Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1898959..1899445 Replicon chromosome
Accession NZ_CP011068
Organism Streptococcus pyogenes strain STAB10015

Toxin (Protein)


Gene name relE Uniprot ID Q48QR0
Locus tag VU19_RS09330 Protein ID WP_014407961.1
Coordinates 1898959..1899228 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A660A1J7
Locus tag VU19_RS09335 Protein ID WP_014407962.1
Coordinates 1899218..1899445 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VU19_RS09315 1894454..1895527 + 1074 WP_011285298.1 DUF4097 family beta strand repeat protein -
VU19_RS09320 1895644..1897917 - 2274 WP_021340697.1 YhgE/Pip domain-containing protein -
VU19_RS09325 1898052..1898585 + 534 WP_010922785.1 TetR/AcrR family transcriptional regulator -
VU19_RS09330 1898959..1899228 - 270 WP_014407961.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
VU19_RS09335 1899218..1899445 - 228 WP_014407962.1 hypothetical protein Antitoxin
VU19_RS09340 1899598..1899969 - 372 WP_011285302.1 DUF1492 domain-containing protein -
VU19_RS09345 1899959..1900306 - 348 WP_011285303.1 DUF1492 domain-containing protein -
VU19_RS09350 1900587..1900832 - 246 WP_011285304.1 hypothetical protein -
VU19_RS09355 1900807..1901082 - 276 WP_014407964.1 hypothetical protein -
VU19_RS09360 1901072..1901410 - 339 WP_030126557.1 replication protein -
VU19_RS09365 1901452..1901718 - 267 WP_011285307.1 hypothetical protein -
VU19_RS09370 1901715..1902503 - 789 WP_011285308.1 hypothetical protein -
VU19_RS10550 1902594..1902752 - 159 WP_011285309.1 hypothetical protein -
VU19_RS09380 1902766..1903011 - 246 WP_011285310.1 hypothetical protein -
VU19_RS09385 1903007..1903333 - 327 Protein_1806 hypothetical protein -
VU19_RS10555 1903335..1903508 - 174 WP_011285312.1 hypothetical protein -
VU19_RS10165 1903514..1903687 - 174 WP_000694580.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10497.50 Da        Isoelectric Point: 10.5027

>T53292 WP_014407961.1 NZ_CP011068:c1899228-1898959 [Streptococcus pyogenes]
MTYKLVVSDEVKKQLKKMDKHVGLMLAKDMKKRLDGLNNPRQFGKALTGQYKGLWRYRVGNYRVICDIVDNEMIILALEV
GHRKEIYKR

Download         Length: 270 bp

>T53292 NZ_CP011068:c1899228-1898959 [Streptococcus pyogenes]
ATGACTTATAAGCTAGTGGTGAGTGATGAAGTCAAGAAGCAACTCAAAAAGATGGATAAACATGTAGGGCTTATGTTAGC
CAAAGACATGAAGAAACGACTTGACGGGTTAAATAATCCTAGACAATTTGGAAAAGCCCTCACAGGTCAATATAAAGGAC
TTTGGCGCTATCGTGTTGGTAATTATCGGGTGATTTGTGACATTGTGGATAATGAAATGATTATCCTTGCTTTGGAAGTT
GGACACAGGAAAGAGATATACAAGCGCTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8641.63 Da        Isoelectric Point: 3.9607

>AT53292 WP_014407962.1 NZ_CP011068:c1899445-1899218 [Streptococcus pyogenes]
MAMVSLRLNSAEEELFRSYATHTGKTLSELFKTALAQQIEDQLDYETGIQALKRFEENPITYSIDDLIEELENDL

Download         Length: 228 bp

>AT53292 NZ_CP011068:c1899445-1899218 [Streptococcus pyogenes]
ATGGCAATGGTATCATTAAGACTGAACAGCGCAGAGGAAGAACTTTTCAGAAGCTACGCTACACACACAGGCAAAACATT
ATCTGAATTATTCAAGACAGCACTAGCACAACAAATTGAAGATCAATTGGACTATGAAACAGGTATTCAAGCTTTAAAAC
GCTTTGAAGAAAATCCCATAACTTATTCTATCGATGATTTAATTGAGGAGTTGGAAAATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A660A202

Antitoxin

Source ID Structure
AlphaFold DB A0A660A1J7

References