Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/HTH_10(toxin)
Location 2458286..2459265 Replicon chromosome
Accession NZ_CP011057
Organism Saccharolobus solfataricus strain SULA isolate 98/2

Toxin (Protein)


Gene name vapC Uniprot ID Q97X87
Locus tag SULA_RS13360 Protein ID WP_009988462.1
Coordinates 2458286..2458900 (-) Length 205 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q97X88
Locus tag SULA_RS13365 Protein ID WP_009988464.1
Coordinates 2458918..2459265 (-) Length 116 a.a.

Genomic Context

SULA_RS13335SULA_RS13355SULA_RS13375SULA_RS13385SULA_RS13330SULA_RS13340SULA_RS13345SULA_RS13350SULA_RS13360SULA_RS13365SULA_RS13370SULA_RS13380SULA_RS13390SULA_RS13395
Location: 2455628..2455870 (243 bp)
Type: Others
Protein ID: WP_009988456.1
Location: 2457721..2457996 (276 bp)
Type: Others
Protein ID: WP_009988461.1
Location: 2459658..2460047 (390 bp)
Type: Others
Protein ID: WP_009988467.1
Location: 2460734..2461693 (960 bp)
Type: Others
Protein ID: WP_010923364.1
Location: 2454302..2454901 (600 bp)
Type: Others
Protein ID: WP_009991466.1
Location: 2455851..2456195 (345 bp)
Type: Others
Protein ID: WP_009988458.1
Location: 2456199..2456963 (765 bp)
Type: Others
Protein ID: WP_009988459.1
Location: 2457069..2457599 (531 bp)
Type: Others
Protein ID: WP_009988460.1
Location: 2458286..2458900 (615 bp)
Type: Toxin
Protein ID: WP_009988462.1
Location: 2458918..2459265 (348 bp)
Type: Antitoxin
Protein ID: WP_009988464.1
Location: 2459335..2459565 (231 bp)
Type: Others
Protein ID: WP_009988466.1
Location: 2460040..2460471 (432 bp)
Type: Others
Protein ID: WP_009988468.1
Location: 2462130..2463062 (933 bp)
Type: Others
Protein ID: WP_009988516.1
Location: 2463007..2464203 (1197 bp)
Type: Others
Protein ID: WP_009988517.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
SULA_RS13330 (SULA_2628)2454302..2454901-600WP_009991466.1DUF2249 domain-containing protein-
SULA_RS13335 (SULA_2629)2455628..2455870+243WP_009988456.1hypothetical protein-
SULA_RS13340 (SULA_2630)2455851..2456195-345WP_009988458.1hypothetical protein-
SULA_RS13345 (SULA_2631)2456199..2456963-765WP_009988459.1plastocyanin/azurin family copper-binding protein-
SULA_RS13350 (SULA_2632)2457069..2457599-531WP_009988460.1hemerythrin domain-containing protein-
SULA_RS13355 (SULA_2633)2457721..2457996+276WP_009988461.1hypothetical protein-
SULA_RS13360 (SULA_2634)2458286..2458900-615WP_009988462.1helix-turn-helix domain-containing proteinToxin
SULA_RS13365 (SULA_2635)2458918..2459265-348WP_009988464.1DUF488 domain-containing proteinAntitoxin
SULA_RS13370 (SULA_2636)2459335..2459565-231WP_009988466.1C2H2-type zinc finger protein-
SULA_RS13375 (SULA_2637)2459658..2460047+390WP_009988467.1metal-sulfur cluster assembly factor-
SULA_RS13380 (SULA_2638)2460040..2460471-432WP_009988468.1universal stress protein-
SULA_RS13385 (SULA_2639)2460734..2461693+960WP_010923364.1IS5-like element ISC1234 family transposase-
SULA_RS13390 (SULA_2640)2462130..2463062-933WP_009988516.1dipeptidase-
SULA_RS13395 (SULA_2641)2463007..2464203-1197WP_009988517.1MFS transporter-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-flankIS/Tn--2460734..2461693959


