGGCATGGCGGAGA
TTTCCCGCGCAACCGGCCTCGGGCGCGAAAGTCTCTACAAAGCCTTCCGGCCCGGCGCCCATCCTCGCTTCGACACAGTG
ATGAAGGTGATGAAGGCTCTTGGCGTGAAGATGACCGCCGTTCCGGTCGAACATGGGTCGCAGCCCGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References