Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2043872..2044478 Replicon chromosome
Accession NZ_CP011056
Organism Saccharolobus solfataricus strain SARC-C

Toxin (Protein)


Gene name vapC Uniprot ID Q97YS3
Locus tag SULC_RS11365 Protein ID WP_009993017.1
Coordinates 2044086..2044478 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E3MAZ1
Locus tag SULC_RS11360 Protein ID WP_014511634.1
Coordinates 2043872..2044096 (+) Length 75 a.a.

Genomic Context

SULC_RS11335SULC_RS11340SULC_RS11350SULC_RS11355SULC_RS11360SULC_RS11365SULC_RS11375SULC_RS11345SULC_RS11370SULC_RS11380SULC_RS11385SULC_RS11390
Location: 2039020..2040150 (1131 bp)
Type: Others
Protein ID: WP_009992604.1
Location: 2040147..2040608 (462 bp)
Type: Others
Protein ID: WP_010923265.1
Location: 2041611..2042594 (984 bp)
Type: Others
Protein ID: WP_010923242.1
Location: 2042593..2043562 (970 bp)
Type: Others
Protein ID: Protein_2232
Location: 2043872..2044096 (225 bp)
Type: Antitoxin
Protein ID: WP_014511634.1
Location: 2044086..2044478 (393 bp)
Type: Toxin
Protein ID: WP_009993017.1
Location: 2045517..2046569 (1053 bp)
Type: Others
Protein ID: WP_010923271.1
Location: 2040651..2041566 (916 bp)
Type: Others
Protein ID: Protein_2230
Location: 2044921..2045399 (479 bp)
Type: Others
Protein ID: Protein_2235
Location: 2046757..2047344 (588 bp)
Type: Others
Protein ID: Protein_2237
Location: 2047778..2048119 (342 bp)
Type: Others
Protein ID: WP_009990179.1
Location: 2048110..2048457 (348 bp)
Type: Others
Protein ID: WP_014511635.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
SULC_RS11335 (SULC_2231)2039020..2040150+1131WP_009992604.1aromatic/alkene monooxygenase hydroxylase subunit beta-
SULC_RS11340 (SULC_2232)2040147..2040608+462WP_010923265.1metal-sulfur cluster assembly factor-
SULC_RS11345 (SULC_2233)2040651..2041566-916Protein_2230IS110 family transposase-
SULC_RS11350 (SULC_2234)2041611..2042594+984WP_010923242.1IS630-like element ISC1048 family transposase-
SULC_RS11355 (SULC_2235)2042593..2043562+970Protein_2232IS110 family transposase-
SULC_RS11360 (SULC_2236)2043872..2044096+225WP_014511634.1type II toxin-antitoxin system CcdA family antitoxinAntitoxin
SULC_RS11365 (SULC_2237)2044086..2044478+393WP_009993017.1type II toxin-antitoxin system VapC family toxinToxin
SULC_RS11370 (SULC_03505)2044921..2045399-479Protein_2235ISNCY family transposase-
SULC_RS11375 (SULC_2239)2045517..2046569+1053WP_010923271.1ISH3 family transposase-
SULC_RS11380 (SULC_2240)2046757..2047344-588Protein_2237ISNCY family transposase-
SULC_RS11385 (SULC_2241)2047778..2048119-342WP_009990179.1nucleotidyltransferase domain-containing protein-
SULC_RS11390 (SULC_2242)2048110..2048457-348WP_014511635.1HEPN domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--2035595..204734411749
-insideIScluster/Tn--2034750..204734412594


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(8-124)

Antitoxin

Post-segregation antitoxin CcdA

(5-49)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 15117.81 Da        Isoelectric Point: 9.3474

>T53244 WP_009993017.1 NZ_CP011056:2044086-2044478 [Saccharolobus solfataricus]
MKDKEFLLDASALYSLLDYVDKVDVKKIHVLTLTFYEVGNVIWKEYYIHKKVKDPITLSRLFYKLMRKFNVIEDSPLEGV
MRIAIERGLTYYNASYAYVAESLGLILVSNDKELIRKANAISLKDLIKSM

Download         Length: 393 bp

>T53244 NZ_CP011056:2044086-2044478 [Saccharolobus solfataricus]
ATGAAAGATAAGGAATTCTTGCTCGATGCCTCAGCTTTGTATTCACTTTTAGATTACGTGGATAAGGTAGATGTTAAGAA
AATTCATGTACTTACCCTAACTTTTTATGAGGTAGGTAATGTCATATGGAAGGAGTATTATATACATAAAAAGGTTAAAG
ATCCTATAACCCTTTCGAGGCTTTTCTATAAATTAATGCGAAAATTTAACGTAATAGAGGATTCGCCTCTTGAGGGGGTA
ATGAGAATTGCCATAGAAAGGGGTTTAACTTACTATAACGCATCTTATGCGTATGTTGCTGAATCTTTAGGGCTTATCCT
AGTGTCTAACGATAAAGAGTTGATAAGAAAGGCTAACGCTATTTCGTTAAAGGATTTGATAAAAAGTATGTGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8792.11 Da        Isoelectric Point: 4.8365

>AT53244 WP_014511634.1 NZ_CP011056:2043872-2044096 [Saccharolobus solfataricus]
MSDVISVRVKKELKKKAEELGINVREVVEKALEEAIREKEKEELKDMTMKIKELMRDVSEDDWVSTVRESRDER

Download         Length: 225 bp

>AT53244 NZ_CP011056:2043872-2044096 [Saccharolobus solfataricus]
ATGTCAGACGTAATAAGCGTAAGAGTGAAGAAAGAGCTAAAGAAGAAGGCAGAGGAGTTAGGAATTAACGTTAGGGAAGT
TGTAGAAAAAGCTTTAGAGGAAGCCATAAGGGAGAAGGAGAAGGAAGAGCTTAAGGATATGACTATGAAAATTAAGGAAC
TAATGAGGGACGTAAGTGAAGATGATTGGGTAAGTACTGTTAGGGAGAGTAGGGATGAAAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0E3GVD1

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0E3MAZ1

References