53254

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/HTH_10(toxin)
Location 2458286..2459265 Replicon chromosome
Accession NZ_CP011057
Organism Saccharolobus solfataricus strain SULA isolate 98/2

Toxin (Protein)


Gene name vapC Uniprot ID Q97X87
Locus tag SULA_RS13360 Protein ID WP_009988462.1
Coordinates 2458286..2458900 (-) Length 205 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q97X88
Locus tag SULA_RS13365 Protein ID WP_009988464.1
Coordinates 2458918..2459265 (-) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SULA_RS13330 (SULA_2628) 2454302..2454901 - 600 WP_009991466.1 DUF2249 domain-containing protein -
SULA_RS13335 (SULA_2629) 2455628..2455870 + 243 WP_009988456.1 hypothetical protein -
SULA_RS13340 (SULA_2630) 2455851..2456195 - 345 WP_009988458.1 hypothetical protein -
SULA_RS13345 (SULA_2631) 2456199..2456963 - 765 WP_009988459.1 plastocyanin/azurin family copper-binding protein -
SULA_RS13350 (SULA_2632) 2457069..2457599 - 531 WP_009988460.1 hemerythrin domain-containing protein -
SULA_RS13355 (SULA_2633) 2457721..2457996 + 276 WP_009988461.1 hypothetical protein -
SULA_RS13360 (SULA_2634) 2458286..2458900 - 615 WP_009988462.1 helix-turn-helix domain-containing protein Toxin
SULA_RS13365 (SULA_2635) 2458918..2459265 - 348 WP_009988464.1 DUF488 domain-containing protein Antitoxin
SULA_RS13370 (SULA_2636) 2459335..2459565 - 231 WP_009988466.1 C2H2-type zinc finger protein -
SULA_RS13375 (SULA_2637) 2459658..2460047 + 390 WP_009988467.1 metal-sulfur cluster assembly factor -
SULA_RS13380 (SULA_2638) 2460040..2460471 - 432 WP_009988468.1 universal stress protein -
SULA_RS13385 (SULA_2639) 2460734..2461693 + 960 WP_010923364.1 IS5-like element ISC1234 family transposase -
SULA_RS13390 (SULA_2640) 2462130..2463062 - 933 WP_009988516.1 dipeptidase -
SULA_RS13395 (SULA_2641) 2463007..2464203 - 1197 WP_009988517.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2460734..2461693 959


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Bacterioopsin activator-type, HTH domain

(145-197)

Antitoxin

Protein of unknown function DUF488

(3-108)


Sequences

Toxin        


Download         Length: 205 a.a.        Molecular weight: 23424.52 Da        Isoelectric Point: 8.6438

>T53254 WP_009988462.1 NZ_CP011057:c2458900-2458286 [Saccharolobus solfataricus]
MLKSPFEATILIEEHPCEVMKIISSTGLKGVVDNVKLGDNTTDHIVLFEKEVQKDDLIKLKSHSTKVLRLNDNKIWVRTY
GCAVCKILYTSNVVVEKIKVVRERTLLYTLLIPNTMALKEFLASLISQDIEFTVLSTSEISSNELTDRQMEILKLAYKMG
YFDDDRRVTLTELAKQLGISTPTLEEILRRALRKVVKFYLDKVR

Download         Length: 615 bp

>T53254 NZ_CP011057:c2458900-2458286 [Saccharolobus solfataricus]
ATGTTAAAATCACCATTTGAAGCAACAATCCTAATTGAGGAGCACCCTTGTGAAGTAATGAAGATAATATCTAGTACTGG
GCTTAAAGGTGTTGTTGATAACGTTAAACTTGGAGATAATACAACCGATCACATAGTACTTTTCGAAAAAGAGGTCCAAA
AAGATGATCTAATTAAGCTTAAATCGCATAGTACTAAGGTTTTAAGGCTTAACGATAACAAGATATGGGTTAGAACTTAC
GGATGTGCAGTATGTAAGATTCTATATACTTCAAACGTCGTTGTAGAGAAAATAAAGGTAGTAAGAGAGAGGACATTGCT
CTATACTCTCTTAATCCCTAATACGATGGCACTTAAGGAATTTCTGGCAAGCCTCATAAGTCAAGATATAGAGTTTACAG
TGCTAAGCACTTCTGAAATAAGTAGTAATGAGTTAACTGATAGACAAATGGAAATATTGAAGCTTGCGTATAAGATGGGT
TATTTCGATGACGATAGGAGGGTTACTTTAACTGAGCTAGCAAAACAATTGGGAATTTCTACACCAACTTTAGAGGAGAT
TTTGCGTAGGGCTTTAAGGAAAGTTGTCAAGTTTTACTTAGATAAGGTAAGATAG

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13662.96 Da        Isoelectric Point: 9.9061

>AT53254 WP_009988464.1 NZ_CP011057:c2459265-2458918 [Saccharolobus solfataricus]
MIKLKRVYDPIERDDGIRILVDRLWPRGIGKDKVDLWLKDIAPSDELRKWFSHDTSKWDEFKKKYFEELDANPKISVLLQ
LIKKGENITLLYASKSPYNNAVALKEYLEKKILKQ

Download         Length: 348 bp

>AT53254 NZ_CP011057:c2459265-2458918 [Saccharolobus solfataricus]
ATGATTAAATTAAAGAGAGTTTACGATCCAATAGAAAGGGATGATGGAATAAGGATCTTAGTGGATAGGTTATGGCCAAG
AGGTATTGGCAAGGATAAAGTCGATTTGTGGCTCAAAGACATAGCGCCTAGTGATGAATTACGAAAGTGGTTTAGTCACG
ATACTAGTAAATGGGACGAGTTCAAAAAGAAATATTTTGAAGAATTAGATGCTAATCCAAAGATAAGCGTACTATTACAA
TTAATTAAAAAAGGTGAAAATATTACTTTACTTTACGCTTCAAAGTCACCGTATAATAATGCAGTAGCGTTAAAGGAGTA
TCTAGAAAAAAAGATATTAAAACAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E3MDP8

Antitoxin

Source ID Structure
AlphaFold DB A0A0E3GU05

References