Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1781361..1782024 Replicon chromosome
Accession NZ_CP011047
Organism Cronobacter sakazakii strain ATCC 29544

Toxin (Protein)


Gene name cptA Uniprot ID A0A7V7RBD3
Locus tag CSK29544_RS08400 Protein ID WP_029039029.1
Coordinates 1781608..1782024 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A7V7RBN7
Locus tag CSK29544_RS08395 Protein ID WP_007892598.1
Coordinates 1781361..1781627 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSK29544_RS08370 1776390..1777823 - 1434 WP_007892604.1 6-phospho-beta-glucosidase -
CSK29544_RS08375 1777975..1778703 - 729 WP_032975612.1 MurR/RpiR family transcriptional regulator -
CSK29544_RS08380 1778879..1779193 + 315 WP_007892602.1 N(4)-acetylcytidine aminohydrolase -
CSK29544_RS08385 1779336..1779989 + 654 WP_007777939.1 hemolysin III family protein -
CSK29544_RS08390 1780094..1781083 - 990 WP_007892600.1 tRNA-modifying protein YgfZ -
CSK29544_RS08395 1781361..1781627 + 267 WP_007892598.1 FAD assembly factor SdhE Antitoxin
CSK29544_RS08400 1781608..1782024 + 417 WP_029039029.1 protein YgfX Toxin
CSK29544_RS08405 1782038..1782559 - 522 WP_004385676.1 flavodoxin FldB -
CSK29544_RS08410 1782661..1783557 + 897 WP_007892593.1 site-specific tyrosine recombinase XerD -
CSK29544_RS08415 1783580..1784299 + 720 WP_004385678.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CSK29544_RS08420 1784303..1786036 + 1734 WP_007870697.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 16342.30 Da        Isoelectric Point: 11.2018

>T53213 WP_029039029.1 NZ_CP011047:1781608-1782024 [Cronobacter sakazakii]
VVLWHSDLRVSWRSQWLSLLLHGAVAVIILLLPWPLRYLPVWMLLLSLVVFDCVRSQRRINAFQGEVSLTADYHLRWQGV
DWQICATPWMLRSGMMLRLGHPKTTRRHHVWLAADSMTEAEWRDLRRLLLQQPVGDKR

Download         Length: 417 bp

>T53213 NZ_CP011047:1781608-1782024 [Cronobacter sakazakii]
GTGGTCCTGTGGCACTCTGATCTTCGCGTTTCATGGCGCTCGCAGTGGCTATCGCTGCTGCTGCACGGCGCCGTGGCCGT
TATTATTTTGCTGCTCCCCTGGCCGCTGCGGTATCTGCCCGTGTGGATGCTGTTGCTGTCTCTGGTGGTGTTTGACTGCG
TACGTAGCCAGCGGCGTATCAATGCGTTCCAGGGCGAGGTCAGCCTGACGGCTGATTATCACCTTCGCTGGCAGGGCGTT
GACTGGCAGATTTGCGCCACGCCCTGGATGCTGCGCAGCGGAATGATGCTGCGGCTGGGTCATCCTAAAACGACACGCCG
CCATCATGTCTGGCTGGCGGCGGATAGCATGACGGAAGCAGAGTGGCGCGATTTGCGTCGCCTTCTGTTGCAACAGCCCG
TAGGCGACAAACGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10427.89 Da        Isoelectric Point: 4.8310

>AT53213 WP_007892598.1 NZ_CP011047:1781361-1781627 [Cronobacter sakazakii]
MDINNKARIHWACRRGMRELDISIMPFFEYDYDSLSDEDKRVFVRLLECDDPDLFNWLMNHGKPADSELARMVELIQQRN
QARGPVAL

Download         Length: 267 bp

>AT53213 NZ_CP011047:1781361-1781627 [Cronobacter sakazakii]
ATGGATATTAATAATAAAGCCCGTATTCACTGGGCATGTCGCAGAGGTATGCGCGAGCTGGATATTTCCATCATGCCTTT
CTTTGAATATGACTATGACTCCCTGAGCGACGAAGACAAACGCGTTTTTGTCCGCCTGCTGGAGTGTGACGATCCTGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCAGCTGATTCGGAGCTGGCGCGAATGGTGGAATTAATCCAGCAGCGGAAT
CAGGCACGTGGTCCTGTGGCACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7V7RBD3

Antitoxin

Source ID Structure
AlphaFold DB A0A7V7RBN7

References