Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-AbrB
Location 825215..825821 Replicon chromosome
Accession NZ_CP011057
Organism Saccharolobus solfataricus strain SULA isolate 98/2

Toxin (Protein)


Gene name vapC Uniprot ID Q97UE3
Locus tag SULA_RS04300 Protein ID WP_009989090.1
Coordinates 825215..825619 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M9UBQ9
Locus tag SULA_RS04305 Protein ID WP_009989091.1
Coordinates 825600..825821 (-) Length 74 a.a.

Genomic Context

SULA_RS04280SULA_RS04285SULA_RS04295SULA_RS04310SULA_RS04315SULA_RS04320SULA_RS04325SULA_RS04265SULA_RS04270SULA_RS04290SULA_RS04300SULA_RS04305SULA_RS04330SULA_RS04335
Location: 822644..823423 (780 bp)
Type: Others
Protein ID: WP_014511459.1
Location: 823861..824585 (725 bp)
Type: Others
Protein ID: Protein_861
Location: 824732..825019 (288 bp)
Type: Others
Protein ID: WP_272898411.1
Location: 826350..826550 (201 bp)
Type: Others
Protein ID: WP_009989095.1
Location: 826604..826834 (231 bp)
Type: Others
Protein ID: WP_009989096.1
Location: 826945..828216 (1272 bp)
Type: Others
Protein ID: WP_009989097.1
Location: 828335..829000 (666 bp)
Type: Others
Protein ID: WP_009989098.1
Location: 820717..821478 (762 bp)
Type: Others
Protein ID: WP_009990867.1
Location: 821626..821808 (183 bp)
Type: Others
Protein ID: WP_009990866.1
Location: 824583..824690 (108 bp)
Type: Others
Protein ID: Protein_862
Location: 825215..825619 (405 bp)
Type: Toxin
Protein ID: WP_009989090.1
Location: 825600..825821 (222 bp)
Type: Antitoxin
Protein ID: WP_009989091.1
Location: 828997..829383 (387 bp)
Type: Others
Protein ID: WP_009989099.1
Location: 829380..829997 (618 bp)
Type: Others
Protein ID: WP_009989100.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
SULA_RS04265 (SULA_0849)820717..821478-762WP_009990867.1ZIP family metal transporter-
SULA_RS04270 (SULA_0850)821626..821808-183WP_009990866.1hypothetical protein-
SULA_RS04280 (SULA_0851)822644..823423+780WP_014511459.1DMT family transporter-
SULA_RS04285 (SULA_0852)823861..824585+725Protein_861transposase-
SULA_RS04290 (SULA_03170)824583..824690-108Protein_862IS110 family transposase-
SULA_RS04295 (SULA_03175)824732..825019+288WP_272898411.1transposase-
SULA_RS04300 (SULA_0854)825215..825619-405WP_009989090.1PIN domain-containing proteinToxin
SULA_RS04305 (SULA_0855)825600..825821-222WP_009989091.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
SULA_RS04310 (SULA_0856)826350..826550+201WP_009989095.1hypothetical protein-
SULA_RS04315 (SULA_0857)826604..826834+231WP_009989096.1EamA family transporter-
SULA_RS04320 (SULA_0858)826945..828216+1272WP_009989097.1MFS transporter-
SULA_RS04325 (SULA_0859)828335..829000+666WP_009989098.1helix-turn-helix domain-containing protein-
SULA_RS04330 (SULA_0860)828997..829383-387WP_009989099.1hypothetical protein-
SULA_RS04335 (SULA_0861)829380..829997-618WP_009989100.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-126)

Antitoxin

SpoVT-AbrB domain

(4-48)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15426.98 Da        Isoelectric Point: 5.0272

>T53250 WP_009989090.1 NZ_CP011057:c825619-825215 [Saccharolobus solfataricus]
VEKAIVDTNVIIYDYVEDSEYHKRAEELLDSLDRWVIPVIVVHEIMWFLKGMKLEDKVDDVLAYIRSEKAEVVCDCTDNV
TDAIGVLNKEKLPLVSYKDMVILSHAIREKLPLATFDRKLSKIAKKYSVSLLQS

Download         Length: 405 bp

>T53250 NZ_CP011057:c825619-825215 [Saccharolobus solfataricus]
GTGGAGAAGGCAATAGTTGACACTAACGTGATAATTTACGACTACGTTGAAGACTCCGAATATCATAAGAGGGCGGAAGA
GCTTCTCGATAGTTTGGATAGGTGGGTAATTCCCGTGATTGTAGTTCATGAGATCATGTGGTTCTTAAAGGGCATGAAAC
TTGAAGACAAGGTAGATGACGTTTTGGCTTATATTAGAAGTGAGAAAGCTGAGGTTGTCTGCGATTGTACAGATAACGTC
ACTGACGCTATAGGAGTGCTGAATAAGGAAAAGCTTCCCTTGGTCAGCTACAAAGATATGGTAATACTTTCTCACGCAAT
TAGAGAAAAATTGCCTTTAGCCACTTTTGATAGGAAACTCTCAAAGATAGCAAAGAAGTACTCCGTAAGTTTGCTACAGT
CGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8267.50 Da        Isoelectric Point: 9.6908

>AT53250 WP_009989091.1 NZ_CP011057:c825821-825600 [Saccharolobus solfataricus]
MERVKVTRNYQITIPASARSKINIKEGDILEVYLNGDEIVLRKVKTERPRIRLGSKLSLGDIEEAIERGEGNS

Download         Length: 222 bp

>AT53250 NZ_CP011057:c825821-825600 [Saccharolobus solfataricus]
ATGGAGAGGGTAAAGGTTACGAGAAATTACCAGATAACTATTCCAGCCTCGGCTAGGAGTAAGATTAATATAAAAGAAGG
AGATATACTTGAGGTTTACTTGAACGGTGACGAGATAGTACTTCGGAAGGTTAAGACTGAGAGGCCGAGGATAAGGCTAG
GCAGTAAACTCTCACTGGGAGATATTGAGGAGGCAATAGAGCGTGGAGAAGGCAATAGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0E3K068

Antitoxin

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Source
ID
Structure
AlphaFold DBM9UBQ9

References