Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2043872..2044478 Replicon chromosome
Accession NZ_CP011055
Organism Saccharolobus solfataricus strain SARC-B

Toxin (Protein)


Gene name vapC Uniprot ID Q97YS3
Locus tag SULB_RS11365 Protein ID WP_009993017.1
Coordinates 2044086..2044478 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E3MAZ1
Locus tag SULB_RS11360 Protein ID WP_014511634.1
Coordinates 2043872..2044096 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SULB_RS11335 (SULB_2234) 2039020..2040150 + 1131 WP_009992604.1 aromatic/alkene monooxygenase hydroxylase subunit beta -
SULB_RS11340 (SULB_2235) 2040147..2040608 + 462 WP_010923265.1 metal-sulfur cluster assembly factor -
SULB_RS11345 (SULB_2236) 2040651..2041566 - 916 Protein_2230 IS110 family transposase -
SULB_RS11350 (SULB_2237) 2041611..2042594 + 984 WP_010923242.1 IS630-like element ISC1048 family transposase -
SULB_RS11355 (SULB_2238) 2042593..2043562 + 970 Protein_2232 IS110 family transposase -
SULB_RS11360 (SULB_2239) 2043872..2044096 + 225 WP_014511634.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
SULB_RS11365 (SULB_2240) 2044086..2044478 + 393 WP_009993017.1 type II toxin-antitoxin system VapC family toxin Toxin
SULB_RS11370 (SULB_03515) 2044921..2045399 - 479 Protein_2235 ISNCY family transposase -
SULB_RS11375 (SULB_2242) 2045517..2046569 + 1053 WP_010923271.1 ISH3 family transposase -
SULB_RS11380 (SULB_2243) 2046757..2047344 - 588 Protein_2237 ISNCY family transposase -
SULB_RS11385 (SULB_2244) 2047778..2048119 - 342 WP_009990179.1 nucleotidyltransferase domain-containing protein -
SULB_RS11390 (SULB_2245) 2048110..2048457 - 348 WP_014511635.1 HEPN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2035595..2047344 11749
- inside IScluster/Tn - - 2034750..2047344 12594


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(8-124)

Antitoxin

Post-segregation antitoxin CcdA

(5-49)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 15117.81 Da        Isoelectric Point: 9.3474

>T53237 WP_009993017.1 NZ_CP011055:2044086-2044478 [Saccharolobus solfataricus]
MKDKEFLLDASALYSLLDYVDKVDVKKIHVLTLTFYEVGNVIWKEYYIHKKVKDPITLSRLFYKLMRKFNVIEDSPLEGV
MRIAIERGLTYYNASYAYVAESLGLILVSNDKELIRKANAISLKDLIKSM

Download         Length: 393 bp

>T53237 NZ_CP011055:2044086-2044478 [Saccharolobus solfataricus]
ATGAAAGATAAGGAATTCTTGCTCGATGCCTCAGCTTTGTATTCACTTTTAGATTACGTGGATAAGGTAGATGTTAAGAA
AATTCATGTACTTACCCTAACTTTTTATGAGGTAGGTAATGTCATATGGAAGGAGTATTATATACATAAAAAGGTTAAAG
ATCCTATAACCCTTTCGAGGCTTTTCTATAAATTAATGCGAAAATTTAACGTAATAGAGGATTCGCCTCTTGAGGGGGTA
ATGAGAATTGCCATAGAAAGGGGTTTAACTTACTATAACGCATCTTATGCGTATGTTGCTGAATCTTTAGGGCTTATCCT
AGTGTCTAACGATAAAGAGTTGATAAGAAAGGCTAACGCTATTTCGTTAAAGGATTTGATAAAAAGTATGTGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8792.11 Da        Isoelectric Point: 4.8365

>AT53237 WP_014511634.1 NZ_CP011055:2043872-2044096 [Saccharolobus solfataricus]
MSDVISVRVKKELKKKAEELGINVREVVEKALEEAIREKEKEELKDMTMKIKELMRDVSEDDWVSTVRESRDER

Download         Length: 225 bp

>AT53237 NZ_CP011055:2043872-2044096 [Saccharolobus solfataricus]
ATGTCAGACGTAATAAGCGTAAGAGTGAAGAAAGAGCTAAAGAAGAAGGCAGAGGAGTTAGGAATTAACGTTAGGGAAGT
TGTAGAAAAAGCTTTAGAGGAAGCCATAAGGGAGAAGGAGAAGGAAGAGCTTAAGGATATGACTATGAAAATTAAGGAAC
TAATGAGGGACGTAAGTGAAGATGATTGGGTAAGTACTGTTAGGGAGAGTAGGGATGAAAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E3GVD1

Antitoxin

Source ID Structure
AlphaFold DB A0A0E3MAZ1

References