Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2597060..2597666 Replicon chromosome
Accession NZ_CP011056
Organism Saccharolobus solfataricus strain SARC-C

Toxin (Protein)


Gene name vapC Uniprot ID Q97WY9
Locus tag SULC_RS14175 Protein ID WP_009991922.1
Coordinates 2597274..2597666 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID C3NC15
Locus tag SULC_RS14170 Protein ID WP_009991920.1
Coordinates 2597060..2597284 (+) Length 75 a.a.

Genomic Context

SULC_RS14140SULC_RS14145SULC_RS14160SULC_RS14165SULC_RS14170SULC_RS14175SULC_RS14180SULC_RS14190SULC_RS14195SULC_RS14135SULC_RS14150SULC_RS14155SULC_RS14185
Location: 2593404..2593688 (285 bp)
Type: Others
Protein ID: Protein_2799
Location: 2593672..2594892 (1221 bp)
Type: Others
Protein ID: WP_014511730.1
Location: 2596059..2596295 (237 bp)
Type: Others
Protein ID: WP_009991916.1
Location: 2596273..2596671 (399 bp)
Type: Others
Protein ID: WP_009991918.1
Location: 2597060..2597284 (225 bp)
Type: Antitoxin
Protein ID: WP_009991920.1
Location: 2597274..2597666 (393 bp)
Type: Toxin
Protein ID: WP_009991922.1
Location: 2597842..2598792 (951 bp)
Type: Others
Protein ID: WP_052885475.1
Location: 2600016..2601131 (1116 bp)
Type: Others
Protein ID: WP_009988843.1
Location: 2601194..2602339 (1146 bp)
Type: Others
Protein ID: WP_009988841.1
Location: 2592295..2593245 (951 bp)
Type: Others
Protein ID: WP_010923701.1
Location: 2595040..2595426 (387 bp)
Type: Others
Protein ID: WP_009991912.1
Location: 2595413..2595688 (276 bp)
Type: Others
Protein ID: WP_009991915.1
Location: 2598866..2599915 (1050 bp)
Type: Others
Protein ID: Protein_2808
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
SULC_RS14135 (SULC_2788)2592295..2593245-951WP_010923701.1IS110 family transposase-
SULC_RS14140 (SULC_2789)2593404..2593688+285Protein_2799IS607-like element ISC1913 family transposase-
SULC_RS14145 (SULC_2790)2593672..2594892+1221WP_014511730.1IS200/IS605 family accessory protein TnpB-related protein-
SULC_RS14150 (SULC_2791)2595040..2595426-387WP_009991912.1type II toxin-antitoxin system VapC family toxin-
SULC_RS14155 (SULC_2792)2595413..2595688-276WP_009991915.1AbrB/MazE/SpoVT family DNA-binding domain-containing protein-
SULC_RS14160 (SULC_2793)2596059..2596295+237WP_009991916.1AbrB/MazE/SpoVT family DNA-binding domain-containing protein-
SULC_RS14165 (SULC_2794)2596273..2596671+399WP_009991918.1type II toxin-antitoxin system VapC family toxin-
SULC_RS14170 (SULC_2795)2597060..2597284+225WP_009991920.1type II toxin-antitoxin system CcdA family antitoxinAntitoxin
SULC_RS14175 (SULC_2796)2597274..2597666+393WP_009991922.1type II toxin-antitoxin system VapC family toxinToxin
SULC_RS14180 (SULC_2797)2597842..2598792+951WP_052885475.1IS110 family transposase-
SULC_RS14185 (SULC_2798)2598866..2599915-1050Protein_2808AMP-binding protein-
SULC_RS14190 (SULC_2799)2600016..2601131+1116WP_009988843.1acyl-CoA dehydrogenase family protein-
SULC_RS14195 (SULC_2800)2601194..2602339+1146WP_009988841.1thiolase domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideIScluster/Tn--2591863..25987926929


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(23-118)

Antitoxin

Post-segregation antitoxin CcdA

(5-44)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 15105.86 Da        Isoelectric Point: 8.2957

>T53249 WP_009991922.1 NZ_CP011056:2597274-2597666 [Saccharolobus solfataricus]
MKDKEFLFDASALYSLLDYVDKIDLKKIHILTLTFYEVGNVIWKEYYIHKKVKDPITLSMLFHKLMRKLNIVEDPPLEGV
MRIAVERGLTYYDASYAYVAESLGLILVSNDKELIRKANAISLKDLIKSM

Download         Length: 393 bp

>T53249 NZ_CP011056:2597274-2597666 [Saccharolobus solfataricus]
ATGAAAGATAAGGAATTCCTATTCGATGCCTCAGCTTTGTACTCGCTTTTAGATTACGTGGATAAAATAGACTTAAAGAA
AATTCATATACTTACCCTAACTTTTTATGAGGTAGGTAACGTCATATGGAAGGAGTATTATATACATAAAAAGGTTAAAG
ATCCTATAACTCTTTCGATGCTTTTCCATAAATTAATGCGAAAACTTAACATAGTAGAGGATCCACCTCTTGAGGGAGTA
ATGAGAATTGCCGTAGAAAGGGGTTTGACTTACTATGACGCATCTTATGCATATGTTGCTGAATCTTTAGGGCTTATCCT
AGTGTCTAACGATAAAGAGCTGATAAGAAAAGCTAATGCTATTTCATTAAAAGATTTGATAAAAAGTATGTGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8881.24 Da        Isoelectric Point: 5.0355

>AT53249 WP_009991920.1 NZ_CP011056:2597060-2597284 [Saccharolobus solfataricus]
MSDVISVRVKKELKKRAEELGINIREVVEKALEEAIREKEKEELKDIVMRIKELMRDVSEDDWVRAVRESRDER

Download         Length: 225 bp

>AT53249 NZ_CP011056:2597060-2597284 [Saccharolobus solfataricus]
ATGTCAGACGTAATAAGCGTAAGGGTTAAGAAAGAGCTGAAGAAGAGGGCAGAGGAGTTGGGAATTAACATTAGGGAAGT
TGTAGAAAAAGCTTTAGAAGAGGCCATAAGGGAGAAGGAGAAGGAAGAGCTTAAGGATATAGTTATGAGAATTAAGGAAC
TAATGAGAGATGTAAGTGAAGATGATTGGGTAAGGGCTGTTAGGGAGAGTAGGGATGAAAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0E3K6Y2

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0E3MHL6

References