Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-AbrB
Location 2595040..2595688 Replicon chromosome
Accession NZ_CP011056
Organism Saccharolobus solfataricus strain SARC-C

Toxin (Protein)


Gene name vapC Uniprot ID Q97WZ2
Locus tag SULC_RS14150 Protein ID WP_009991912.1
Coordinates 2595040..2595426 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q97WZ1
Locus tag SULC_RS14155 Protein ID WP_009991915.1
Coordinates 2595413..2595688 (-) Length 92 a.a.

Genomic Context

SULC_RS14130SULC_RS14140SULC_RS14145SULC_RS14160SULC_RS14165SULC_RS14170SULC_RS14175SULC_RS14180SULC_RS14120SULC_RS14125SULC_RS14135SULC_RS14150SULC_RS14155SULC_RS14185
Location: 2591863..2592219 (357 bp)
Type: Others
Protein ID: Protein_2797
Location: 2593404..2593688 (285 bp)
Type: Others
Protein ID: Protein_2799
Location: 2593672..2594892 (1221 bp)
Type: Others
Protein ID: WP_014511730.1
Location: 2596059..2596295 (237 bp)
Type: Others
Protein ID: WP_009991916.1
Location: 2596273..2596671 (399 bp)
Type: Others
Protein ID: WP_009991918.1
Location: 2597060..2597284 (225 bp)
Type: Others
Protein ID: WP_009991920.1
Location: 2597274..2597666 (393 bp)
Type: Others
Protein ID: WP_009991922.1
Location: 2597842..2598792 (951 bp)
Type: Others
Protein ID: WP_052885475.1
Location: 2590122..2590895 (774 bp)
Type: Others
Protein ID: WP_009991748.1
Location: 2591151..2591576 (426 bp)
Type: Others
Protein ID: WP_009991747.1
Location: 2592295..2593245 (951 bp)
Type: Others
Protein ID: WP_010923701.1
Location: 2595040..2595426 (387 bp)
Type: Toxin
Protein ID: WP_009991912.1
Location: 2595413..2595688 (276 bp)
Type: Antitoxin
Protein ID: WP_009991915.1
Location: 2598866..2599915 (1050 bp)
Type: Others
Protein ID: Protein_2808
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
SULC_RS14120 (SULC_2785)2590122..2590895-774WP_009991748.1extradiol dioxygenase-
SULC_RS14125 (SULC_2786)2591151..2591576-426WP_009991747.1DUF4143 domain-containing protein-
SULC_RS14130 (SULC_2787)2591863..2592219+357Protein_2797IS607 family transposase-
SULC_RS14135 (SULC_2788)2592295..2593245-951WP_010923701.1IS110 family transposase-
SULC_RS14140 (SULC_2789)2593404..2593688+285Protein_2799IS607-like element ISC1913 family transposase-
SULC_RS14145 (SULC_2790)2593672..2594892+1221WP_014511730.1IS200/IS605 family accessory protein TnpB-related protein-
SULC_RS14150 (SULC_2791)2595040..2595426-387WP_009991912.1type II toxin-antitoxin system VapC family toxinToxin
SULC_RS14155 (SULC_2792)2595413..2595688-276WP_009991915.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
SULC_RS14160 (SULC_2793)2596059..2596295+237WP_009991916.1AbrB/MazE/SpoVT family DNA-binding domain-containing protein-
SULC_RS14165 (SULC_2794)2596273..2596671+399WP_009991918.1type II toxin-antitoxin system VapC family toxin-
SULC_RS14170 (SULC_2795)2597060..2597284+225WP_009991920.1type II toxin-antitoxin system CcdA family antitoxin-
SULC_RS14175 (SULC_2796)2597274..2597666+393WP_009991922.1type II toxin-antitoxin system VapC family toxin-
SULC_RS14180 (SULC_2797)2597842..2598792+951WP_052885475.1IS110 family transposase-
SULC_RS14185 (SULC_2798)2598866..2599915-1050Protein_2808AMP-binding protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideIScluster/Tn--2591863..25987926929


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

SpoVT-AbrB domain

(6-48)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 15042.69 Da        Isoelectric Point: 4.9844

>T53248 WP_009991912.1 NZ_CP011056:c2595426-2595040 [Saccharolobus solfataricus]
MIFLDANFLIYLNSGVSEVKEYYIKLLTYESLFSDPLVIDEVIYVSKKKYGVKYCDTIEFLDEIVLKYLTVLPITIKEYE
RAKEIMRKYSVKPSDAFHIAVMLNNSINVILSEDKELDKVAEIKRIWI

Download         Length: 387 bp

>T53248 NZ_CP011056:c2595426-2595040 [Saccharolobus solfataricus]
TTGATTTTTCTTGATGCTAATTTCTTAATCTACTTAAACTCGGGTGTAAGTGAGGTAAAAGAGTATTATATAAAACTCCT
CACATATGAAAGCTTGTTTTCAGATCCTTTAGTTATAGATGAGGTAATATACGTGTCTAAGAAGAAGTATGGAGTTAAGT
ATTGCGATACCATAGAATTCTTGGATGAAATAGTGCTCAAGTACTTAACAGTTTTACCAATCACGATAAAGGAATATGAG
AGGGCTAAAGAAATTATGAGAAAATACTCAGTTAAGCCATCTGATGCCTTTCATATTGCCGTAATGTTAAACAATTCAAT
AAACGTGATCTTAAGTGAAGATAAGGAGTTAGATAAAGTTGCAGAAATAAAGAGAATATGGATTTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10372.22 Da        Isoelectric Point: 7.0185

>AT53248 WP_009991915.1 NZ_CP011056:c2595688-2595413 [Saccharolobus solfataricus]
MSLTLRVEVGKKGYIIIPKSVRDLVGIKEGDILILTVVGDKIILEPERKVNIREVVKKLEEHERKISYAKRASLGELENI
SLEEELKIDFS

Download         Length: 276 bp

>AT53248 NZ_CP011056:c2595688-2595413 [Saccharolobus solfataricus]
ATGAGTTTGACTCTAAGAGTGGAAGTTGGAAAGAAGGGTTATATAATAATTCCTAAAAGTGTAAGGGATTTGGTGGGAAT
AAAAGAGGGGGATATCTTAATTTTGACAGTCGTTGGAGATAAGATAATCTTAGAACCTGAGAGGAAGGTTAACATACGAG
AAGTTGTCAAAAAATTAGAAGAACATGAGAGGAAGATATCTTATGCTAAAAGGGCAAGCCTTGGGGAACTTGAGAACATA
AGTCTTGAAGAGGAATTGAAGATTGATTTTTCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0E3KDP7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0E3MDU1

References