Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 1581358..1581902 Replicon chromosome
Accession NZ_CP011072
Organism Azoarcus sp. CIB

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag AzCIB_RS06925 Protein ID WP_050415219.1
Coordinates 1581627..1581902 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag AzCIB_RS06920 Protein ID WP_050415218.1
Coordinates 1581358..1581627 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AzCIB_RS06895 1577954..1578271 + 318 WP_050415214.1 hypothetical protein -
AzCIB_RS06900 1578502..1579269 + 768 WP_050415215.1 hypothetical protein -
AzCIB_RS24095 1579394..1579567 + 174 WP_157058441.1 hypothetical protein -
AzCIB_RS06905 1579589..1580179 - 591 WP_050415216.1 hypothetical protein -
AzCIB_RS24405 1580578..1580895 - 318 Protein_1384 ATP-binding protein -
AzCIB_RS23660 1580910..1581089 + 180 Protein_1385 ATP-binding protein -
AzCIB_RS06920 1581358..1581627 + 270 WP_050415218.1 ribbon-helix-helix domain-containing protein Antitoxin
AzCIB_RS06925 1581627..1581902 + 276 WP_050415219.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AzCIB_RS06930 1582768..1583613 + 846 WP_157058442.1 hypothetical protein -
AzCIB_RS06935 1583655..1584722 + 1068 Protein_1389 IS5 family transposase -
AzCIB_RS24105 1584678..1585097 - 420 WP_157058443.1 transposase -
AzCIB_RS06940 1585293..1585541 - 249 WP_050415221.1 helix-turn-helix domain-containing protein -
AzCIB_RS06945 1585962..1586255 + 294 WP_050415222.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1580722..1651916 71194
- inside IScluster/Tn - - 1580722..1584541 3819


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-46)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10739.47 Da        Isoelectric Point: 8.4941

>T53295 WP_050415219.1 NZ_CP011072:1581627-1581902 [Azoarcus sp. CIB]
MELKWTGKALSDLARLYEFLAPVNKPAAARTIQALTAAPLSLLLNPRIGERLDEFEPREVRRILVGHYEMRYEIQESTIY
MLRLWHTREDR

Download         Length: 276 bp

>T53295 NZ_CP011072:1581627-1581902 [Azoarcus sp. CIB]
ATGGAACTGAAGTGGACCGGCAAGGCGCTCTCCGACTTGGCGCGTCTGTACGAATTTCTCGCCCCGGTAAATAAGCCTGC
CGCTGCGCGCACGATACAGGCGCTCACGGCTGCGCCATTAAGTTTGCTGCTGAACCCACGTATCGGCGAACGGCTCGATG
AATTTGAGCCGCGCGAGGTGCGGCGGATTCTCGTGGGGCATTACGAGATGCGCTATGAGATTCAGGAATCGACGATCTAC
ATGCTGAGGCTGTGGCACACCCGAGAGGATCGCTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9961.33 Da        Isoelectric Point: 5.1007

>AT53295 WP_050415218.1 NZ_CP011072:1581358-1581627 [Azoarcus sp. CIB]
MAPTETKVLTAHIPLPLAEKVDQMAARLERSRGWIMKQALSAWIDQEEERSRLTREALADVDAGRVIDHQAVQAWADSLG
TDTPFPVPR

Download         Length: 270 bp

>AT53295 NZ_CP011072:1581358-1581627 [Azoarcus sp. CIB]
ATGGCACCGACCGAAACCAAAGTGCTGACCGCACATATCCCCCTTCCGTTGGCGGAAAAAGTCGATCAGATGGCTGCCCG
ACTTGAACGATCGCGCGGCTGGATCATGAAGCAGGCGCTGTCGGCCTGGATCGACCAAGAGGAAGAGCGCAGCCGCCTGA
CCCGCGAGGCGCTTGCCGACGTGGACGCCGGTCGGGTCATTGACCATCAGGCTGTGCAGGCATGGGCCGACAGTCTCGGC
ACCGATACACCATTCCCGGTGCCGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References