Detailed information of TA system TA053252

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2197454..2198141
• Replicon: chromosome
• Accession: NZ_CP011057
• Organism: Saccharolobus solfataricus strain SULA isolate 98/2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: SULA_RS11995
• Protein ID: WP_231918326.1
• Coordinates: 2197806..2198141 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: SULA_RS11990
• Protein ID: WP_009991659.1
• Coordinates: 2197454..2197756 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SULA_RS11970 (SULA_2359)	2193378..2193921	-	544	Protein_2356	IS607 family transposase	-
SULA_RS11975 (SULA_2360)	2194249..2194916	+	668	Protein_2357	ISNCY family transposase	-
SULA_RS11980 (SULA_2361)	2195325..2195897	-	573	WP_010923431.1	metallophosphoesterase	-
SULA_RS11985 (SULA_03595)	2195913..2196925	-	1013	Protein_2359	IS630-like element ISC1078 family transposase	-
SULA_RS11990 (SULA_2364)	2197454..2197756	+	303	WP_009991659.1	hypothetical protein	Antitoxin
SULA_RS11995 (SULA_2365)	2197806..2198141	+	336	WP_231918326.1	type II toxin-antitoxin system VapC family toxin	Toxin
SULA_RS12000 (SULA_2366)	2198349..2199464	+	1116	WP_009991657.1	hypothetical protein	-
SULA_RS12005 (SULA_2367)	2199608..2199943	-	336	Protein_2363	transposase	-
SULA_RS12010 (SULA_03600)	2200125..2200270	-	146	Protein_2364	IS630 family transposase	-
SULA_RS15025	2200215..2200406	+	192	WP_048056702.1	hypothetical protein	-
SULA_RS12020 (SULA_2369)	2200666..2201163	-	498	WP_014511660.1	hypothetical protein	-
SULA_RS12025 (SULA_2370)	2201305..2202278	-	974	Protein_2367	IS5 family transposase	-
SULA_RS12030 (SULA_2371)	2202403..2202741	+	339	WP_010923427.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2156637..2370256	213619
	-	inside	IScluster/Tn	-	-	2192144..2205920	13776

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (9-104)

Antitoxin

• Putative antitoxin VapB3-like (28-100)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12427.61 Da
• Isoelectric Point: 5.2389

>T53252 WP_231918326.1 NZ_CP011057:2197806-2198141 [Saccharolobus solfataricus]
IREILKDAETLDFALVEVSNVVWKKAVLTGELTGKDVIKAITIVKEYLPQLLTVNKSIDLIERAIEISVNEKITVYDSLY
IALAECKGSKLVTGDKKQYDVAKKYVISELI

Nucleotide

• Length: 336 bp

>T53252 NZ_CP011057:2197806-2198141 [Saccharolobus solfataricus]
ATTAGAGAGATTTTGAAAGACGCTGAGACATTAGACTTCGCATTAGTGGAAGTATCTAACGTAGTATGGAAGAAAGCTGT
ATTAACTGGGGAATTAACTGGGAAAGATGTAATTAAGGCAATTACTATTGTTAAAGAGTATTTACCACAACTGCTTACAG
TTAACAAAAGCATTGACTTAATTGAAAGAGCTATTGAGATTTCCGTTAACGAGAAAATCACAGTATATGATTCACTTTAT
ATTGCACTGGCTGAATGTAAGGGGAGTAAATTGGTAACGGGGGATAAGAAACAATACGACGTAGCTAAAAAGTACGTCAT
CTCTGAGCTCATATAG

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 12195.09 Da
• Isoelectric Point: 4.8275

>AT53252 WP_009991659.1 NZ_CP011057:2197454-2197756 [Saccharolobus solfataricus]
MVIKNATILIYVPEIETFIFPVYVYYNMKTVYSLRLDKELREEMEKYNVKWNEEIESFIRKRIEELKKEEILKKINEILQ
TMPETKSNSADLVREDRDNN

Nucleotide

• Length: 303 bp

>AT53252 NZ_CP011057:2197454-2197756 [Saccharolobus solfataricus]
ATGGTAATAAAGAATGCTACAATTTTAATCTATGTACCAGAGATAGAAACGTTTATATTTCCCGTATACGTGTATTATAA
TATGAAAACCGTATACAGTTTAAGGTTAGATAAGGAATTACGTGAGGAGATGGAGAAATATAACGTCAAGTGGAATGAGG
AGATAGAGAGCTTTATAAGAAAGAGAATTGAGGAATTGAAGAAAGAGGAGATCTTAAAGAAGATTAATGAAATCCTCCAA
ACAATGCCAGAAACTAAGTCAAATAGTGCAGATTTGGTGAGGGAAGATAGGGATAATAATTGA