Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-AbrB
Location 825215..825821 Replicon chromosome
Accession NZ_CP011057
Organism Saccharolobus solfataricus strain SULA isolate 98/2

Toxin (Protein)


Gene name vapC Uniprot ID Q97UE3
Locus tag SULA_RS04300 Protein ID WP_009989090.1
Coordinates 825215..825619 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M9UBQ9
Locus tag SULA_RS04305 Protein ID WP_009989091.1
Coordinates 825600..825821 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SULA_RS04265 (SULA_0849) 820717..821478 - 762 WP_009990867.1 ZIP family metal transporter -
SULA_RS04270 (SULA_0850) 821626..821808 - 183 WP_009990866.1 hypothetical protein -
SULA_RS04280 (SULA_0851) 822644..823423 + 780 WP_014511459.1 DMT family transporter -
SULA_RS04285 (SULA_0852) 823861..824585 + 725 Protein_861 transposase -
SULA_RS04290 (SULA_03170) 824583..824690 - 108 Protein_862 IS110 family transposase -
SULA_RS04295 (SULA_03175) 824732..825019 + 288 WP_272898411.1 transposase -
SULA_RS04300 (SULA_0854) 825215..825619 - 405 WP_009989090.1 PIN domain-containing protein Toxin
SULA_RS04305 (SULA_0855) 825600..825821 - 222 WP_009989091.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
SULA_RS04310 (SULA_0856) 826350..826550 + 201 WP_009989095.1 hypothetical protein -
SULA_RS04315 (SULA_0857) 826604..826834 + 231 WP_009989096.1 EamA family transporter -
SULA_RS04320 (SULA_0858) 826945..828216 + 1272 WP_009989097.1 MFS transporter -
SULA_RS04325 (SULA_0859) 828335..829000 + 666 WP_009989098.1 helix-turn-helix domain-containing protein -
SULA_RS04330 (SULA_0860) 828997..829383 - 387 WP_009989099.1 hypothetical protein -
SULA_RS04335 (SULA_0861) 829380..829997 - 618 WP_009989100.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-126)

Antitoxin

SpoVT-AbrB domain

(4-48)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15426.98 Da        Isoelectric Point: 5.0272

>T53250 WP_009989090.1 NZ_CP011057:c825619-825215 [Saccharolobus solfataricus]
VEKAIVDTNVIIYDYVEDSEYHKRAEELLDSLDRWVIPVIVVHEIMWFLKGMKLEDKVDDVLAYIRSEKAEVVCDCTDNV
TDAIGVLNKEKLPLVSYKDMVILSHAIREKLPLATFDRKLSKIAKKYSVSLLQS

Download         Length: 405 bp

>T53250 NZ_CP011057:c825619-825215 [Saccharolobus solfataricus]
GTGGAGAAGGCAATAGTTGACACTAACGTGATAATTTACGACTACGTTGAAGACTCCGAATATCATAAGAGGGCGGAAGA
GCTTCTCGATAGTTTGGATAGGTGGGTAATTCCCGTGATTGTAGTTCATGAGATCATGTGGTTCTTAAAGGGCATGAAAC
TTGAAGACAAGGTAGATGACGTTTTGGCTTATATTAGAAGTGAGAAAGCTGAGGTTGTCTGCGATTGTACAGATAACGTC
ACTGACGCTATAGGAGTGCTGAATAAGGAAAAGCTTCCCTTGGTCAGCTACAAAGATATGGTAATACTTTCTCACGCAAT
TAGAGAAAAATTGCCTTTAGCCACTTTTGATAGGAAACTCTCAAAGATAGCAAAGAAGTACTCCGTAAGTTTGCTACAGT
CGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8267.50 Da        Isoelectric Point: 9.6908

>AT53250 WP_009989091.1 NZ_CP011057:c825821-825600 [Saccharolobus solfataricus]
MERVKVTRNYQITIPASARSKINIKEGDILEVYLNGDEIVLRKVKTERPRIRLGSKLSLGDIEEAIERGEGNS

Download         Length: 222 bp

>AT53250 NZ_CP011057:c825821-825600 [Saccharolobus solfataricus]
ATGGAGAGGGTAAAGGTTACGAGAAATTACCAGATAACTATTCCAGCCTCGGCTAGGAGTAAGATTAATATAAAAGAAGG
AGATATACTTGAGGTTTACTTGAACGGTGACGAGATAGTACTTCGGAAGGTTAAGACTGAGAGGCCGAGGATAAGGCTAG
GCAGTAAACTCTCACTGGGAGATATTGAGGAGGCAATAGAGCGTGGAGAAGGCAATAGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E3K068

Antitoxin

Source ID Structure
AlphaFold DB M9UBQ9

References