Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 2567..3114 Replicon plasmid pSJ_82
Accession NZ_CP011065
Organism Escherichia coli str. Sanji

Toxin (Protein)


Gene name parE Uniprot ID A0A4Y1YQH8
Locus tag Y979_RS26640 Protein ID WP_012881118.1
Coordinates 2833..3114 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E2GHF7
Locus tag Y979_RS26635 Protein ID WP_012881119.1
Coordinates 2567..2836 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Y979_RS26620 237..491 + 255 WP_000083830.1 replication regulatory protein RepA -
Y979_RS29445 729..803 + 75 WP_001365705.1 RepA leader peptide Tap -
Y979_RS26625 796..1653 + 858 WP_000130646.1 incFII family plasmid replication initiator RepA -
Y979_RS26635 2567..2836 + 270 WP_012881119.1 ABC transporter ATPase Antitoxin
Y979_RS26640 2833..3114 + 282 WP_012881118.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Y979_RS26645 3160..4008 + 849 WP_012881117.1 3'-5' exonuclease -
Y979_RS26650 4125..4607 + 483 WP_001311056.1 hypothetical protein -
Y979_RS26655 4636..6120 - 1485 WP_016240487.1 IS5 family transposase -
Y979_RS26660 6200..7075 - 876 WP_001617865.1 class A extended-spectrum beta-lactamase CTX-M-14 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaCTX-M-14 - 1..82288 82288
- flank IS/Tn blaCTX-M-14 - 6200..8587 2387


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10875.53 Da        Isoelectric Point: 8.4615

>T53291 WP_012881118.1 NZ_CP011065:2833-3114 [Escherichia coli str. Sanji]
MMEIFWTILASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YILRVLHTAQKWP

Download         Length: 282 bp

>T53291 NZ_CP011065:2833-3114 [Escherichia coli str. Sanji]
ATGATGGAGATATTCTGGACCATACTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTATATTGCGGAGCAGAACCTGAT
GGCTGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTC
GTGTGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTG
TATATCCTGCGAGTATTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10206.54 Da        Isoelectric Point: 8.8735

>AT53291 WP_012881119.1 NZ_CP011065:2567-2836 [Escherichia coli str. Sanji]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLERGDVLPHDMVESSATAWRD
EISRKVAGK

Download         Length: 270 bp

>AT53291 NZ_CP011065:2567-2836 [Escherichia coli str. Sanji]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATTCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACTTGGTTCCGTGACCAGGTTG
CGGCAGGACGTCAGCAACTCGAACGCGGCGATGTGCTTCCCCATGATATGGTCGAATCCTCCGCTACTGCATGGCGGGAT
GAAATAAGCAGGAAGGTCGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y1YQH8

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y1YSD8

References