Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/PIN-AbrB |
| Location | 2595040..2595688 | Replicon | chromosome |
| Accession | NZ_CP011057 | ||
| Organism | Saccharolobus solfataricus strain SULA isolate 98/2 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | Q97WZ2 |
| Locus tag | SULA_RS14150 | Protein ID | WP_009991912.1 |
| Coordinates | 2595040..2595426 (-) | Length | 129 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | Q97WZ1 |
| Locus tag | SULA_RS14155 | Protein ID | WP_009991915.1 |
| Coordinates | 2595413..2595688 (-) | Length | 92 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SULA_RS14120 (SULA_2787) | 2590122..2590895 | - | 774 | WP_009991748.1 | extradiol dioxygenase | - |
| SULA_RS14125 (SULA_2788) | 2591151..2591576 | - | 426 | WP_009991747.1 | DUF4143 domain-containing protein | - |
| SULA_RS14130 (SULA_2789) | 2591863..2592219 | + | 357 | Protein_2797 | IS607 family transposase | - |
| SULA_RS14135 (SULA_2790) | 2592295..2593245 | - | 951 | WP_010923701.1 | IS110 family transposase | - |
| SULA_RS14140 (SULA_2791) | 2593404..2593688 | + | 285 | Protein_2799 | IS607-like element ISC1913 family transposase | - |
| SULA_RS14145 (SULA_2792) | 2593672..2594892 | + | 1221 | WP_014511730.1 | IS200/IS605 family accessory protein TnpB-related protein | - |
| SULA_RS14150 (SULA_2793) | 2595040..2595426 | - | 387 | WP_009991912.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| SULA_RS14155 (SULA_2794) | 2595413..2595688 | - | 276 | WP_009991915.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
| SULA_RS14160 (SULA_2795) | 2596059..2596295 | + | 237 | WP_009991916.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| SULA_RS14165 (SULA_2796) | 2596273..2596671 | + | 399 | WP_009991918.1 | type II toxin-antitoxin system VapC family toxin | - |
| SULA_RS14170 (SULA_2797) | 2597060..2597284 | + | 225 | WP_009991920.1 | type II toxin-antitoxin system CcdA family antitoxin | - |
| SULA_RS14175 (SULA_2798) | 2597274..2597666 | + | 393 | WP_009991922.1 | type II toxin-antitoxin system VapC family toxin | - |
| SULA_RS14180 (SULA_2799) | 2597842..2598792 | + | 951 | WP_052885475.1 | IS110 family transposase | - |
| SULA_RS14185 (SULA_2800) | 2598866..2599915 | - | 1050 | Protein_2808 | AMP-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | IScluster/Tn | - | - | 2591863..2598792 | 6929 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 129 a.a. Molecular weight: 15042.69 Da Isoelectric Point: 4.9844
>T53255 WP_009991912.1 NZ_CP011057:c2595426-2595040 [Saccharolobus solfataricus]
MIFLDANFLIYLNSGVSEVKEYYIKLLTYESLFSDPLVIDEVIYVSKKKYGVKYCDTIEFLDEIVLKYLTVLPITIKEYE
RAKEIMRKYSVKPSDAFHIAVMLNNSINVILSEDKELDKVAEIKRIWI
MIFLDANFLIYLNSGVSEVKEYYIKLLTYESLFSDPLVIDEVIYVSKKKYGVKYCDTIEFLDEIVLKYLTVLPITIKEYE
RAKEIMRKYSVKPSDAFHIAVMLNNSINVILSEDKELDKVAEIKRIWI
Download Length: 387 bp
>T53255 NZ_CP011057:c2595426-2595040 [Saccharolobus solfataricus]
TTGATTTTTCTTGATGCTAATTTCTTAATCTACTTAAACTCGGGTGTAAGTGAGGTAAAAGAGTATTATATAAAACTCCT
CACATATGAAAGCTTGTTTTCAGATCCTTTAGTTATAGATGAGGTAATATACGTGTCTAAGAAGAAGTATGGAGTTAAGT
ATTGCGATACCATAGAATTCTTGGATGAAATAGTGCTCAAGTACTTAACAGTTTTACCAATCACGATAAAGGAATATGAG
AGGGCTAAAGAAATTATGAGAAAATACTCAGTTAAGCCATCTGATGCCTTTCATATTGCCGTAATGTTAAACAATTCAAT
AAACGTGATCTTAAGTGAAGATAAGGAGTTAGATAAAGTTGCAGAAATAAAGAGAATATGGATTTAA
TTGATTTTTCTTGATGCTAATTTCTTAATCTACTTAAACTCGGGTGTAAGTGAGGTAAAAGAGTATTATATAAAACTCCT
CACATATGAAAGCTTGTTTTCAGATCCTTTAGTTATAGATGAGGTAATATACGTGTCTAAGAAGAAGTATGGAGTTAAGT
ATTGCGATACCATAGAATTCTTGGATGAAATAGTGCTCAAGTACTTAACAGTTTTACCAATCACGATAAAGGAATATGAG
AGGGCTAAAGAAATTATGAGAAAATACTCAGTTAAGCCATCTGATGCCTTTCATATTGCCGTAATGTTAAACAATTCAAT
AAACGTGATCTTAAGTGAAGATAAGGAGTTAGATAAAGTTGCAGAAATAAAGAGAATATGGATTTAA
Antitoxin
Download Length: 92 a.a. Molecular weight: 10372.22 Da Isoelectric Point: 7.0185
>AT53255 WP_009991915.1 NZ_CP011057:c2595688-2595413 [Saccharolobus solfataricus]
MSLTLRVEVGKKGYIIIPKSVRDLVGIKEGDILILTVVGDKIILEPERKVNIREVVKKLEEHERKISYAKRASLGELENI
SLEEELKIDFS
MSLTLRVEVGKKGYIIIPKSVRDLVGIKEGDILILTVVGDKIILEPERKVNIREVVKKLEEHERKISYAKRASLGELENI
SLEEELKIDFS
Download Length: 276 bp
>AT53255 NZ_CP011057:c2595688-2595413 [Saccharolobus solfataricus]
ATGAGTTTGACTCTAAGAGTGGAAGTTGGAAAGAAGGGTTATATAATAATTCCTAAAAGTGTAAGGGATTTGGTGGGAAT
AAAAGAGGGGGATATCTTAATTTTGACAGTCGTTGGAGATAAGATAATCTTAGAACCTGAGAGGAAGGTTAACATACGAG
AAGTTGTCAAAAAATTAGAAGAACATGAGAGGAAGATATCTTATGCTAAAAGGGCAAGCCTTGGGGAACTTGAGAACATA
AGTCTTGAAGAGGAATTGAAGATTGATTTTTCTTGA
ATGAGTTTGACTCTAAGAGTGGAAGTTGGAAAGAAGGGTTATATAATAATTCCTAAAAGTGTAAGGGATTTGGTGGGAAT
AAAAGAGGGGGATATCTTAATTTTGACAGTCGTTGGAGATAAGATAATCTTAGAACCTGAGAGGAAGGTTAACATACGAG
AAGTTGTCAAAAAATTAGAAGAACATGAGAGGAAGATATCTTATGCTAAAAGGGCAAGCCTTGGGGAACTTGAGAACATA
AGTCTTGAAGAGGAATTGAAGATTGATTTTTCTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E3KDP7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E3MDU1 |