Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-AbrB
Location 2403911..2404558 Replicon chromosome
Accession NZ_CP011056
Organism Saccharolobus solfataricus strain SARC-C

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag SULC_RS13020 Protein ID WP_009990357.1
Coordinates 2403911..2404183 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E3K976
Locus tag SULC_RS13025 Protein ID WP_009990356.1
Coordinates 2404298..2404558 (-) Length 87 a.a.

Genomic Context

SULC_RS13010SULC_RS13030SULC_RS13035SULC_RS13055SULC_RS13005SULC_RS13015SULC_RS13020SULC_RS13025SULC_RS13040SULC_RS13045SULC_RS13050
Location: 2400381..2401130 (750 bp)
Type: Others
Protein ID: Protein_2570
Location: 2405245..2405406 (162 bp)
Type: Others
Protein ID: WP_009990355.1
Location: 2405508..2405966 (459 bp)
Type: Others
Protein ID: WP_009990354.1
Location: 2409313..2409546 (234 bp)
Type: Others
Protein ID: WP_009993269.1
Location: 2399226..2400277 (1052 bp)
Type: Others
Protein ID: Protein_2569
Location: 2402441..2403388 (948 bp)
Type: Others
Protein ID: WP_009990359.1
Location: 2403911..2404183 (273 bp)
Type: Toxin
Protein ID: WP_009990357.1
Location: 2404298..2404558 (261 bp)
Type: Antitoxin
Protein ID: WP_009990356.1
Location: 2406715..2407221 (507 bp)
Type: Others
Protein ID: WP_014511696.1
Location: 2407227..2407769 (543 bp)
Type: Others
Protein ID: WP_009990352.1
Location: 2408077..2408952 (876 bp)
Type: Others
Protein ID: Protein_2578
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
SULC_RS13005 (SULC_2564)2399226..2400277-1052Protein_2569ISH3-like element ISC1359 family transposase-
SULC_RS13010 (SULC_2565)2400381..2401130+750Protein_2570GDP-mannose 4,6-dehydratase-
SULC_RS13015 (SULC_2568)2402441..2403388-948WP_009990359.1ATP/GTP-binding protein-
SULC_RS13020 (SULC_2569)2403911..2404183-273WP_009990357.1PIN domain-containing proteinToxin
SULC_RS13025 (SULC_2570)2404298..2404558-261WP_009990356.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
SULC_RS13030 (SULC_03770)2405245..2405406+162WP_009990355.1hypothetical protein-
SULC_RS13035 (SULC_2571)2405508..2405966+459WP_009990354.1hypothetical protein-
SULC_RS13040 (SULC_2572)2406715..2407221-507WP_014511696.1thiosulfate:quinone oxidoreductase small subunit-
SULC_RS13045 (SULC_2573)2407227..2407769-543WP_009990352.1thiosulfate:quinone oxidoreductase large subunit-
SULC_RS13050 (SULC_2574)2408077..2408952-876Protein_2578transposase-
SULC_RS13055 (SULC_2575)2409313..2409546+234WP_009993269.1AbrB/MazE/SpoVT family DNA-binding domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(20-82)

Antitoxin

SpoVT-AbrB domain

(7-46)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10475.34 Da        Isoelectric Point: 9.7534

>T53246 WP_009990357.1 NZ_CP011056:c2404183-2403911 [Saccharolobus solfataricus]
MRLFTLSKKKYNVKFEDTIDFLDKIILPYTIILPINSHDYEKAKGIMISKTLKPSDAFHVAVMINNSIKKIVSEDSDFDK
INGIERIWVK

Download         Length: 273 bp

>T53246 NZ_CP011056:c2404183-2403911 [Saccharolobus solfataricus]
ATGAGGTTATTTACATTATCAAAAAAGAAGTATAATGTAAAATTTGAGGATACAATTGATTTCTTAGATAAGATAATACT
TCCTTATACAATTATACTGCCAATCAACTCTCATGATTATGAAAAAGCAAAGGGGATAATGATAAGTAAGACTTTAAAAC
CGTCTGATGCTTTCCACGTAGCTGTAATGATAAATAATTCAATAAAAAAGATAGTAAGTGAGGATTCAGATTTCGATAAA
ATTAATGGAATAGAAAGGATTTGGGTAAAATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9842.51 Da        Isoelectric Point: 5.2456

>AT53246 WP_009990356.1 NZ_CP011056:c2404558-2404298 [Saccharolobus solfataricus]
MTLKIEVGKKGYIIIPKTVRDLLEIKEGDILILRVEDGKIVLEPERKVSFDDLKKKMEEHSAKISYANKAKLGDLINVSL
EEEFDN

Download         Length: 261 bp

>AT53246 NZ_CP011056:c2404558-2404298 [Saccharolobus solfataricus]
TTGACCCTAAAGATTGAAGTTGGAAAGAAAGGATATATAATAATCCCTAAGACTGTTAGGGATCTTCTTGAAATAAAGGA
GGGAGATATATTAATCCTAAGAGTCGAAGATGGTAAAATTGTTCTTGAGCCTGAAAGAAAGGTAAGTTTTGATGACTTAA
AAAAGAAGATGGAGGAACATAGTGCTAAAATCTCATATGCAAATAAGGCTAAACTTGGAGATTTAATTAACGTTAGTTTA
GAGGAGGAATTCGATAATTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0E3K976

References