Detailed information of TA system TA053233

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 3743287..3744404
• Replicon: chromosome
• Accession: NZ_CP011052
• Organism: Halomonas sp. KO116

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: KO116_RS17055
• Protein ID: WP_200897182.1
• Coordinates: 3743287..3744030 (-)
• Length: 248 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A0D5M688
• Locus tag: KO116_RS17060
• Protein ID: WP_035563853.1
• Coordinates: 3744033..3744404 (-)
• Length: 124 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KO116_RS17045	3739143..3742616	+	3474	WP_035563859.1	acyl-[ACP]--phospholipid O-acyltransferase	-
KO116_RS17050	3742786..3743196	-	411	Protein_3381	prolyl oligopeptidase family serine peptidase	-
KO116_RS17055	3743287..3744030	-	744	WP_200897182.1	RES family NAD+ phosphorylase	Toxin
KO116_RS17060	3744033..3744404	-	372	WP_035563853.1	helix-turn-helix domain-containing protein	Antitoxin
KO116_RS17065	3744571..3746298	-	1728	WP_035563850.1	mechanosensitive ion channel family protein	-
KO116_RS17070	3746486..3747025	-	540	WP_035563847.1	GDYXXLXY domain-containing protein	-
KO116_RS17075	3747022..3748113	-	1092	WP_045812163.1	DUF4401 domain-containing protein	-
KO116_RS17080	3748110..3749084	-	975	WP_035563844.1	DUF2157 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (60-204)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (70-121)

Sequences

Toxin

Protein

• Length: 248 a.a.
• Molecular weight: 27910.47 Da
• Isoelectric Point: 4.9966

>T53233 WP_200897182.1 NZ_CP011052:c3744030-3743287 [Halomonas sp. KO116]
VWEACGGERNIEPISGTLYRLVESQEQVATLSYVDTLEEQEMLEALLETAKPPYPEQERDLHYLLKTPFRYPPLKWGSRF
GRVFEPSIFYGGKGIATTLAESAYYRWVFWYSMEGEPVSASLRSEHTLFSVDYAAKRGVRLNAGPFIEHFPALKHPVDYT
PCQQLGSAMRTADIDAFEYASARDSQGAACVGLFTPEALTQYEPADMRPWLCVTSATQVSFKRKDASGVYTYHLDDFLHH
GVLPFPA

Nucleotide

• Length: 744 bp

>T53233 NZ_CP011052:c3744030-3743287 [Halomonas sp. KO116]
GTGTGGGAAGCTTGTGGTGGCGAGCGAAATATCGAACCTATTTCCGGCACCCTTTATCGACTGGTGGAGAGTCAGGAGCA
AGTCGCAACGCTTAGCTATGTCGACACGTTAGAAGAGCAGGAGATGCTTGAAGCACTGCTTGAAACGGCTAAACCGCCTT
ACCCTGAACAGGAGCGAGACCTGCACTATCTTCTAAAAACCCCTTTTCGGTATCCCCCTCTCAAATGGGGGTCACGTTTT
GGCCGTGTGTTTGAGCCAAGTATTTTCTATGGTGGTAAGGGTATTGCTACCACTCTCGCTGAATCTGCCTACTACCGATG
GGTTTTCTGGTACTCCATGGAAGGTGAACCTGTTTCCGCGTCGCTGCGTTCGGAGCATACGCTCTTTTCTGTAGACTATG
CCGCTAAACGGGGAGTGAGACTAAATGCAGGCCCCTTTATCGAACACTTTCCGGCGTTGAAGCATCCGGTTGATTACACT
CCATGTCAGCAATTGGGTAGTGCAATGCGTACGGCGGACATTGATGCATTTGAGTACGCCTCCGCAAGAGATAGTCAGGG
TGCTGCGTGCGTGGGCTTGTTTACCCCTGAAGCGCTTACCCAGTATGAGCCAGCCGATATGCGCCCTTGGCTTTGTGTCA
CAAGTGCCACTCAAGTGTCATTTAAGCGCAAAGACGCATCAGGCGTTTATACCTACCACCTGGATGATTTTCTCCACCAC
GGTGTGTTGCCTTTTCCAGCTTAG

Antitoxin

Protein

• Length: 124 a.a.
• Molecular weight: 13492.81 Da
• Isoelectric Point: 10.8729

>AT53233 WP_035563853.1 NZ_CP011052:c3744404-3744033 [Halomonas sp. KO116]
MPAITQTKPSSEMVLAKAVLRAAEQLGLSQSELAEVLGVHRTTITQLKKNLKLDPNSKQGELALLLIRLARALFALTGGD
QEWIQHFMRTSNRVTGGIPAEQVTRLEGLFAVLRFVDGMRGKV

Nucleotide

• Length: 372 bp

>AT53233 NZ_CP011052:c3744404-3744033 [Halomonas sp. KO116]
ATGCCAGCCATTACTCAAACAAAGCCCAGCTCTGAAATGGTGTTAGCTAAAGCAGTTCTGCGTGCAGCTGAGCAGTTGGG
GTTATCGCAGTCTGAGTTGGCAGAGGTGCTAGGCGTACATCGAACGACCATTACCCAGCTTAAAAAAAACCTGAAGCTTG
ACCCGAACTCTAAGCAGGGCGAACTAGCTCTGCTGCTTATTCGCTTGGCTCGAGCTTTATTCGCGCTTACCGGAGGCGAC
CAAGAATGGATTCAGCATTTTATGCGCACATCCAACCGCGTGACTGGTGGCATTCCGGCCGAGCAGGTAACACGGTTGGA
GGGGCTGTTTGCAGTACTGAGATTCGTGGATGGTATGCGGGGTAAAGTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A0D5M688