Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
Location | 759076..759702 | Replicon | chromosome |
Accession | NZ_CP011058 | ||
Organism | Paenibacillus beijingensis strain DSM 24997 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | A0A0D5NF49 |
Locus tag | VN24_RS03610 | Protein ID | WP_045669301.1 |
Coordinates | 759076..759426 (-) | Length | 117 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | - |
Locus tag | VN24_RS03615 | Protein ID | WP_193790123.1 |
Coordinates | 759430..759702 (-) | Length | 91 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
VN24_RS03585 | 755136..755525 | - | 390 | WP_045669297.1 | DUF350 domain-containing protein | - |
VN24_RS03590 | 755522..756250 | - | 729 | WP_045669298.1 | hypothetical protein | - |
VN24_RS03595 | 756251..757447 | - | 1197 | WP_045669299.1 | glutathionylspermidine synthase family protein | - |
VN24_RS03600 | 757444..758217 | - | 774 | WP_045669300.1 | hypothetical protein | - |
VN24_RS03605 | 758245..758469 | - | 225 | WP_052702765.1 | hypothetical protein | - |
VN24_RS03610 | 759076..759426 | - | 351 | WP_045669301.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
VN24_RS03615 | 759430..759702 | - | 273 | WP_193790123.1 | CopG family ribbon-helix-helix protein | Antitoxin |
VN24_RS03620 | 759911..761098 | - | 1188 | WP_148505336.1 | alanine racemase | - |
VN24_RS03625 | 761378..762802 | - | 1425 | WP_045669302.1 | DUF4367 domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12735.60 Da Isoelectric Point: 4.8265
>T53257 WP_045669301.1 NZ_CP011058:c759426-759076 [Paenibacillus beijingensis]
MIVKRGDVFFADLSPVVGSEQGGVRPVLVLQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAAAHGFDRDSVILLEQI
RTIDKQRLTDKITHLDDETMRSVDDALQISVGLIDF
MIVKRGDVFFADLSPVVGSEQGGVRPVLVLQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAAAHGFDRDSVILLEQI
RTIDKQRLTDKITHLDDETMRSVDDALQISVGLIDF
Download Length: 351 bp
>T53257 NZ_CP011058:c759426-759076 [Paenibacillus beijingensis]
TTGATCGTAAAACGCGGCGATGTGTTTTTCGCGGACTTGTCTCCGGTAGTAGGTTCGGAGCAGGGAGGCGTCCGTCCGGT
TCTCGTTCTGCAAAACGACATCGGCAACCGTTTCAGCCCGACGGTTATAGTGGCAGCCATTACCGCCCAGATTCAAAAAG
CAAAGCTGCCGACTCATGTCGAGATCGACGCGGCTGCCCATGGTTTTGATCGTGATTCGGTCATTCTGCTCGAGCAAATA
CGGACCATAGACAAGCAGCGCCTAACAGACAAAATTACTCATTTGGACGACGAAACGATGCGAAGCGTCGACGATGCGCT
GCAAATCAGCGTCGGACTGATCGATTTTTAA
TTGATCGTAAAACGCGGCGATGTGTTTTTCGCGGACTTGTCTCCGGTAGTAGGTTCGGAGCAGGGAGGCGTCCGTCCGGT
TCTCGTTCTGCAAAACGACATCGGCAACCGTTTCAGCCCGACGGTTATAGTGGCAGCCATTACCGCCCAGATTCAAAAAG
CAAAGCTGCCGACTCATGTCGAGATCGACGCGGCTGCCCATGGTTTTGATCGTGATTCGGTCATTCTGCTCGAGCAAATA
CGGACCATAGACAAGCAGCGCCTAACAGACAAAATTACTCATTTGGACGACGAAACGATGCGAAGCGTCGACGATGCGCT
GCAAATCAGCGTCGGACTGATCGATTTTTAA
Antitoxin
Download Length: 91 a.a. Molecular weight: 10454.17 Da Isoelectric Point: 10.0415
>AT53257 WP_193790123.1 NZ_CP011058:c759702-759430 [Paenibacillus beijingensis]
MQNTKRIMISLPDHLLKEVDGIVAKENSNRSEFIRQAMKLYLVERKKRHIRELMQRGYLEMAKINLNMASEAFHAEEDAD
RALGRLVSGV
MQNTKRIMISLPDHLLKEVDGIVAKENSNRSEFIRQAMKLYLVERKKRHIRELMQRGYLEMAKINLNMASEAFHAEEDAD
RALGRLVSGV
Download Length: 273 bp
>AT53257 NZ_CP011058:c759702-759430 [Paenibacillus beijingensis]
ATGCAGAATACCAAAAGAATCATGATCAGTTTACCGGACCATTTATTGAAAGAAGTGGACGGCATTGTCGCCAAGGAGAA
CTCGAACCGAAGTGAATTTATACGCCAGGCGATGAAACTGTATCTTGTTGAGCGCAAAAAAAGACATATTCGGGAATTAA
TGCAGCGCGGGTATCTGGAAATGGCAAAAATCAACTTGAATATGGCCTCGGAAGCTTTTCATGCGGAGGAAGATGCCGAC
CGTGCGCTCGGCCGTCTCGTTAGCGGGGTGTAG
ATGCAGAATACCAAAAGAATCATGATCAGTTTACCGGACCATTTATTGAAAGAAGTGGACGGCATTGTCGCCAAGGAGAA
CTCGAACCGAAGTGAATTTATACGCCAGGCGATGAAACTGTATCTTGTTGAGCGCAAAAAAAGACATATTCGGGAATTAA
TGCAGCGCGGGTATCTGGAAATGGCAAAAATCAACTTGAATATGGCCTCGGAAGCTTTTCATGCGGAGGAAGATGCCGAC
CGTGCGCTCGGCCGTCTCGTTAGCGGGGTGTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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