Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2197454..2198141 Replicon chromosome
Accession NZ_CP011057
Organism Saccharolobus solfataricus strain SULA isolate 98/2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag SULA_RS11995 Protein ID WP_231918326.1
Coordinates 2197806..2198141 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag SULA_RS11990 Protein ID WP_009991659.1
Coordinates 2197454..2197756 (+) Length 101 a.a.

Genomic Context

SULA_RS11975SULA_RS11990SULA_RS11995SULA_RS12000SULA_RS15025SULA_RS12030SULA_RS11970SULA_RS11980SULA_RS11985SULA_RS12005SULA_RS12010SULA_RS12020SULA_RS12025
Location: 2194249..2194916 (668 bp)
Type: Others
Protein ID: Protein_2357
Location: 2197454..2197756 (303 bp)
Type: Antitoxin
Protein ID: WP_009991659.1
Location: 2197806..2198141 (336 bp)
Type: Toxin
Protein ID: WP_231918326.1
Location: 2198349..2199464 (1116 bp)
Type: Others
Protein ID: WP_009991657.1
Location: 2200215..2200406 (192 bp)
Type: Others
Protein ID: WP_048056702.1
Location: 2202403..2202741 (339 bp)
Type: Others
Protein ID: WP_010923427.1
Location: 2193378..2193921 (544 bp)
Type: Others
Protein ID: Protein_2356
Location: 2195325..2195897 (573 bp)
Type: Others
Protein ID: WP_010923431.1
Location: 2195913..2196925 (1013 bp)
Type: Others
Protein ID: Protein_2359
Location: 2199608..2199943 (336 bp)
Type: Others
Protein ID: Protein_2363
Location: 2200125..2200270 (146 bp)
Type: Others
Protein ID: Protein_2364
Location: 2200666..2201163 (498 bp)
Type: Others
Protein ID: WP_014511660.1
Location: 2201305..2202278 (974 bp)
Type: Others
Protein ID: Protein_2367
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
SULA_RS11970 (SULA_2359)2193378..2193921-544Protein_2356IS607 family transposase-
SULA_RS11975 (SULA_2360)2194249..2194916+668Protein_2357ISNCY family transposase-
SULA_RS11980 (SULA_2361)2195325..2195897-573WP_010923431.1metallophosphoesterase-
SULA_RS11985 (SULA_03595)2195913..2196925-1013Protein_2359IS630-like element ISC1078 family transposase-
SULA_RS11990 (SULA_2364)2197454..2197756+303WP_009991659.1hypothetical proteinAntitoxin
SULA_RS11995 (SULA_2365)2197806..2198141+336WP_231918326.1type II toxin-antitoxin system VapC family toxinToxin
SULA_RS12000 (SULA_2366)2198349..2199464+1116WP_009991657.1hypothetical protein-
SULA_RS12005 (SULA_2367)2199608..2199943-336Protein_2363transposase-
SULA_RS12010 (SULA_03600)2200125..2200270-146Protein_2364IS630 family transposase-
SULA_RS150252200215..2200406+192WP_048056702.1hypothetical protein-
SULA_RS12020 (SULA_2369)2200666..2201163-498WP_014511660.1hypothetical protein-
SULA_RS12025 (SULA_2370)2201305..2202278-974Protein_2367IS5 family transposase-
SULA_RS12030 (SULA_2371)2202403..2202741+339WP_010923427.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideIntegrative and Conjugative Element--2156637..2370256213619
-insideIScluster/Tn--2192144..220592013776


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-104)

Antitoxin

Putative antitoxin VapB3-like

(28-100)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12427.61 Da        Isoelectric Point: 5.2389

>T53252 WP_231918326.1 NZ_CP011057:2197806-2198141 [Saccharolobus solfataricus]
IREILKDAETLDFALVEVSNVVWKKAVLTGELTGKDVIKAITIVKEYLPQLLTVNKSIDLIERAIEISVNEKITVYDSLY
IALAECKGSKLVTGDKKQYDVAKKYVISELI

Download         Length: 336 bp

>T53252 NZ_CP011057:2197806-2198141 [Saccharolobus solfataricus]
ATTAGAGAGATTTTGAAAGACGCTGAGACATTAGACTTCGCATTAGTGGAAGTATCTAACGTAGTATGGAAGAAAGCTGT
ATTAACTGGGGAATTAACTGGGAAAGATGTAATTAAGGCAATTACTATTGTTAAAGAGTATTTACCACAACTGCTTACAG
TTAACAAAAGCATTGACTTAATTGAAAGAGCTATTGAGATTTCCGTTAACGAGAAAATCACAGTATATGATTCACTTTAT
ATTGCACTGGCTGAATGTAAGGGGAGTAAATTGGTAACGGGGGATAAGAAACAATACGACGTAGCTAAAAAGTACGTCAT
CTCTGAGCTCATATAG

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 12195.09 Da        Isoelectric Point: 4.8275

>AT53252 WP_009991659.1 NZ_CP011057:2197454-2197756 [Saccharolobus solfataricus]
MVIKNATILIYVPEIETFIFPVYVYYNMKTVYSLRLDKELREEMEKYNVKWNEEIESFIRKRIEELKKEEILKKINEILQ
TMPETKSNSADLVREDRDNN

Download         Length: 303 bp

>AT53252 NZ_CP011057:2197454-2197756 [Saccharolobus solfataricus]
ATGGTAATAAAGAATGCTACAATTTTAATCTATGTACCAGAGATAGAAACGTTTATATTTCCCGTATACGTGTATTATAA
TATGAAAACCGTATACAGTTTAAGGTTAGATAAGGAATTACGTGAGGAGATGGAGAAATATAACGTCAAGTGGAATGAGG
AGATAGAGAGCTTTATAAGAAAGAGAATTGAGGAATTGAAGAAAGAGGAGATCTTAAAGAAGATTAATGAAATCCTCCAA
ACAATGCCAGAAACTAAGTCAAATAGTGCAGATTTGGTGAGGGAAGATAGGGATAATAATTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
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Antitoxin

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Source
ID
Structure
No matching records found

References