Detailed information of TA system TA053253

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-AbrB
• Location: 2403911..2404558
• Replicon: chromosome
• Accession: NZ_CP011057
• Organism: Saccharolobus solfataricus strain SULA isolate 98/2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: SULA_RS13020
• Protein ID: WP_009990357.1
• Coordinates: 2403911..2404183 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A0E3K976
• Locus tag: SULA_RS13025
• Protein ID: WP_009990356.1
• Coordinates: 2404298..2404558 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SULA_RS13005 (SULA_2567)	2399226..2400277	-	1052	Protein_2569	ISH3-like element ISC1359 family transposase	-
SULA_RS13010 (SULA_2568)	2400381..2401130	+	750	Protein_2570	GDP-mannose 4,6-dehydratase	-
SULA_RS13015 (SULA_2571)	2402441..2403388	-	948	WP_009990359.1	ATP/GTP-binding protein	-
SULA_RS13020 (SULA_2572)	2403911..2404183	-	273	WP_009990357.1	PIN domain-containing protein	Toxin
SULA_RS13025 (SULA_2573)	2404298..2404558	-	261	WP_009990356.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
SULA_RS13030 (SULA_03775)	2405245..2405406	+	162	WP_009990355.1	hypothetical protein	-
SULA_RS13035 (SULA_2574)	2405508..2405966	+	459	WP_009990354.1	hypothetical protein	-
SULA_RS13040 (SULA_2575)	2406715..2407221	-	507	WP_014511696.1	thiosulfate:quinone oxidoreductase small subunit	-
SULA_RS13045 (SULA_2576)	2407227..2407769	-	543	WP_009990352.1	thiosulfate:quinone oxidoreductase large subunit	-
SULA_RS13050 (SULA_2577)	2408077..2408952	-	876	Protein_2578	transposase	-
SULA_RS13055 (SULA_2578)	2409313..2409546	+	234	WP_009993269.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (20-82)

Antitoxin

• SpoVT-AbrB domain (7-46)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10475.34 Da
• Isoelectric Point: 9.7534

>T53253 WP_009990357.1 NZ_CP011057:c2404183-2403911 [Saccharolobus solfataricus]
MRLFTLSKKKYNVKFEDTIDFLDKIILPYTIILPINSHDYEKAKGIMISKTLKPSDAFHVAVMINNSIKKIVSEDSDFDK
INGIERIWVK

Nucleotide

• Length: 273 bp

>T53253 NZ_CP011057:c2404183-2403911 [Saccharolobus solfataricus]
ATGAGGTTATTTACATTATCAAAAAAGAAGTATAATGTAAAATTTGAGGATACAATTGATTTCTTAGATAAGATAATACT
TCCTTATACAATTATACTGCCAATCAACTCTCATGATTATGAAAAAGCAAAGGGGATAATGATAAGTAAGACTTTAAAAC
CGTCTGATGCTTTCCACGTAGCTGTAATGATAAATAATTCAATAAAAAAGATAGTAAGTGAGGATTCAGATTTCGATAAA
ATTAATGGAATAGAAAGGATTTGGGTAAAATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9842.51 Da
• Isoelectric Point: 5.2456

>AT53253 WP_009990356.1 NZ_CP011057:c2404558-2404298 [Saccharolobus solfataricus]
MTLKIEVGKKGYIIIPKTVRDLLEIKEGDILILRVEDGKIVLEPERKVSFDDLKKKMEEHSAKISYANKAKLGDLINVSL
EEEFDN

Nucleotide

• Length: 261 bp

>AT53253 NZ_CP011057:c2404558-2404298 [Saccharolobus solfataricus]
TTGACCCTAAAGATTGAAGTTGGAAAGAAAGGATATATAATAATCCCTAAGACTGTTAGGGATCTTCTTGAAATAAAGGA
GGGAGATATATTAATCCTAAGAGTCGAAGATGGTAAAATTGTTCTTGAGCCTGAAAGAAAGGTAAGTTTTGATGACTTAA
AAAAGAAGATGGAGGAACATAGTGCTAAAATCTCATATGCAAATAAGGCTAAACTTGGAGATTTAATTAACGTTAGTTTA
GAGGAGGAATTCGATAATTGA

Structures

Antitoxin

• AlphaFold DB: A0A0E3K976