Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 369937..370847 Replicon chromosome
Accession NZ_CP011052
Organism Halomonas sp. KO116

Toxin (Protein)


Gene name - Uniprot ID A0A0D5LY97
Locus tag KO116_RS01795 Protein ID WP_035555225.1
Coordinates 369937..370401 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0D5LY25
Locus tag KO116_RS01800 Protein ID WP_035555227.1
Coordinates 370398..370847 (-) Length 150 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KO116_RS01770 365077..365796 + 720 WP_035555210.1 urea ABC transporter ATP-binding subunit UrtE -
KO116_RS01775 365894..366814 - 921 WP_035555213.1 metal ABC transporter permease -
KO116_RS01780 366811..367917 - 1107 WP_035555216.1 metal ABC transporter permease -
KO116_RS01785 367921..368703 - 783 WP_035555219.1 ABC transporter ATP-binding protein -
KO116_RS01790 368726..369694 - 969 WP_035555222.1 zinc ABC transporter substrate-binding protein -
KO116_RS01795 369937..370401 - 465 WP_035555225.1 RES family NAD+ phosphorylase Toxin
KO116_RS01800 370398..370847 - 450 WP_035555227.1 DUF2384 domain-containing protein Antitoxin
KO116_RS01805 371108..371992 + 885 WP_035555229.1 urease accessory protein UreD -
KO116_RS01810 372030..372332 + 303 WP_022521353.1 urease subunit gamma -
KO116_RS01815 372357..372677 + 321 WP_035555232.1 urease subunit beta -
KO116_RS01820 372674..374389 + 1716 WP_035555235.1 urease subunit alpha -
KO116_RS01825 374564..375079 + 516 WP_035555238.1 urease accessory protein UreE -
KO116_RS01830 375057..375824 + 768 WP_200897154.1 urease accessory protein UreF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(6-149)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(98-146)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 16922.15 Da        Isoelectric Point: 4.1475

>T53231 WP_035555225.1 NZ_CP011052:c370401-369937 [Halomonas sp. KO116]
MNEVTAYRLVKRKFQETAFDGEGARLYGGRWNSPGNACVYVASSESLALLETMVNLESYRLLNAYALLRLTLPADTILSV
GEEDLPENWQEAPAPAETAELGDGWLASNQSLALAVPSVVVPRELNYMLNTAHPLFDQIIATAEALPFQPDPRL

Download         Length: 465 bp

>T53231 NZ_CP011052:c370401-369937 [Halomonas sp. KO116]
ATGAACGAGGTCACCGCCTATCGGCTGGTTAAGCGTAAGTTTCAGGAAACAGCGTTTGATGGCGAGGGCGCACGGCTTTA
CGGTGGGCGCTGGAACAGCCCGGGGAATGCCTGTGTGTATGTGGCAAGCTCCGAGTCGCTGGCGCTACTGGAAACTATGG
TGAATCTGGAAAGCTATCGGCTGCTCAATGCGTATGCGCTGCTGCGCCTAACGCTGCCAGCAGACACCATTCTAAGCGTT
GGCGAAGAAGATCTACCGGAAAACTGGCAGGAAGCCCCAGCGCCCGCAGAGACTGCTGAACTTGGCGATGGCTGGCTGGC
ATCCAACCAAAGTCTGGCACTGGCAGTGCCGAGCGTGGTCGTGCCGAGAGAGCTCAACTACATGCTCAATACGGCGCACC
CCTTATTCGATCAAATCATCGCGACGGCCGAGGCACTGCCCTTCCAGCCCGATCCAAGACTTTGA

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 16682.16 Da        Isoelectric Point: 10.0368

>AT53231 WP_035555227.1 NZ_CP011052:c370847-370398 [Halomonas sp. KO116]
MDIHFTQYQPPKALAPGFWQQVGLPARGRKLHELLHAGVEYRVYPQLAKVSGIEQKALARYVDIPSATLSRRAKSGRFKM
EESDRLYRFAELFKATLDLFEGDAEGARAWLLKPNAGLGGRRPVEMSATSAEYQTVLNLIGRLEHGVSV

Download         Length: 450 bp

>AT53231 NZ_CP011052:c370847-370398 [Halomonas sp. KO116]
ATGGATATCCATTTCACTCAATATCAGCCTCCCAAAGCTTTGGCGCCCGGATTCTGGCAGCAAGTTGGTCTGCCTGCTCG
CGGCCGTAAGCTGCATGAGCTGCTACATGCAGGCGTGGAATATCGTGTCTATCCCCAACTTGCCAAGGTATCAGGTATCG
AGCAGAAGGCCCTGGCGCGCTATGTGGATATTCCCTCTGCCACGCTCAGCCGTCGCGCCAAATCGGGCCGCTTCAAAATG
GAGGAGAGTGACCGGCTGTATCGCTTTGCTGAGCTTTTCAAGGCGACACTGGATCTATTCGAGGGGGACGCGGAGGGCGC
CCGCGCCTGGCTGCTCAAACCCAATGCCGGGCTAGGCGGTCGTCGCCCTGTCGAAATGAGCGCCACATCGGCGGAGTATC
AAACGGTGTTGAACCTCATCGGGCGGCTGGAGCACGGGGTCTCGGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D5LY97

Antitoxin

Source ID Structure
AlphaFold DB A0A0D5LY25

References