Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 46118..47721 Replicon plasmid CSK29544_1p
Accession NZ_CP011048
Organism Cronobacter sakazakii strain ATCC 29544

Toxin (Protein)


Gene name hipA Uniprot ID A0A7V7RBL7
Locus tag CSK29544_RS21575 Protein ID WP_007873333.1
Coordinates 46402..47721 (+) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A2S9U8H8
Locus tag CSK29544_RS21570 Protein ID WP_007887716.1
Coordinates 46118..46399 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSK29544_RS21550 41158..42105 - 948 WP_007887706.1 acetyltransferase -
CSK29544_RS21555 42098..43846 - 1749 WP_029039469.1 aerobactin synthase IucA -
CSK29544_RS21560 43982..45193 + 1212 WP_007887712.1 MFS transporter -
CSK29544_RS21565 45190..45987 + 798 WP_007887714.1 siderophore-interacting protein -
CSK29544_RS21570 46118..46399 + 282 WP_007887716.1 helix-turn-helix domain-containing protein Antitoxin
CSK29544_RS21575 46402..47721 + 1320 WP_007873333.1 type II toxin-antitoxin system HipA family toxin Toxin
CSK29544_RS21580 48027..49811 + 1785 WP_007887718.1 malto-oligosyltrehalose trehalohydrolase -
CSK29544_RS21585 49808..52339 + 2532 WP_007887720.1 malto-oligosyltrehalose synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - mgtB / iutA / iucC / iucB / iucA 1..93905 93905


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49069.04 Da        Isoelectric Point: 6.8213

>T53229 WP_007873333.1 NZ_CP011048:46402-47721 [Cronobacter sakazakii]
MRRTSRLALWMNGLPVGYWDKHNGEDRLTYLPEWIADPQGRPLSLSLPFTPGNQSYRGAQVRDYFDNLLPDSENIRRRLA
MRYRAQSLEPFDLLAELGRDCVGAIQLLPAGEAPEGLFTIRARPLTTVDIAAMLRHTAEAFPGQHGGEEELRLSIAGAQE
KTALLWHEGQWCLPEGNTPTTHIFKLPLGLVGNMQADMRTSIENEWLCAQLLEAWDIPVARTQMAQFDEQKVLIVERFDR
RLSADGQWWLRLPQEDMCQALGVSPLRKYQADGGPGIGDIMTVLSRSENAQADRANFFRAQIIFWILAATDGHAKNFSIA
HLPGNRYHLTPLYDVLSAWPVIGPGNNQIAWQKCKLAMAVRSGSNYYHLSQIRRRHWLRQGELAGLSAAQVNDMIDALTA
SAPAVIARVADALPVDFPASLADVIFNGMRQQCARLAAA

Download         Length: 1320 bp

>T53229 NZ_CP011048:46402-47721 [Cronobacter sakazakii]
ATGCGCCGCACGTCGCGTTTAGCGCTCTGGATGAACGGCCTGCCGGTCGGTTACTGGGATAAACACAACGGCGAAGACCG
GCTGACCTATCTGCCGGAGTGGATTGCCGATCCGCAGGGCAGGCCGCTGTCGCTGTCGCTGCCGTTCACGCCCGGTAATC
AGTCATACCGTGGCGCGCAGGTGCGCGATTACTTCGACAACCTGCTGCCGGACAGCGAAAACATCCGGCGGCGACTGGCG
ATGCGCTACCGGGCGCAGAGCCTGGAGCCGTTCGATCTGCTGGCGGAGCTGGGACGTGACTGCGTCGGCGCCATTCAGCT
GCTGCCTGCCGGTGAAGCGCCGGAAGGGCTCTTTACCATTCGCGCCCGGCCACTCACCACAGTGGATATTGCCGCGATGC
TGCGCCACACCGCAGAGGCCTTTCCCGGCCAGCATGGCGGGGAAGAGGAGCTGCGGCTCTCCATTGCGGGCGCGCAGGAG
AAAACCGCGCTGCTATGGCACGAAGGCCAGTGGTGCCTGCCGGAGGGCAATACGCCCACCACGCATATTTTCAAACTGCC
GCTGGGGCTGGTGGGCAATATGCAGGCGGACATGCGCACCTCGATTGAAAACGAATGGCTCTGCGCGCAGCTGCTGGAAG
CCTGGGATATTCCGGTCGCGCGCACGCAGATGGCGCAGTTCGATGAGCAAAAAGTGCTGATTGTCGAACGCTTCGACCGG
CGTCTTTCGGCCGATGGGCAGTGGTGGCTGCGTCTGCCGCAGGAAGATATGTGCCAGGCGCTCGGCGTCTCGCCGCTGCG
TAAATATCAGGCCGACGGCGGGCCGGGCATCGGTGATATCATGACGGTTCTGAGCCGTTCAGAAAACGCGCAGGCGGATC
GCGCGAATTTCTTCCGCGCGCAGATTATTTTCTGGATCCTCGCCGCGACCGACGGCCACGCCAAGAATTTCAGCATTGCG
CATCTGCCCGGCAACCGCTACCACCTGACGCCGCTTTACGACGTCCTTTCCGCCTGGCCGGTCATCGGACCGGGTAATAA
CCAGATAGCCTGGCAGAAGTGCAAGCTGGCGATGGCGGTGCGCAGCGGCAGTAACTATTACCATCTGAGCCAGATCCGCC
GCCGTCACTGGCTGCGCCAGGGCGAGCTTGCCGGGCTGTCGGCGGCGCAGGTCAACGACATGATTGATGCGCTGACAGCC
AGCGCGCCTGCGGTGATCGCGCGCGTGGCCGACGCGCTCCCGGTGGATTTCCCTGCCTCTCTGGCCGACGTTATTTTTAA
CGGCATGCGCCAGCAGTGCGCGCGCCTCGCGGCCGCATAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10560.07 Da        Isoelectric Point: 9.0637

>AT53229 WP_007887716.1 NZ_CP011048:46118-46399 [Cronobacter sakazakii]
MNTRYPLKTLSQLRPLLVGFRKKQGLTQKEVSARLGVTQQTYARLEANPETASIERLFRVFNVLGIEMTLCETQAAETDA
PARDDSPAHREVW

Download         Length: 282 bp

>AT53229 NZ_CP011048:46118-46399 [Cronobacter sakazakii]
ATGAACACCCGGTATCCACTGAAAACGCTCAGCCAGCTGCGCCCGCTGCTGGTGGGCTTTCGTAAAAAACAGGGGCTGAC
CCAGAAAGAGGTTTCGGCGCGGCTTGGCGTCACGCAGCAAACCTATGCGCGGCTGGAGGCGAACCCCGAAACGGCCAGCA
TCGAGCGCCTGTTCCGCGTCTTTAACGTGCTGGGCATTGAGATGACGCTGTGCGAAACGCAGGCGGCGGAGACTGACGCG
CCCGCGCGTGACGATTCGCCTGCCCACCGCGAGGTGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7V7RBL7

Antitoxin

Source ID Structure
AlphaFold DB A0A2S9U8H8

References