Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 1425898..1426568 Replicon chromosome
Accession NZ_CP011047
Organism Cronobacter sakazakii strain ATCC 29544

Toxin (Protein)


Gene name tad Uniprot ID A0A7V7RAE9
Locus tag CSK29544_RS06680 Protein ID WP_007891559.1
Coordinates 1425898..1426248 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID A0A7V7RA28
Locus tag CSK29544_RS06685 Protein ID WP_007891558.1
Coordinates 1426245..1426568 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSK29544_RS06665 1423448..1425079 + 1632 WP_007891561.1 Na/Pi cotransporter family protein -
CSK29544_RS06670 1425096..1425371 - 276 WP_007852536.1 putative addiction module antidote protein -
CSK29544_RS06675 1425376..1425681 - 306 WP_029039415.1 type II toxin-antitoxin system RelE/ParE family toxin -
CSK29544_RS06680 1425898..1426248 + 351 WP_007891559.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CSK29544_RS06685 1426245..1426568 + 324 WP_007891558.1 helix-turn-helix domain-containing protein Antitoxin
CSK29544_RS06690 1426595..1426867 - 273 WP_007702377.1 DUF3811 domain-containing protein -
CSK29544_RS06695 1426958..1427893 - 936 WP_007891556.1 ketopantoate/pantoate/pantothenate transporter PanS -
CSK29544_RS06700 1428055..1429647 - 1593 WP_007891554.1 RNA repair transcriptional activator RtcR -
CSK29544_RS06710 1430123..1431256 + 1134 WP_029039413.1 slipin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1425096..1433287 8191


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-90)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12982.04 Da        Isoelectric Point: 10.0998

>T53211 WP_007891559.1 NZ_CP011047:1425898-1426248 [Cronobacter sakazakii]
MIKPLFWVGQARKDLQALPEDVQDLFGYALYLAQQGRRHPQARPLKGFGGAGVLEVVEDYQGNAFRAVYTVCLKDAIYVL
HVFQKKSSSGIATPRPEMEKIEQRLKAAQRHAGGLK

Download         Length: 351 bp

>T53211 NZ_CP011047:1425898-1426248 [Cronobacter sakazakii]
ATGATAAAACCGTTGTTTTGGGTCGGGCAGGCCAGAAAAGATCTTCAGGCGCTGCCGGAGGATGTACAGGATCTTTTTGG
CTATGCGCTTTATCTGGCGCAGCAGGGTAGACGCCATCCGCAGGCCAGGCCGCTTAAAGGTTTTGGCGGCGCGGGTGTAC
TTGAGGTGGTGGAGGATTATCAGGGGAATGCCTTTCGGGCGGTCTATACCGTGTGCCTGAAAGATGCGATTTATGTCCTG
CACGTATTCCAGAAAAAATCCTCTTCCGGGATTGCCACGCCCCGCCCGGAGATGGAAAAAATTGAACAACGACTGAAAGC
CGCGCAACGCCACGCCGGAGGGCTGAAATGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11781.84 Da        Isoelectric Point: 6.3117

>AT53211 WP_007891558.1 NZ_CP011047:1426245-1426568 [Cronobacter sakazakii]
MTADIERSNGNVYDDLGLIDAEEMQLKAQLAMAVSDILKARGLTQQEAARLLGMTQPKLSLLLRGQFRGISETKMMACLM
LLGRDISIVVGEAQQARGKMRLIYEPA

Download         Length: 324 bp

>AT53211 NZ_CP011047:1426245-1426568 [Cronobacter sakazakii]
ATGACAGCAGACATTGAACGCAGTAACGGAAATGTGTATGACGATCTCGGGCTTATCGACGCCGAAGAGATGCAGCTAAA
AGCGCAGCTCGCTATGGCCGTTAGCGACATTCTTAAAGCGCGCGGCTTAACCCAGCAGGAGGCGGCCCGTCTTCTGGGCA
TGACCCAGCCAAAACTTTCTTTATTACTTCGCGGCCAGTTTCGCGGGATCAGCGAAACGAAAATGATGGCCTGCCTGATG
CTCCTCGGGCGGGATATCAGTATCGTCGTCGGCGAAGCACAACAGGCGCGCGGAAAAATGCGCCTGATTTATGAGCCAGC
CTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7V7RAE9

Antitoxin

Source ID Structure
AlphaFold DB A0A7V7RA28

References