Detailed information of TA system TA053234

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/COG5606-COG4679
• Location: 3970627..3971309
• Replicon: chromosome
• Accession: NZ_CP011052
• Organism: Halomonas sp. KO116

Toxin (Protein)

• Gene name: tad
• Uniprot ID: A0A0D5M7T8
• Locus tag: KO116_RS18105
• Protein ID: WP_035564542.1
• Coordinates: 3970627..3970989 (+)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: KO116_RS18110
• Protein ID: WP_035564544.1
• Coordinates: 3970989..3971309 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KO116_RS18085	3966436..3967806	+	1371	WP_082072642.1	glycosyltransferase	-
KO116_RS25140	3968147..3968644	+	498	WP_139041605.1	hypothetical protein	-
KO116_RS18090	3968649..3968966	+	318	WP_008959750.1	helix-turn-helix domain-containing protein	-
KO116_RS24200	3968987..3969661	-	675	WP_008959751.1	DUF2726 domain-containing protein	-
KO116_RS18100	3969886..3970161	-	276	WP_008959752.1	putative addiction module antidote protein	-
KO116_RS18105	3970627..3970989	+	363	WP_035564542.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KO116_RS18110	3970989..3971309	+	321	WP_035564544.1	helix-turn-helix domain-containing protein	Antitoxin
KO116_RS24795	3971321..3971632	+	312	WP_082072643.1	DUF4124 domain-containing protein	-
KO116_RS18115	3971656..3971988	-	333	WP_035564546.1	hypothetical protein	-
KO116_RS18125	3972199..3972483	-	285	WP_045812171.1	helix-turn-helix domain-containing protein	-
KO116_RS24800	3972632..3972793	+	162	WP_082072690.1	helix-turn-helix domain-containing protein	-
KO116_RS18135	3972793..3973500	+	708	WP_035564551.1	hypothetical protein	-
KO116_RS18140	3973874..3974209	+	336	WP_035564552.1	hypothetical protein	-
KO116_RS18145	3974429..3974686	+	258	WP_045812172.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	3970409..3981812	11403

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (17-110)

Antitoxin

• Cro/C1-type helix-turn-helix domain (33-84)

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13419.30 Da
• Isoelectric Point: 9.8845

>T53234 WP_035564542.1 NZ_CP011052:3970627-3970989 [Halomonas sp. KO116]
MDSKSPKPLRWVASSKKDLQAMPEDVKDVFGFALHLAQSGSKHTQTKPLKGFRSAGVLEVVEDYQGDTYRAVYTVRIQEA
VYVLHCFQKKSSTGISTPKPDIDKIRDRLKAAEQHAKGET

Nucleotide

• Length: 363 bp

>T53234 NZ_CP011052:3970627-3970989 [Halomonas sp. KO116]
ATGGATAGCAAATCACCAAAACCTTTGCGATGGGTAGCTAGCTCAAAAAAAGATCTCCAAGCCATGCCCGAGGATGTGAA
AGATGTTTTCGGCTTCGCGCTTCACCTAGCTCAATCCGGTTCAAAACACACTCAAACTAAGCCACTCAAAGGCTTTCGCT
CGGCTGGTGTTCTTGAGGTAGTGGAAGATTACCAGGGTGATACCTACCGCGCGGTTTACACGGTTCGCATCCAGGAAGCG
GTATATGTACTTCACTGCTTTCAAAAAAAGTCATCCACGGGGATCTCCACACCCAAACCCGATATAGACAAAATTCGTGA
CCGATTGAAAGCGGCAGAACAACACGCCAAAGGAGAAACCTAA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 11562.50 Da
• Isoelectric Point: 9.7892

>AT53234 WP_035564544.1 NZ_CP011052:3970989-3971309 [Halomonas sp. KO116]
MIIEESTGNVYDDIHSNDADEMLIKAQLAAKIGDVIKRRRLTQVKVAELTGLPQPKVSAMLKGQFRGISESKMLECLAKL
GRDVRIVVGPARPRSTPGHVALEING

Nucleotide

• Length: 321 bp

>AT53234 NZ_CP011052:3970989-3971309 [Halomonas sp. KO116]
ATGATCATTGAAGAAAGCACCGGCAACGTCTACGACGATATCCACAGCAATGATGCCGATGAAATGCTTATCAAAGCACA
GCTTGCCGCCAAGATCGGCGACGTGATCAAACGCCGCCGTCTTACCCAGGTTAAAGTAGCTGAATTGACCGGCTTGCCAC
AGCCCAAAGTTTCAGCAATGCTAAAAGGCCAGTTTCGGGGCATTAGTGAATCCAAAATGCTGGAATGCCTCGCCAAACTT
GGCCGAGATGTACGCATTGTGGTGGGTCCGGCTCGCCCACGCTCAACACCAGGGCATGTTGCGCTAGAAATTAATGGTTA
A

Structures

Toxin

• AlphaFold DB: A0A0D5M7T8