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Bacterioopsin activator-type, HTH domain

(145-197)

Antitoxin

Protein of unknown function DUF488

(3-108)


Sequences

Toxin        


Download         Length: 205 a.a.        Molecular weight: 23424.52 Da        Isoelectric Point: 8.6438

>T53254 WP_009988462.1 NZ_CP011057:c2458900-2458286 [Saccharolobus solfataricus]
MLKSPFEATILIEEHPCEVMKIISSTGLKGVVDNVKLGDNTTDHIVLFEKEVQKDDLIKLKSHSTKVLRLNDNKIWVRTY
GCAVCKILYTSNVVVEKIKVVRERTLLYTLLIPNTMALKEFLASLISQDIEFTVLSTSEISSNELTDRQMEILKLAYKMG
YFDDDRRVTLTELAKQLGISTPTLEEILRRALRKVVKFYLDKVR

Download         Length: 615 bp

>T53254 NZ_CP011057:c2458900-2458286 [Saccharolobus solfataricus]
ATGTTAAAATCACCATTTGAAGCAACAATCCTAATTGAGGAGCACCCTTGTGAAGTAATGAAGATAATATCTAGTACTGG
GCTTAAAGGTGTTGTTGATAACGTTAAACTTGGAGATAATACAACCGATCACATAGTACTTTTCGAAAAAGAGGTCCAAA
AAGATGATCTAATTAAGCTTAAATCGCATAGTACTAAGGTTTTAAGGCTTAACGATAACAAGATATGGGTTAGAACTTAC
GGATGTGCAGTATGTAAGATTCTATATACTTCAAACGTCGTTGTAGAGAAAATAAAGGTAGTAAGAGAGAGGACATTGCT
CTATACTCTCTTAATCCCTAATACGATGGCACTTAAGGAATTTCTGGCAAGCCTCATAAGTCAAGATATAGAGTTTACAG
TGCTAAGCACTTCTGAAATAAGTAGTAATGAGTTAACTGATAGACAAATGGAAATATTGAAGCTTGCGTATAAGATGGGT
TATTTCGATGACGATAGGAGGGTTACTTTAACTGAGCTAGCAAAACAATTGGGAATTTCTACACCAACTTTAGAGGAGAT
TTTGCGTAGGGCTTTAAGGAAAGTTGTCAAGTTTTACTTAGATAAGGTAAGATAG

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13662.96 Da        Isoelectric Point: 9.9061

>AT53254 WP_009988464.1 NZ_CP011057:c2459265-2458918 [Saccharolobus solfataricus]
MIKLKRVYDPIERDDGIRILVDRLWPRGIGKDKVDLWLKDIAPSDELRKWFSHDTSKWDEFKKKYFEELDANPKISVLLQ
LIKKGENITLLYASKSPYNNAVALKEYLEKKILKQ

Download         Length: 348 bp

>AT53254 NZ_CP011057:c2459265-2458918 [Saccharolobus solfataricus]
ATGATTAAATTAAAGAGAGTTTACGATCCAATAGAAAGGGATGATGGAATAAGGATCTTAGTGGATAGGTTATGGCCAAG
AGGTATTGGCAAGGATAAAGTCGATTTGTGGCTCAAAGACATAGCGCCTAGTGATGAATTACGAAAGTGGTTTAGTCACG
ATACTAGTAAATGGGACGAGTTCAAAAAGAAATATTTTGAAGAATTAGATGCTAATCCAAAGATAAGCGTACTATTACAA
TTAATTAAAAAAGGTGAAAATATTACTTTACTTTACGCTTCAAAGTCACCGTATAATAATGCAGTAGCGTTAAAGGAGTA
TCTAGAAAAAAAGATATTAAAACAATAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0E3MDP8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0E3GU05

References